Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways

Fernández-Millán, Elisa; Ramos, Sonia; Álvarez, Carmen; Bravo, Laura; Goya, Luis; Martín, Maria Ángeles

doi:10.1016/j.fct.2014.01.044

Cited by 76 publications

(71 citation statements)

References 46 publications

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“…A potential limitation of the study is the use of native phenolic compounds present in the powders instead of their microbiota/liver metabolites. Current evidences indicate that flavonoid metabolites produced by colonic microbiota, especially those of phenolic acids (di-and mono-hydroxylated phenylpropionic, phenylacetic and benzoic acids), could possess biological properties and therefore potential health beneficial effects (Fernández-Millán et al, 2014). These results support the hypothesis that not only food polyphenols but also their microbial metabolites must be taken into account when assessing the impact of polyphenols on health.…”

Section: Discussionsupporting

confidence: 54%

Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

Martín

Ramos

Mateos

et al. 2015

Food Research International

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Section: Discussionsupporting

confidence: 54%

Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

Martín

Ramos

Mateos

et al. 2015

Food Research International

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“…In addition, EC inhibited the IL‐1β‐induced expression of inducible nitric oxide synthase by blocking the nuclear localization of the p65‐nuclear factor kappa B (NF‐κB) and partly restored the insulin in RINm5F cells . Likewise, EC promoted glucose‐stimulated insulin secretion in rat β‐pancreatic INS‐1E cells , and a similar effect was observed with the microbial‐derived flavonoid metabolites 3,4‐dihydroxyphenylacetic acid (5 μM), and 3‐hydroxyphenylpropionic acid (1 μM) in the same cell line as well as in rat pancreatic islets . Nevertheless, it has been showed that at lower concentrations EC and procyanidin B2 (0.01–0.32 μM) inhibited and did not modify insulin secretion, respectively, in INS‐1E cells .…”

Section: Antidiabetic Actions Of Cocoa Flavonoidsmentioning

confidence: 74%

“…In addition, flavanol oligomers and polymers that are not absorbed through the gut barrier (large proanthocyanidins appear to be 10‐ to 100‐fold less absorbed ) could be metabolized by the intestinal microbiota into different phenolic acids of low molecular weight, which are more bioavailable, and might be well absorbed through the colon and exert beneficial effects . Consequently, the formation of various polyphenol‐derived phenolic acids, such as m‐ hydroxyphenylpropionic acid, m ‐hydroxyphenylacetic acid, as well as m ‐hydroxybenzoic acid, were shown to be increased in humans and rats after cocoa consumption and to possess an antidiabetic potential by in vitro studies .…”

Section: Cocoa Flavonoidsmentioning

confidence: 99%

Antidiabetic actions of cocoa flavanols

Martín

Goya

Ramos

2016

Molecular Nutrition Food Res

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Prevention of diabetes mellitus type 2 (DMT2) through the diet is receiving a growing interest and cocoa because of its polyphenolic compounds, mainly flavanols, has become an important potential chemopreventive natural agent. Cocoa and its main flavanols might contribute to prevent or delay diabetes mellitus type 2 by modulating insulin secretion in β-pancreatic cells and targeting insulin-sensitive tissues because of their insulin-like activity or through the regulation of key proteins of the insulin signaling route. Among other actions, cocoa flavanols have been proved to enhance glucose uptake through the promotion of glucose transport, to repress glucose production, or to improve lipid metabolism. Nevertheless, the molecular mechanisms of action involved in these effects are not fully understood and many points remain to be clarified. This review provides insights into the molecular machinery of the chemopreventive activity of cocoa and its flavanols by compiling cell culture and animal models studies, as well as evidence from human interventional trials.

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“…The global prevalence of DM has risen to 8.5% amounting ∼422 million in 2014 (World Health Organization [WHO], 2016). It has been predicted that, the incidence of this syndrome would be more than double by the year of 2030 (Fernández-Millán et al, 2014). Amongst all diagnosed cases, type 2 diabetes mellitus (T2DM) is more rampant and comprising ∼90–95% of total diabetic cases (Khanra et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation

et al. 2017

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Persistent hyperglycemia, impairment of redox status and establishment of inflammatory pathophysiology integrally play important role in the pathogenesis of diabetic cardiomyopathy (DC). Present study examined the therapeutic potential of protocatechuic acid isolated from the Sansevieria roxburghiana rhizomes against DC employing rodent model of type 2 diabetes (T2D). T2D was induced by high fat diet + a low-single dose of streptozotocin (35 mg/kg, i.p.). T2D rats exhibited significantly (p < 0.01) high fasting blood glucose level. Alteration in serum lipid profile (p < 0.01) and increased levels of lactate dehydrogenase (p < 0.01) and creatine kinase (p < 0.01) in the sera of T2D rats revealed the occurrence of hyperlipidemia and diabetic pathophysiology. A significantly (p < 0.01) high levels of serum C-reactive protein and pro-inflammatory mediators revealed the establishment of inflammatory occurrence in T2D rats. Besides, significantly high levels of troponins in the sera revealed the establishment of cardiac dysfunctions in T2D rats. However, protocatechuic acid (50 and 100 mg/kg, p.o.) treatment could significantly reverse the changes in serum biochemical parameters related to cardiac dysfunctions. Molecular mechanism studies demonstrated impairment of signaling cascade, IRS1/PI3K/Akt/AMPK/p 38/GLUT4, in glucose metabolism in the skeletal muscle of T2D rats. Significant (p < 0.01) activation of polyol pathway, enhanced production of AGEs, oxidative stress and up-regulation of inflammatory signaling cascades (PKC/NF-κB/PARP) were observed in the myocardial tissue of T2D rats. However, protocatechuic acid (50 and 100 mg/kg, p.o.) treatment could significantly (p < 0.05–0.01) stimulate glucose metabolism in skeletal muscle, regulated glycemic and lipid status, reduced the secretion of pro-inflammatory cytokines, and restored the myocardial physiology in T2D rats near to normalcy. Histological assessments were also in agreement with the above findings. In silico molecular docking study again supported the interactions of protocatechuic acid with different signaling molecules, PI3K, IRS, Akt, AMPK PKC, NF-κB and PARP, involved in glucose utilization and inflammatory pathophysiology. In silico ADME study predicted that protocatechuic acid would support the drug-likeness character. Combining all, results would suggest a possibility of protocatechuic acid to be a new therapeutic agent for DC in future.

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Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways

Cited by 76 publications

References 46 publications

Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture. Response of the antioxidant defenses and regulation of signaling pathways

Antidiabetic actions of cocoa flavanols

Protocatechuic Acid, a Phenolic from Sansevieria roxburghiana Leaves, Suppresses Diabetic Cardiomyopathy via Stimulating Glucose Metabolism, Ameliorating Oxidative Stress, and Inhibiting Inflammation

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