Microbial hydroxylation of 17β-estradiol by <i>Penicillium brevicompactum</i>

Shan, Lihong; Li, Yang; Chen, Yanjie; Yin, Minghui; Huang, Jiajia; Zhang, Zhenzhong; Xiufang, Shi; Liu, Hong‐Min

doi:10.1080/10242422.2016.1247816

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…The other study shows the optimization and scale-up of the degradation process regulated by Penicillium oxalicum in a batch reactor and compared the degradation between free and immobilized biomass [197]. Some species of Penicillium can be used effectively in TCS, NP and hormones degradation [198][199][200][201][202]. The yeast Yarrowia lipolytica has been studied for the expression of cytochrome P450 and it seems capable of degrading diclofenac and NPX [191,203].…”

Section: Mycoremediationmentioning

confidence: 99%

From Laboratory Tests to the Ecoremedial System: The Importance of Microorganisms in the Recovery of PPCPs-Disturbed Ecosystems

et al. 2020

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The presence of a wide variety of emerging pollutants in natural water resources is an important global water quality challenge. Pharmaceuticals and personal care products (PPCPs) are known as emerging contaminants, widely used by modern society. This objective ensures availability and sustainable management of water and sanitation for all, according to the 2030 Agenda. Wastewater treatment plants (WWTP) do not always mitigate the presence of these emerging contaminants in effluents discharged into the environment, although the removal efficiency of WWTP varies based on the techniques used. This main subject is framed within a broader environmental paradigm, such as the transition to a circular economy. The research and innovation within the WWTP will play a key role in improving the water resource management and its surrounding industrial and natural ecosystems. Even though bioremediation is a green technology, its integration into the bio-economy strategy, which improves the quality of the environment, is surprisingly rare if we compare to other corrective techniques (physical and chemical). This work carries out a bibliographic review, since the beginning of the 21st century, on the biological remediation of some PPCPs, focusing on organisms (or their by-products) used at the scale of laboratory or scale-up. PPCPs have been selected on the basics of their occurrence in water resources. The data reveal that, despite the advantages that are associated with bioremediation, it is not the first option in the case of the recovery of systems contaminated with PPCPs. The results also show that fungi and bacteria are the most frequently studied microorganisms, with the latter being more easily implanted in complex biotechnological systems (78% of bacterial manuscripts vs. 40% fungi). A total of 52 works has been published while using microalgae and only in 7% of them, these organisms were used on a large scale. Special emphasis is made on the advantages that are provided by biotechnological systems in series, as well as on the need for eco-toxicological control that is associated with any process of recovery of contaminated systems.

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Section: Mycoremediationmentioning

confidence: 99%

From Laboratory Tests to the Ecoremedial System: The Importance of Microorganisms in the Recovery of PPCPs-Disturbed Ecosystems

et al. 2020

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“…Reduction of estrone to estradiol is also known as a result of using the whole cells of yeasts ( Saccharomyces cerevisiae , Saccharomyces carlsbergensis , Pichia fermentans , Rhodotorula glutinis ) 9,10 or filamentous fungi ( Penicillium citrinum ) 10 . In filamentous fungal cultures, hydroxylation products at positions 6α, 6β, 15α are also described 11,12 , as well as simultaneous hydroxylation of estrone and carbonyl moiety reduction 11 or hydroxylation with the oxidation of estradiol’s 17β-hydroxy group 12 . Many human CYP isoforms are involved in the oxidative metabolism of 17-estradiol and estrone.…”

Section: Introductionmentioning

confidence: 99%

Cascade biotransformation of estrogens by Isaria fumosorosea KCh J2

Kozłowska

Dymarska

Kostrzewa-Susłow

et al. 2019

Sci Rep

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Estrone, estradiol, ethynylestradiol and estrone 3-methyl ether underwent a biotransformation process in the submerged culture of Isaria fumosorosea KCh J2. Estrone was transformed into seven metabolites, four of which were glycosylated. Estradiol was selectively glycosylated at C-3 and then transformed to D-ring lactone. Ethynylestradiol was coupled with methylglucoside and 6β-hydroxyderivative was obtained. Estrone 3-methyl ether was not transformed indicating that a free hydroxyl group at C-3 is necessary for glycosylation. Baeyer–Villiger oxidation combined with hydroxylation and glycosylation was observed. All glycosides obtained in this study are 3- O -β-methylglucosides.

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