Microbial metabolism of cannflavin A and B isolated from Cannabis sativa

Ibrahim, Amany K.; Radwan, Mohamed M.; Ahmed, Safwat A.; Slade, Desmond; Ross, Samir A.; ElSohly, Mahmoud A.; Khan, Ikhlas A.

doi:10.1016/j.phytochem.2010.02.011

Cited by 38 publications

(21 citation statements)

References 29 publications

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“…It has been reported to have antiviral properties, anti-inflammatory effects, cardioprotective, anticancer activities, antioxidant and antimicrobial effects. This compound can be used in the future for the effective drug designing against HIV-1 Protease [25]. Emodin has been previously reported to have antifungal and anti-bacterial properties.…”

Section: Discussionmentioning

confidence: 99%

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

2019

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The HIV-1 protease plays an essential role in the replication cycle of HIV-1; therefore there is a direct need to develop novel inhibitors of the HIV-1 protease, which can cease the viral replication. The present study targets the discovery of potential inhibitors of HIV-1 protease from a set of phytochemicals. From 2505 phytochemicals, 108 compounds were docked, after screening, with the HIV-1 protease to analyze their inhibitory potential against the protease. DFT analysis was also conducted to study the reactivity of strongly docked compounds. Out of 108 phytochemicals, 38 compounds showed binding affinity greater than the desired threshold. Reactivity of these 38 inhibitors was also high as compared to other compounds, based on the DFT results. These results suggest that the selected 38 phytochemicals are drug candidates and they have the potential to be effectively used against HIV in the future.

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Section: Discussionmentioning

confidence: 99%

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

2019

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“…In this review, we aim at following the long journey of phytocannabinoids from their biosynthesis in the plants towards the receptors in humans where they exert their potential effects. caryophyllene, di-and triterpenes, as well as various common compounds [30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Cannabis: A Treasure Trove or Pandora's Box?

Solymosi

Köfalvi

2017

MRMC

122

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We summarize our current knowledge on the recreational use of cannabis with respect to the modes of consumption, short-term effects, chronic health consequences and cannabis use disorder. Next, we overview the molecular targets of a dozen major and minor bioactive cannabinoids in the body. This helps us introduce the endocannabinoid system in an unprecedented detail: its up-todate molecular biology, pharmacology, physiology and medical significance, and beyond. In conclusion, we offer an unbiased survey about cannabis to help better weigh its medical value versus the associated risks.

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“…They include sulfation by Cunninghamella elegans (Cerniglia et al, 1982;Ibrahim, 2000), by Streptomyces fulvissimus (Ibrahim and Abul-Hajj, 1989), by Mucor ramannianus and by Beauveria bassiana (Ibrahim et al, 2010).…”

Section: Resultsmentioning

confidence: 99%