Microbial-Derived Polyhydroxyalkanoate-Based Scaffolds for Bone Tissue Engineering: Biosynthesis, Properties, and Perspectives

Li, Jian; Zhang, Xu; Udduttula, Anjaneyulu; Fan, Zhi Shan; Chen, Jian Hai; Sun, Aijuan; Zhang, Peng

doi:10.3389/fbioe.2021.763031

Cited by 14 publications

(7 citation statements)

References 159 publications

(103 reference statements)

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“…[156] However, PHAs' relatively hydrophobic nature and weak mechanical characteristics have largely limited their application. [157]…”

Section: Piezoelectric Materialsmentioning

confidence: 99%

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Liu,

Zhang,

et al. 2023

Adv Funct Materials

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Physical cues like morphology, light, electric signal, mechanic signal, magnetic signal, and heat can be used as alternative regulators for expensive but short‐acting growth factors in bone tissue engineering to promote osteogenic differentiation and bone regeneration. As physical stimulation applied directly to the tissue cannot be focused on the bone defect area to regulate the cell behaviors and fate in situ, this limits the efficiency of precise bone regeneration. Biomaterials‐mediated in situ physical cues, as an effective strategy combining the synergistic effect of materials themselves, are put forward and studied widely to promote osteogenic differentiation and bone repair efficiently and precisely. Different types of physical cues provide different choices to better satisfy the requirements for targeted bone defect repair. In this review, the recent research about different biomaterials‐mediated physical cues accelerating osteogenesis in vitro and promoting in situ bone formation in vivo is introduced. Meanwhile, the corresponding possible mechanisms of various physical cues regulating cell responses are also discussed. This review provides useful and enlightening guidance for the utilization of intrinsically physical properties of functional materials to achieve efficient bone regeneration, leading to the design and construction of smart biomaterials for practical applications, and eventually promoting clinical translation.

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“…[156] However, PHAs' relatively hydrophobic nature and weak mechanical characteristics have largely limited their application. [157]…”

Section: Piezoelectric Materialsmentioning

confidence: 99%

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Liu,

Zhang,

et al. 2023

Adv Funct Materials

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“…PHAs are purified using many techniques, such as precipitation, filtration, centrifugation, or chromatography. Their performance and properties depend on the purification [35,36].…”

Section: Polyhydroxyalkanoates (Phas)mentioning

confidence: 99%

Application of Biopolymers as Sustainable Cladding Materials: A Review

Nazrun,

Hassan,

Hossain

et al. 2023

Sustainability

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The application of biopolymer materials in cladding presents a promising avenue for enhancing building sustainability, while addressing the limitations of conventional synthetic polymers. Cladding serves a dual purpose of protection and aesthetics for buildings, but increasing global energy consumption and environmental concerns necessitate the adoption of sustainable practices. The construction sector’s substantial energy usage and greenhouse gas emissions highlight the urgent need for sustainable building materials. Conventional cladding materials often lack sustainability and environmental compatibility. Biopolymers, derived from living organisms or by-products, offer a potential solution with their biodegradability, renewability, and low embodied energy. These materials can revolutionise cladding practices by providing eco-friendly alternatives aligned with sustainable construction demands. Integrating biopolymers with synthetic polymers can enhance material biodegradability, contributing to overall degradation. Prominent biopolymers like PLA, PHAs, starch-based polymers, cellulose, PHB, and PBS exhibit biodegradability and sustainability, positioning them in the front rank for cladding applications. Despite significant research in biopolymer applications in different fields, there is limited research to identify the application and limitations of biopolymers as building cladding materials. This review paper aims to bridge the research gaps by comprehensively analysing diverse biopolymer cladding materials based on their properties and exploring their cross-domain utility, thereby highlighting their transformative role in sustainable construction practices. The expanding biopolymer market in building cladding materials underscores their potential to drive innovation, with projected growth emphasising their importance.

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“…The efficiency of the production process with a low polymer concentration and high substrate cost must also be taken into account, as providing a large-scale production process is economically impracticable. Recent research in tissue engineering using PHAs has been mainly aimed at wound management [ 106 , 107 ], nerve regeneration [ 108 ], cardiac- and coronary-related tissue engineering, and bone reconstruction [ 49 , 105 , 109 , 110 ]. Due to relatively low market availability, only a few of more than 90 known PHAs are available.…”

Section: Tissue Engineeringmentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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Microbial-Derived Polyhydroxyalkanoate-Based Scaffolds for Bone Tissue Engineering: Biosynthesis, Properties, and Perspectives

Cited by 14 publications

References 159 publications

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Materials‐Mediated In Situ Physical Cues for Bone Regeneration

Application of Biopolymers as Sustainable Cladding Materials: A Review

Special Features of Polyester-Based Materials for Medical Applications

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