Microbial network signatures of early colonizers in infants with eczema

Huang, Linjie; Pan, Guihua; Feng, Yifei; Fan, Zijing; Ma, Kai; Wang, Runxin; Wang, Guangxian; Huang, Guangye; Huang, Sixia; Hou, Yuhui; Han, Mulan; Xie, Liwei; Ma, Ying

doi:10.1002/imt2.90

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…Based on the analysis of 13,776 fecal samples or datasets from 1,956 infants between 1 and 3 years of age, we identified a deterministic developmental process of infant gut microbiome ( Xiao et al, 2021 ). As infants grow up, microbiome with unstable community structure and low microbiome maturation gradually turn to that characterized by higher diversity and stronger connections ( Huang et al, 2023 ), namely from stages of immaturity to maturity. During this mature or stable phase, the infants’ gut microbiota was mainly driven by Bifidobacterium , Bacteroides, and Prevotella and the dominated microbes will not change as much as developmental and transitional phase ( Xiao et al, 2021 ).…”

Section: Assessment Of Infant Development and Nutritional Status Base...mentioning

confidence: 99%

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Gao

Wang

2023

Protein &Amp; Cell

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Microbes are commonly sensitive to shifts in the physiological and pathological state of their hosts, including mothers and babies. From this perspective, the microbiome may be a good indicator for diseases during pregnancy and has the potential to be used for perinatal health monitoring. This is embodied in the application of microbiome from multi body sites for auxiliary diagnosis, early prediction, prolonged monitoring, and retrospective diagnosis of pregnancy and infant complications, as well as nutrition management and health products developments of mothers and babies. Here we summarized the progress in these areas and explained that the microbiome of different body sites is sensitive to different diseases and their microbial biomarkers may overlap between each other, thus we need to make a diagnosis prudently for those diseases. Based on the microbiome variances and additional anthropometric and physical data, individualized responses of mothers and neonates to meals and probiotics/prebiotics were predictable, which is of importance for precise nutrition and probiotics/prebiotics managements and developments. Although a great deal of encouraging performance was manifested in previous studies, the efficacy could be further improved by combining multi-aspect data such as multi-omics and time series analysis in the future. This review reconceptualizes maternal and infant health from a microbiome perspective, and the knowledge in it may inspire the development of new options for the prevention and treatment of adverse pregnancy outcomes and bring a leap forward in perinatal health care.

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Section: Assessment Of Infant Development and Nutritional Status Base...mentioning

confidence: 99%

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Gao

Wang

2023

Protein &Amp; Cell

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Effects of breast-fed infants-derived Limosilactobacillus reuteri and Bifidobacterium breve ameliorate DSS-induced colitis in mice

Huang,

Liu,

Xiao

et al. 2024

iScience

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Microbial network signatures of early colonizers in infants with eczema

Abstract: In this longitudinal cohort study, our results demonstrated that there are rhythmic changes in gut microbial network signatures in early life, and healthy infants adopt more complex and stable network structure in their gut microbiota than that of the infants with eczema.

Cited by 2 publications

References 49 publications

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care

Effects of breast-fed infants-derived Limosilactobacillus reuteri and Bifidobacterium breve ameliorate DSS-induced colitis in mice

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