Microbial Natural Products

Sánchez, Sergio; Guzmán‐Trampe, Silvia; Ávalos, Mariana; Ruiz, Beatriz; Rodríguez‐Sanoja, Romina; Manuel, José

doi:10.1002/9781118391815.ch3

Cited by 15 publications

(11 citation statements)

References 83 publications

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“…The chemicals produced by life on Earth are numbering in the hundreds of thousands [estimated from plant natural products (Gunatilaka, 2012), microbial natural products (Sanchez et al, 2012), and marine natural products (Fusetani, 2012)]. But only a subset of hundreds of these are volatile enough to enter Earth's atmosphere at more than trace concentrations.…”

Section: Gases Produced By Life (On Earth)mentioning

confidence: 99%

Toward a List of Molecules as Potential Biosignature Gases for the Search for Life on Exoplanets and Applications to Terrestrial Biochemistry

2016

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Thousands of exoplanets are known to orbit nearby stars. Plans for the next generation of space-based and ground-based telescopes are fueling the anticipation that a precious few habitable planets can be identified in the coming decade. Even more highly anticipated is the chance to find signs of life on these habitable planets by way of biosignature gases. But which gases should we search for? Although a few biosignature gases are prominent in Earth's atmospheric spectrum (O 2 , CH 4 , N 2 O), others have been considered as being produced at or able to accumulate to higher levels on exo-Earths (e.g., dimethyl sulfide and CH 3 Cl). Life on Earth produces thousands of different gases (although most in very small quantities). Some might be produced and/or accumulate in an exo-Earth atmosphere to high levels, depending on the exo-Earth ecology and surface and atmospheric chemistry.To maximize our chances of recognizing biosignature gases, we promote the concept that all stable and potentially volatile molecules should initially be considered as viable biosignature gases. We present a new approach to the subject of biosignature gases by systematically constructing lists of volatile molecules in different categories. An exhaustive list up to six non-H atoms is presented, totaling about 14,000 molecules. About 2500 of these are CNOPSH compounds. An approach for extending the list to larger molecules is described. We further show that about one-fourth of CNOPSH molecules (again, up to N = 6 non-H atoms) are known to be produced by life on Earth. The list can be used to study classes of chemicals that might be potential biosignature gases, considering their accumulation and possible false positives on exoplanets with atmospheres and surface environments different from Earth's. The list can also be used for terrestrial biochemistry applications, some examples of which are provided. We provide an online community usage database to serve as a registry for volatile molecules including biogenic compounds.

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Section: Gases Produced By Life (On Earth)mentioning

confidence: 99%

Toward a List of Molecules as Potential Biosignature Gases for the Search for Life on Exoplanets and Applications to Terrestrial Biochemistry

2016

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“…In fact, the chemicals produced by life on Earth are numbering in the hundreds of thousands (estimated from plant natural products (Gunatilaka 2012), microbial natural products (Sanchez et al 2012) and marine natural products (Fusetani 2012)). However, only a subset of hundreds is volatile enough to enter the atmosphere at more than trace concentrations.…”

Section: The Search For Biosignature Gasesmentioning

confidence: 99%

The search for habitable planets with biosignature gases framed by a ‘Biosignature Drake Equation’

Seager

2017

International Journal of Astrobiology

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The discovery of thousands of exoplanets in the last two decades has uncovered a wide diversity of planets that are very different from those in our own Solar System. Ideas for how to detect signs of life in the variety of planetary possibilities, by way of biosignature gases, are expanding, although they largely remain grounded in study of familiar gases produced by life on Earth and how they appear in Earth's spectrum as viewed as an exoplanet. What are the chances we will be able to observe and identify biosignature gases on exoplanets in the coming two decades? I review the status of the search for habitable planets and biosignature gases framed by a ‘Biosignature Drake Equation’.

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“…Spinosad and milbemycin also have insecticidal activity. Spinosad is a combination of spinosyn A and D, which are both produced by Saccharopolyspora spinosa and have insecticidal activity against livestock external parasites via the disruption of nicotinic acetylcholine receptors (Sanchez et al, 2012). Milbemycin is an isolated fermentation product of S. hygroscopicus subsp.…”

Section: Biological Activities Of Natural Products and Biologicsmentioning

confidence: 99%

“…Lipstatin (16; Figure 3 and Table 1) is a pancreatic lipase inhibitor produced by Streptomyces toxytricini that is used to combat obesity and diabetes by interfering with the gastrointestinal absorption of fat (Weibel et al, 1987). Lipstatin contains a beta-lactone structure that is likely responsible for irreversibly binding to the active site of lipase (Sanchez et al, 2012).…”

Section: Biological Activities Of Natural Products and Biologicsmentioning

confidence: 99%

“…The discovery of penicillin from Penicillium notatum by Alexander Fleming in 1928 marked a significant shift from plants to microorganisms as a source of natural products (Fleming, 1944). Since then, microorganism-derived compounds have been utilized in medicine, agriculture, food industry and scientific research (Sanchez et al, 2012). The early years of antibiotic research discovered streptomycin from Streptomyces griseus (Waksman et al, 1946), chloramphenicol from Streptomyces venezuelae (Duggar, 1948), chlortetracycline from Streptomyces aureofaciens (Ehrlich et al, 1947), cephalosporin C from Cephalosporium acremonium (Newton and Abraham, 1955), erythromycin from Saccharopolyspora erythraea and vancomycin from Amycolatopsis orientalis (Geraci et al, 1956).…”

Section: Introductionmentioning

confidence: 99%

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A Review of the Microbial Production of Bioactive Natural Products and Biologics

et al. 2019

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A variety of organisms, such as bacteria, fungi, and plants, produce secondary metabolites, also known as natural products. Natural products have been a prolific source and an inspiration for numerous medical agents with widely divergent chemical structures and biological activities, including antimicrobial, immunosuppressive, anticancer, and anti-inflammatory activities, many of which have been developed as treatments and have potential therapeutic applications for human diseases. Aside from natural products, the recent development of recombinant DNA technology has sparked the development of a wide array of biopharmaceutical products, such as recombinant proteins, offering significant advances in treating a broad spectrum of medical illnesses and conditions. Herein, we will introduce the structures and diverse biological activities of natural products and recombinant proteins that have been exploited as valuable molecules in medicine, agriculture and insect control. In addition, we will explore past and ongoing efforts along with achievements in the development of robust and promising microorganisms as cell factories to produce biologically active molecules. Furthermore, we will review multi-disciplinary and comprehensive engineering approaches directed at improving yields of microbial production of natural products and proteins and generating novel molecules. Throughout this article, we will suggest ways in which microbial-derived biologically active molecular entities and their analogs could continue to inspire the development of new therapeutic agents in academia and industry.

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Microbial Natural Products

Cited by 15 publications

References 83 publications

Toward a List of Molecules as Potential Biosignature Gases for the Search for Life on Exoplanets and Applications to Terrestrial Biochemistry

Toward a List of Molecules as Potential Biosignature Gases for the Search for Life on Exoplanets and Applications to Terrestrial Biochemistry

The search for habitable planets with biosignature gases framed by a ‘Biosignature Drake Equation’

A Review of the Microbial Production of Bioactive Natural Products and Biologics

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