Microbial Iron Acquisition: Marine and Terrestrial Siderophores

Sandy, Moriah; Butler, Alison

doi:10.1021/cr9002787

Cited by 427 publications

(401 citation statements)

References 161 publications

(394 reference statements)

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“…Siderophores are low molecular weight chelating agents produced by microbes in low iron environments to facilitate iron uptake [1]. In addition to Fe(III), siderophores have been shown to chelate other hard metal ions, such as Al(III) [2], Ga(III) [2], Mo(VI) [3], Ti(IV) [4], and V(V) [3,5,6], among others.…”

Section: Introductionmentioning

confidence: 99%

Magnetic susceptibility of Mn(III) complexes of hydroxamate siderophores

Springer

Butler

2015

Journal of Inorganic Biochemistry

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ABSTRACT:The hydroxamate siderophores putrebactin, desferrioxamine B, and desferrioxamine E bind Mn(II) and promote the air oxidation of Mn(II) to Mn(III) at pH >7.1.The magnetic susceptibility of the manganese complexes were determined by the Evans method and the stoichiometry was probed with electrospray ionization mass spectrometry (ESIMS). The room temperature magnetic moments (µ eff ) for the manganese complexes of desferrioxamines B and E were 4.85 BM and 4.84 BM, respectively, consistent with a high spin,

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Section: Introductionmentioning

confidence: 99%

Magnetic susceptibility of Mn(III) complexes of hydroxamate siderophores

Springer

Butler

2015

Journal of Inorganic Biochemistry

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“…These systems were among the first to be studied as public goods in in vitro experiments (8,9). They have also been widely studied for their role in pathogenicity (7,10) and in natural environments such as the ocean, where they may play an important role in iron acquisition under limiting conditions (11)(12)(13). Because of the dilute nature of the aquatic environment, it has been suggested that production of public goods such as siderophores is an efficient strategy only in environments where local cell densities are high (14).…”

mentioning

confidence: 99%

Public good dynamics drive evolution of iron acquisition strategies in natural bacterioplankton populations

Cordero¹,

Ventouras

DeLong

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

308

326

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A common strategy among microbes living in iron-limited environments is the secretion of siderophores, which can bind poorly soluble iron and make it available to cells via active transport mechanisms. Such siderophore-iron complexes can be thought of as public goods that can be exploited by local communities and drive diversification, for example by the evolution of "cheating." However, it is unclear whether bacterial populations in the environment form stable enough communities such that social interactions significantly impact evolutionary dynamics. Here we show that public good games drive the evolution of iron acquisition strategies in wild populations of marine bacteria. We found that within nonclonal but ecologically cohesive genotypic clusters of closely related Vibrionaceae, only an intermediate percentage of genotypes are able to produce siderophores. Nonproducers within these clusters exhibited selective loss of siderophore biosynthetic pathways, whereas siderophore transport mechanisms were retained, suggesting that these nonproducers can act as cheaters that benefit from siderophore producers in their local environment. In support of this hypothesis, these nonproducers in ironlimited media suffer a significant decrease in growth, which can be alleviated by siderophores, presumably owing to the retention of transport mechanisms. Moreover, using ecological data of resource partitioning, we found that cheating coevolves with the ecological specialization toward association with larger particles in the water column, suggesting that these can harbor stable enough communities for dependencies among organisms to evolve. microbial diversity | ocean bacteria | population structure |

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“…When low intracellular iron concentration occurs, a conformational change in the Fur protein causes its detachment from the siderophore gene promoter, reestablishing the transcription of the gene and the eventual synthesis of siderophores. Transport of iron-bound siderophores is mediated by membrane receptors, periplasmic membrane proteins and TonB-like transporters (9) and after internalization, ferric iron is reduced to its ferrous form. Additional iron acquisition systems include hemophores (10,11) and heme (12,13).…”

Section: Introductionmentioning

confidence: 99%

Biotechnology of siderophores in high-impact scientific fields

Serrano

2017

Biomolecular Concepts

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Different aspects of bacterial and fungal siderophore biotechnological applications will be discussed. Areas of application presented include, but are not limited to agriculture, medicine, pharmacology, bioremediation, biodegradation and food industry. In agriculture-related applications, siderophores could be employed to enhance plant growth due to their uptake by rhizobia. Siderophores hindered the presence of plant pathogens in biocontrol strategies. Bioremediation studies on siderophores discuss mostly the mobilization of heavy metals and radionuclides; the emulsifying effects of siderophoreproducing microorganisms in oil-contaminated environments are also presented. The different applications found in literature based in medicine and pharmacological approaches range from iron overload to drug delivery systems and, more recently, vaccines. Additional research should be done in siderophore production and their metabolic relevance to have a deeper understanding for future biotechnological advances.

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Microbial Iron Acquisition: Marine and Terrestrial Siderophores

Cited by 427 publications

References 161 publications

Magnetic susceptibility of Mn(III) complexes of hydroxamate siderophores

Magnetic susceptibility of Mn(III) complexes of hydroxamate siderophores

Public good dynamics drive evolution of iron acquisition strategies in natural bacterioplankton populations

Biotechnology of siderophores in high-impact scientific fields

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