Microbial Degradation of Chlorophenols

El‐Naas, Muftah H.; Mousa, Hussein A.; Gamal, Maisa El

doi:10.1007/978-3-319-45156-5_2

Cited by 12 publications

(13 citation statements)

References 157 publications

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“…Tt PPO and its variants were able to convert CPs at high concentrations (5 mM) that are usually toxic for microorganisms ( 34 ). The biotransformation yields for the tested CPs ranged from 21% to 35.4%, as measured by HPLC, and led to the formation of a brown precipitate.…”

Section: Discussionmentioning

confidence: 99%

“…Chlorophenols (CPs) are common organic pollutants introduced in the environment by the activities of various industries and are mainly associated with the production, use, and degradation of several pesticides. CPs may also be produced when wastewater or drinking water is disinfected with chlorine under certain conditions ( 34 ). Some CPs have been listed by the US Environmental Protection Agency as priority contaminants, as they impose many health risks for living organisms, like DNA damage, oxidative stress, toxicity, and carcinogenicity ( 35 ).…”

Section: Introductionmentioning

confidence: 99%

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Versatile Fungal Polyphenol Oxidase with Chlorophenol Bioremediation Potential: Characterization and Protein Engineering

Nikolaivits

Dimarogona

Karagiannaki

et al. 2018

Appl Environ Microbiol

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A novel fungal PPO was heterologously expressed and biochemically characterized. Construction of single and double mutants led to the generation of variants with altered specificity against CPs. Through this work, knowledge is gained regarding the effect of mutations on the substrate specificity of PPOs. This work also demonstrates that more potent biocatalysts for the bioremediation of harmful CPs can be developed by applying site-directed mutagenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Versatile Fungal Polyphenol Oxidase with Chlorophenol Bioremediation Potential: Characterization and Protein Engineering

Nikolaivits

Dimarogona

Karagiannaki

et al. 2018

Appl Environ Microbiol

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“…Chlorophenols (CPs) constitute a class of organic compounds containing at least one chlorine atom attached on a phenol moiety. CPs are introduced in the environment as metabolites of herbicides and other chlorinated xenobiotics or through anthropogenic activities as effluent discharge of industrial processes; for instance, pulp bleaching, dye manufacturing, water disinfection with chlorine, waste burning, and wood waste incineration [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…These compounds can be detected in water, soil and the atmosphere after volatilization and they can also accumulate in the adipose tissue of living organisms due to their lipophilicity [2,3]. 2,4-Dichlorophenol (2,4-DCP) has been widely used as a fungicide, pesticide, and wood preservative [4], being released in high amounts into the environment (ca.…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates

et al. 2019

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Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released in high amounts in the environment and has been listed as a priority pollutant by the US Environmental Protection Agency. Bioremediation has been proposed as a sustainable alternative to conventional remediation methods for the detoxification of phenolic compounds. In this work, we studied the potential of fungal strains isolated as symbionts of marine invertebrates from the underexplored mesophotic coral ecosystems. Hence, the unspecific metabolic pathways of these fungal strains are being explored in the present study, using the powerful analytical capabilities of a UHPLC-HRMS/MS. The newly identified 2,4-DCP metabolites add significantly to the knowledge of the transformation of such pollutants by fungi, since such reports are scarce.

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“…CHL (C 8 H 9 ClO) is a chlorinated phenolic compound that often persists in the environment under aerobic conditions. While dioxygenase is involved in catalyzing the cleavage of aromatic rings, the dioxygenase-mediated reaction may interfere with the chlorine atoms of chlorinated aromatic compounds due to steric and electronic interactions (7). Accordingly, the degradation of chlorinated phenolic compounds is largely due to bacteria capable of catalyzing the removal of chlorine atoms by dehalogenase enzymes, followed by the breakdown of aromatic compounds via dioxygenase-mediated pathways.…”

Section: Resultsmentioning

confidence: 99%

Removal of Chloroxylenol Disinfectant by an Activated Sludge Microbial Community

Choi

2019

Microb. Environ.

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Chloroxylenol (CHL) is an antimicrobial ingredient that is frequently used in antiseptics/disinfectants for skin ( e.g . hand soap) and non-living surfaces. CHL is an alternative to triclosan and triclocarban, the use of which has recently been banned in some countries. Accordingly, the more widespread use of CHL may significantly increase its occurrence and level in aquatic environments in the near future, eventually resulting in potential ecological risks. Wastewater treatment plants (WWTPs) may be a point source of CHL in natural environments due to extensive discharge through urban waste stream disposal. While the satisfactory removal of CHL in WWTPs is critical for maintaining healthy aquatic ecosystems, the extent of CHL removal and whether CHL causes system upset/failure in WWTPs currently remain unknown. In the present study, we conducted bioreactor operation and batch experiments to investigate the fate and effects of CHL and elucidate the mechanisms underlying degradation at various levels from environmentally relevant to high levels (0.5–5 mg L −1 ). Bioreactors partially removed CHL (44–87%) via a largely biological route. Microbial association networks constructed using 16S rRNA gene sequencing data revealed selective enrichment and a correlation between Sphingobium and CHL, implying its involvement in the biological breakdown of CHL through dehalogenation and ring hydroxylation pathways. The present results provide insights into the behavior and effects of CHL in activated sludge communities and important information for the sustainable management of CHL that may be an emerging issue in the urban water cycle.

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Microbial Degradation of Chlorophenols

Cited by 12 publications

References 157 publications

Versatile Fungal Polyphenol Oxidase with Chlorophenol Bioremediation Potential: Characterization and Protein Engineering

Versatile Fungal Polyphenol Oxidase with Chlorophenol Bioremediation Potential: Characterization and Protein Engineering

Unraveling the Detoxification Mechanism of 2,4-Dichlorophenol by Marine-Derived Mesophotic Symbiotic Fungi Isolated from Marine Invertebrates

Removal of Chloroxylenol Disinfectant by an Activated Sludge Microbial Community

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