Microbial metabolism of fluorinated drugs

Murphy, Cormac D.; Palmer-Brown, William; Quinn, Laura; Saccomanno, Marta

doi:10.1016/b978-0-12-812733-9.00007-6

Cited by 2 publications

(4 citation statements)

References 76 publications

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“…Many oxidative enzymes are known to oxidize fluorinated derivatives of natural substances. In contrast to CTP5-FU was not readily biodegradable by T. versicolor and inoculum from the effluent of STP [78]. In fact, some fluorinated drugs require advanced photo-oxidation treatment for degradation [81].…”

Section: Fungal and Bacterial Biodegradation Of Anpsmentioning

confidence: 94%

“…CTP, a fluorinated drug was degraded entirely after 14 days at a concentration of 1 mg/L using three white-rot fungi: Bjerkandera sp. R1, Bjerkandera adjusta, and Phanerochaete chrysosporium [78]. Biotransformation of many fluorinated compounds such as fluorophenol, fluorobenzene, and fluorobenzoic acid by aerobic microorganisms is reported [79,80].…”

Section: Fungal and Bacterial Biodegradation Of Anpsmentioning

confidence: 99%

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Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions

et al. 2020

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The global burden of cancer is on the rise, and as a result, the number of therapeutics administered for chemotherapy is increasing. The occupational exposure, recalcitrant nature and ecotoxicological toxicity of these therapeutics, referred to as antineoplastic (ANP) drugs, have raised concerns about their safe remediation. This review provides an overview of the environmental source of ANPs agents, with emphasis on the currently used remediation approaches. Outpatient excreta, hospital effluents, and waste from pharmaceutical industries are the primary source of ANP waste. The current review describes various biotic and abiotic methods used in the remediation of ANP drugs in the environment. Abiotic methods often generate transformation products (TPs) of unknown toxicity. In this light, obtaining data on the environmental toxicity of ANPs and its TPs is crucial to determine their toxic effect on the ecosystem. We also discuss the biodegradation of ANP drugs using monoculture of fungal and bacterial species, and microbial consortia in sewage treatment plants. The current review effort further explores a safe and sustainable approach for ANP waste treatment to replace existing chemical and oxidation intensive treatment approaches. To conclude, we assess the possibility of integrating biotic and abiotic methods of ANP drug degradation.

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Section: Fungal and Bacterial Biodegradation Of Anpsmentioning

confidence: 94%

Section: Fungal and Bacterial Biodegradation Of Anpsmentioning

confidence: 99%

Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions

et al. 2020

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“…This is possibly due to the scarce information in the literature about the involvement of the fluorine atom in biodegradation processes. Very few studies about the biotransformation of model organofluorine compounds discerning the mechanisms of their biochemical degradation or showing that the position of the fluorine substitution in the molecule has an important role in the C–F bond cleavage have been reported, , which is often necessary for the biodegradation of fluorinated drugs …”

Section: Fluorine-containing Pharmaceuticals Withdrawn From the Marketmentioning

confidence: 99%

“…Very few studies about the biotransformation of model organofluorine compounds discerning the mechanisms of their biochemical degradation or showing that the position of the fluorine substitution in the molecule has an important role in the C−F bond cleavage have been reported, 269,270 which is often necessary for the biodegradation of fluorinated drugs. 271 In some cases, defluorination can take place spontaneously or during drug biotransformation, depending on the electrophilicity of the molecule toward direct reaction with nucleophilic groups present in amino acids or proteins. Despite the strength of the C−F bond, defluorination can occur during drug metabolism, favoring the formation of smaller fluorinated metabolites and/or the stable fluoride ion, which is a good leaving group.…”

Section: Fluorine-containing Pharmaceuticals Withdrawn From the Marketmentioning

confidence: 99%

Chemical Aspects of Human and Environmental Overload with Fluorine

et al. 2021

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Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing compounds in modern technology and daily life, the explosive development of the fluorochemical industry led to an enormous increase of emission of fluoride ions into the biosphere. This made it more and more important to understand the biological activities, metabolism, degradation, and possible environmental hazards of such substances. This comprehensive and critical review focuses on the effects of fluoride ions and organofluorine compounds (mainly pharmaceuticals and agrochemicals) on human health and the environment. To give a better overview, various connected topics are also discussed: reasons and trends of the advance of fluorine-containing pharmaceuticals and agrochemicals, metabolism of fluorinated drugs, withdrawn fluorinated drugs, natural sources of organic and inorganic fluorine compounds in the environment (including the biosphere), sources of fluoride intake, and finally biomarkers of fluoride exposure.

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Microbial metabolism of fluorinated drugs

Cited by 2 publications

References 76 publications

Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions

Environmental Remediation of Antineoplastic Drugs: Present Status, Challenges, and Future Directions

Chemical Aspects of Human and Environmental Overload with Fluorine

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