Microbial exopolysaccharides: Synthesis pathways, types and their commercial applications

Rana, Sonali; Upadhyay, Lata Sheo Bachan

doi:10.1016/j.ijbiomac.2020.04.084

Cited by 122 publications

(54 citation statements)

References 45 publications

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“…Wound healing and tissue-engineered blood vessels [10] Ochrobactrum pseudintermedium Surfactant for antibacterial properties [14] Dextran Leuconostoc spp. Nanogels for intracellular drug delivery [15] Drug encapsulating agent [16] Leuconostoc mesenteroides strain 7E…”

Section: Gluconacetobacter Xylinummentioning

confidence: 99%

“…Nanoparticles for the treatment of diabetes in rats in vivo [24] Anticancer drug delivery to SCC7 carcinoma cell line, human breast adenocarcinoma (MCF-7) cell line, and human lung epithelial adenocarcinoma (A549) [16] Streptococcus sp. Ophthalmic surgery, wound healing [10] Streptococcus equi, Streptococcus zooepidemicus…”

Section: Bifidobacteriummentioning

confidence: 99%

“…Administration of nasal formulations [4] Sphingomonas paucimobilis Tissue engineering and bone regeneration [25] n.a. Injectable gellan-based hydrogel to treat a bone defect [38,39] Nano-hydrogel for drug delivery [19] Composite scaffold for skin regeneration [27] Lactic acid bacteria Microencapsulation matrix for drug delivery [12] Levan Halomonas smyrnensis Levan-based scaffold for tissue engineering [40] Multilayer film for the enhancement of live cell adhesive properties, harbor aldehyde groups for antitumor properties [41] Disintegration agent in immediate-release tablets [16] Sulfated levan for cardiac tissue engineering [42] Bacillus subtilis, Streptococcus mutans, Streptococcus salivarius…”

Section: Paenibacillus Polymyxamentioning

confidence: 99%

“…Biosynthesis of EPSs in bacteria occurs in intra-and extracellular ways. There are four general mechanisms for EPS biosynthesis in bacterial cells, which are the Wzx/Wzydependent pathway, the ABC transporter-dependent pathway, the synthase-dependent pathway, and extracellular biosynthesis by sucrase protein [9,16,[49][50][51]. The aforementioned microbial pathways are shown in Figure 3.…”

Section: Microbial Biosynthesis Of Exopolysaccharidesmentioning

confidence: 99%

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Biomedical Applications of Bacterial Exopolysaccharides: A Review

et al. 2021

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Bacterial exopolysaccharides (EPSs) are an essential group of compounds secreted by bacteria. These versatile EPSs are utilized individually or in combination with different materials for a broad range of biomedical field functions. The various applications can be explained by the vast number of derivatives with useful properties that can be controlled. This review offers insight on the current research trend of nine commonly used EPSs, their biosynthesis pathways, their characteristics, and the biomedical applications of these relevant bioproducts.

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Section: Gluconacetobacter Xylinummentioning

confidence: 99%

Section: Bifidobacteriummentioning

confidence: 99%

Section: Paenibacillus Polymyxamentioning

confidence: 99%

Section: Microbial Biosynthesis Of Exopolysaccharidesmentioning

confidence: 99%

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Biomedical Applications of Bacterial Exopolysaccharides: A Review

et al. 2021

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“…Then, the ions are engulfed in the fungal cytoplasm where they are assimilated and sequestrated by the cellular reactions [53]. In addition, the fungi can release exopolysaccharides (high-molecular-weight polymers composed of sugar residues) to entrap or adsorb the extracellular Cd 2+ ions [54].…”

Section: Proposed Mechanism For CD 2+ Removalmentioning

confidence: 99%

In Vitro Bioadsorption of Cd2+ Ions: Adsorption Isotherms, Mechanism, and an Insight to Mycoremediation

et al. 2020

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The objective of this paper is to establish the significance of the mycoremediation of contaminants such as Cd2+ to achieve sustainable and eco-friendly remediation methods. Industries such as electroplating, paint, leather tanning, etc. release an enormous amount of Cd2+ in wastewater, which can drastically affect our flora and fauna. Herein, we report on the in vitro bioadsorption of Cd2+ ions using fungal isolates obtained from different contaminated industrial sites. The detailed studies revealed that two fungal species, i.e., Trichoderma fasciculatum and Trichoderma longibrachiatum, were found to be most effective against the removal of Cd2+ when screened for Cd2+ tolerance on potato dextrose agar (PDA) in different concentrations. Detailed adsorption studies were conducted by exploring various experimental factors such as incubation time, temperature, pH, inoculum size, and Cd2+ salt concentrations. Based on optimum experimental conditions, T. fasciculatum exhibited approximately 67.10% removal, while T. longibrachiatum shows 76.25% removal of Cd2+ ions at pH 5.0, 120 h incubation time, at 30°C. The inoculum sizes for T. fasciculatum and T. longibrachiatum were 2.5% and 2.0%, respectively. Finally, the morphological changes due to Cd2+ accumulation were examined using scanning electron microscopy (SEM). Further, Fourier transform infrared spectroscopy (FTIR) spectroscopy reveals the presence of various functional groups (-CH, –C=O, NH and –OH), which seem to be responsible for the efficient binding of Cd2+ ions over the fungal surfaces.

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Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation

Vinothkanna,

Shi‐Liang,

Karthick Rajan

et al. 2024

Food Frontiers

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People with diabetes mellitus (DM) and hyperglycemia are linked with cancer risk. Diabetes and cancer have been corroborated by high morbidity and mortality rates. Studies revealed that elevated levels of insulin secretions trigger insulin‐like growth factor 1 (IGF‐1) production. Moreover, IGF‐1 is a key regulator involved in promoting cancer cell progression and is linked with DM. Cancer drug resistance and ototoxic effects can adversely affect the health and lifespan of an individual. However, naturally derived bioactive compounds are gaining attention for their nontoxic properties and specific behavior. Likewise, probiotics have also been regarded as safe and successful alternatives to treat DM‐linked cancers. The present review aims to highlight the therapeutic potential and feasible functions of probiotics to mitigate or inhibit DM‐associated cancers. Meanwhile, the intracellular signaling cascades involved in promoting DM‐linked cancer are enumerated for future prospective research. However, metabolomics interactions and protein–protein interactions are to be discussed for deeper insights into affirmative principles in diabetic‐linked cancers. Drug discovery and innovative preclinical evaluation need further adjuvant and immune‐enhancement therapies. Furthermore, the results of the in silico assessment could provide scientific excellence of IGF‐1 in diabetes and cancer. Overall, this review summarizes the mechanistic insights and therapeutic targets for diabetes‐associated cancer.

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Microbial exopolysaccharides: Synthesis pathways, types and their commercial applications

Cited by 122 publications

References 45 publications

Biomedical Applications of Bacterial Exopolysaccharides: A Review

Biomedical Applications of Bacterial Exopolysaccharides: A Review

In Vitro Bioadsorption of Cd2+ Ions: Adsorption Isotherms, Mechanism, and an Insight to Mycoremediation

Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation

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