Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

Patridge, Eric; Gorakshakar, Anmol; Molusky, Matthew M.; Ogundijo, Oyetunji; Janevski, Angel; Julian, Cristina; Hu, Lan; Vuyisich, Momchilo; Banavar, Guruduth

doi:10.1016/j.csbj.2024.01.018

Computational and Structural Biotechnology Journal

2024

DOI: 10.1016/j.csbj.2024.01.018

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Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

Eric Patridge,

Anmol Gorakshakar,

Matthew M. Molusky

et al.

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Altered gut microbial functional pathways in people with Irritable Bowel Syndrome enable precision health insights

Patridge,

Gorakshakar,

Molusky

et al. 2024

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We describe a data-driven computational approach for quantifying the microbial functional pathways in the gastrointestinal tract, based on an analysis of stool metatranscriptomic data within a large and diverse adult human population (n = 66,545). We develop a suite of eight gut microbial pathway scores, each of which represents the activity of a well-defined set of microbial functional features relevant to known gut biochemical activities. We use a normative approach within a subpopulation (n = 9,350) to determine the optimal and non-optimal levels of activity of these functional pathway scores. We hypothesize that non-optimal scores are associated with irritable bowel syndrome (IBS) and its subtypes (i.e., IBS-Constipation, IBS-Diarrhea, IBS-Mixed Type). We show that non-optimal scores within these microbial functional pathways are associated with higher odds of IBS or its subtypes within an independent cohort (n = 57,195). Given these findings, these gut pathway scores can be used to deliver meaningful health insights from simple, non-invasive stool samples, as potential molecular endpoints to measure the efficacy of practical interventions, and develop data-driven personalized algorithms aimed at providing nutritional recommendations, diagnostics, and treatments for IBS as well as related conditions.

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Altered gut microbial functional pathways in people with Irritable Bowel Syndrome enable precision health insights

Patridge,

Gorakshakar,

Molusky

et al. 2024

Preprint

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Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness

Cited by 1 publication

References 113 publications

Altered gut microbial functional pathways in people with Irritable Bowel Syndrome enable precision health insights

Altered gut microbial functional pathways in people with Irritable Bowel Syndrome enable precision health insights

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