Microbial extracellular vesicles contribute to antimicrobial resistance

Jiang, Bowei; Lai, Yi; Xiao, Wenhao; Zhong, Tianyu; Liu, Fengping; Gong, Junjie; Huang, Junyun

doi:10.1371/journal.ppat.1012143

Cited by 4 publications

(2 citation statements)

References 101 publications

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“…Nonetheless, the disruption of cytoplasmic membrane integrity still results in bacterial cell death. Therefore, this mechanism is termed “bubbling cell death” ( Jiang et al., 2024 ).…”

Section: Types and Biogenesis Of Bacterial Evsmentioning

confidence: 99%

Influences of bacterial extracellular vesicles on macrophage immune functions

Jiang,

Huang

2024

Front. Cell. Infect. Microbiol.

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Bacterial extracellular vesicles (EVs) are crucial mediators of information transfer between bacteria and host cells. Macrophages, as key effector cells in the innate immune system, have garnered widespread attention for their interactions with bacterial EVs. Increasing evidence indicates that bacterial EVs can be internalized by macrophages through multiple pathways, thereby influencing their immune functions. These functions include inflammatory responses, antimicrobial activity, antigen presentation, and programmed cell death. Therefore, this review summarizes current research on the interactions between bacterial EVs and macrophages. This will aid in the deeper understanding of immune modulation mediated by pathogenic microorganisms and provide a basis for developing novel antibacterial therapeutic strategies.

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“…Nonetheless, the disruption of cytoplasmic membrane integrity still results in bacterial cell death. Therefore, this mechanism is termed “bubbling cell death” ( Jiang et al., 2024 ).…”

Section: Types and Biogenesis Of Bacterial Evsmentioning

confidence: 99%

Influences of bacterial extracellular vesicles on macrophage immune functions

Jiang,

Huang

2024

Front. Cell. Infect. Microbiol.

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“…OMVs can also serve as a biofilm nucleation factor, they maintain cohesion inside biofilms [8,27] and provide communication between bacterial cells [28]. In addition to these functions, it is worth noting that OMVs can protect bacteria against antimicrobial substances through three main mechanisms: 1) encapsulation of antibiotics and their removal from the cell; 2) direct binding of antibiotics to the surface of OMVs; and 3) destruction of antibiotic molecules entering the OMV due to the action of periplasmic enzymes [29]. In particular, OMVs produced by Acholeplasma laidlawii have been shown to contain fluoroquinolone antibiotics such as ciprofloxacin [30], and OMVs produced by Pseudomonas aeruginosa contain aminoglycosides such as gentamicin [31], indicating that OMVs can remove antibiotics from the cell.…”

Section: Introductionmentioning

confidence: 99%

Cationic Biocides Tend to Embed into the Inner Layer of the Model Outer Membrane Vesicles of Gram-negative Bacteria: Computational Insights

Kholina,

Kovalenko,

Strakhovskaya

2024

Math.Biol.Bioinf.

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The outer membrane vesicles (OMVs), produced by many pathogenic bacteria, play a significant role in bacterial pathogenesis. They promote bacterial resistance to antibiotics and act as natural protective barriers. The study of OMVs is essential both for understanding the general mechanisms of bacterial pathogenicity and for the development of the antibacterial drugs. In this paper, we created model vesicle that imitate the OMVs of Gram-negative bacteria using molecular modeling techniques. To investigate the interaction of the cationic antimicrobial compounds with the outer lipopolysaccharide (LPS) monolayer and the inner phospholipid monolayer of the OMV membrane, we performed molecular dynamics simulations by placing molecules of the cationic antiseptic octenidine on the outside or inside of model vesicles. The interaction of octenidine with the outer and inner monolayer was significantly different: octenidine interacted weakly with the outer LPS surface of the model OMV, but exhibited high affinity for the phospholipids of the inner monolayer. To study the translocation of cationic antimicrobial molecules within model OMV, we performed steered molecular dynamics simulations. For all three cationic biocide molecules, antiseptic octenidine, photosensitizer octakis(cholinyl)zinc phthalocyanine, and dye methylene blue, it turned out that, along with the LPS of the outer membrane of the OMV, the phosphates of lipid A molecules represent the final barrier to their penetration into the model OMV.

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The underlying mechanisms of oxytetracycline degradation mediated by gut microbial proteins and metabolites in Hermetia illucens

Cao,

Liu,

et al. 2024

Science of The Total Environment

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Microbial extracellular vesicles contribute to antimicrobial resistance

Cited by 4 publications

References 101 publications

Influences of bacterial extracellular vesicles on macrophage immune functions

Influences of bacterial extracellular vesicles on macrophage immune functions

Cationic Biocides Tend to Embed into the Inner Layer of the Model Outer Membrane Vesicles of Gram-negative Bacteria: Computational Insights

The underlying mechanisms of oxytetracycline degradation mediated by gut microbial proteins and metabolites in Hermetia illucens

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