2024
DOI: 10.1101/2024.03.20.24304637
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Microbial determinants of dementia risk in subjects of Mexican descent with type 2 diabetes living in South Texas

Lisa M. Matz,
Nisarg S. Shah,
Laura Porterfield
et al.

Abstract: Type 2 diabetes (T2D) is a common forerunner of neurodegeneration and dementia, including Alzheimer’s Disease (AD), yet the underlying mechanisms remain unresolved. Individuals of Mexican descent living in South Texas have increased prevalence of comorbid T2D and early onset AD, despite low incidence of the predisposing APOE-e4 variant and an absence of the phenotype among relatives residing in Mexico – suggesting a role for environmental factors in coincident T2D and AD susceptibility. Here, in a small clinic… Show more

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