Microbial Load of Some Medicinal Plants Sold in Some Local Markets in Abeokuta, Nigeria

Idu, MacDonald; Omonigho, Solomon Esharegoma; Erhabor, Joseph O.; Efijuemue, Harriet M

doi:10.4314/tjpr.v9i3.56285

Cited by 8 publications

(3 citation statements)

References 8 publications

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“…The roots have been documented for its use in Kenya as a treatment for joint and back ache [18]. Acacia ataxacantha pods and seeds have also been documented to be used as a stomachic herbal drug and for dysentery in Abeokuta, southwestern Nigeria [19]. Some Senegalese herbal practitioners claim that the leaves are used in the treatment of gastric ulcer.…”

Section: Introductionmentioning

confidence: 99%

Ulcero-protective Potentials of Methanolic Extract of Acacia ataxacantha Leaves in Indomethacin and Stress Induced Gastric Ulcer Models

Akapa

2014

IJBCRR

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Section: Introductionmentioning

confidence: 99%

Ulcero-protective Potentials of Methanolic Extract of Acacia ataxacantha Leaves in Indomethacin and Stress Induced Gastric Ulcer Models

Akapa

2014

IJBCRR

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“…This species is widespread in much of sub-Saharan Africa. This species has been reported in Benin, Nigeria and Kenya for the treatment of tooth decay, dysentery, bronchitis, cough and joint pain [17–19]. Antimicrobial and antioxidant activities of the extracts of A. ataxacantha have also been reported previously [20, 21].…”

Section: Introductionmentioning

confidence: 63%

Acthaside: a new chromone derivative from Acacia ataxacantha and its biological activities

Amoussa¹,

Bourjot²,

Lagnika³

et al. 2016

BMC Complement Altern Med

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Background Acacia ataxacantha (Fabaceae), used in traditional medicine grows in the South-West of Bénin. Ethyl acetate extract of the barks of this species was previously reported to display various bioactivities, including antibacterial, antifungal and antioxidant activities. In the present study, we investigate the antimicrobial and antioxidant activities of compound isolated from ethyl acetate extract of Acacia ataxacantha.MethodsPurification, isolation and structural identification of isolated compound were done using various chromatographic and spectroscopic methods. Antimicrobial activity was investigated using a two-fold serial microdilution method. The inhibitory potency of isolated compound was evaluated by kinetic experiments. The antioxidant activity was also determined using 2, 2-diphenyl-1-picrylhydrazyl.ResultsThe isolated compound was identified as 7-hydroxy-2-methyl-6-[β-galactopyranosyl-propyl]-4H-chromen-4-one. As far as we know, this compound, named “acthaside”, reported for the first time, was active against all tested microorganisms with minimal inhibitory concentration ranging from 25 to 50 μg/ml. At 50 μl/ml, no growth was observed in almost all tested microbial after 24 h of exposure. The isolated compound had significant antioxidant activity with an IC50 value of 3.61 ± 0.12 μg/ml compared to quercetin (IC50 1.04 ± 0.01 μg/ml).ConclusionThe present work demonstrates that the new chromen derivative isolated from A. ataxacantha may help treat bacterial and yeast infections. However, further studies are required to clarify the mechanism of action of this compound.Electronic supplementary materialThe online version of this article (doi:10.1186/s12906-016-1489-y) contains supplementary material, which is available to authorized users.

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“…Most of these herbal preparations are used in different forms and may carry a large number of microorganisms originating from the soil, usually adhering to leaves, stems, flowers, seeds and root of herbs (Adeleye, Okogi & Ojo 2005). The occurrence of pathogenic bacteria and fungi in plant samples has been reviewed and reported by Kneifel, Zech and Kopp (2002) and Idu, Erahbor and Idele (2011), respectively.…”

Section: Introductionmentioning

confidence: 99%

User frequency and microbial contaminants of traditional oral powdered herbal formulations in Ogbomoso, Nigeria

Ideh

Ogunkunle

2019

JOMPED

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Background: Being natural, herbal products are often perceived as safe but studies have shown that they may not be free of pathogenic microorganisms. The extent of microbial contaminants of traditional oral powdered herbal formulations (TOPHFs) in Ogbomoso, Nigeria, is not known, while the frequency of users of these drugs in the study area has not been reported.Aim: To evaluate the microbial contaminants of TOPHFs marketed in Ogbomoso Nigeria, identify the risk factors associated with their production and handling, and determine the frequency of users of the drugs.Setting: Ogbomoso, Nigeria.Methods: Fifteen manufacturers of TOPHFs listed the health conditions that are indicated for their drugs, while 125 residents provided information on their preference for those drugs. The questionnaires were analysed using descriptive statistics (frequency counts and percentages). Packaging and/or handling and level of personal and environmental hygiene of the manufacturers were examined and analysed for significance of their influence on contamination of drugs using chi-square test. Using pour plate method and following standard procedures, 12 samples of TOPHFs were analysed to quantify their bacterial and fungal contaminants.Results: The TOPHFs were indicated for 17 different types of health conditions with 60% of the sampled population being prolonged and regular users. The personal and environmental hygiene levels of the manufacturers fell short of acceptable standard. Ten out of the 12 samples analysed were heavily contaminated (i.e. above WHO limits) with yeasts/moulds and faecal coliforms such as Enterobacteria, 9 with Streptococcus and 6 with pathogenic bacterial species such as Staphylococcus and Salmonella. There was a significant association of TOPHFs contamination with manufacturers’ level of formal education (p = 0.001), solid waste management (p = 0.015) and methods of updating knowledge and expertise (p = 0.004), thus making these 3 the risk factors associated with contamination of the drugs.Conclusion: Use of TOPHFs is popular among the residents of Ogbomoso, but there is a high rate of contamination of these drugs with some potentially pathogenic organisms because of insufficient quality control in their production and handling.

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Microbial Load of Some Medicinal Plants Sold in Some Local Markets in Abeokuta, Nigeria

Cited by 8 publications

References 8 publications

Ulcero-protective Potentials of Methanolic Extract of Acacia ataxacantha Leaves in Indomethacin and Stress Induced Gastric Ulcer Models

Ulcero-protective Potentials of Methanolic Extract of Acacia ataxacantha Leaves in Indomethacin and Stress Induced Gastric Ulcer Models

Acthaside: a new chromone derivative from Acacia ataxacantha and its biological activities

User frequency and microbial contaminants of traditional oral powdered herbal formulations in Ogbomoso, Nigeria

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