Microbial production of astilbin, a bioactive rhamnosylated flavanonol, from taxifolin

Thuần, Nguyễn Huy; Malla, Sailesh; Trung, Nguyễn Thành; Dhakal, Dipesh; Pokhrel, Anaya Raj; Chu, Luan Luong; Sohng, Jae Kyung

doi:10.1007/s11274-017-2208-7

Cited by 16 publications

(16 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Production of flavonoids by microorganisms was reported, previously. Genetically-engineered microorganisms such as Escherichia coli BL21 can be used for the production of flavonoids such as astilbin, quercitrin for industry [ 18 , 19 ]. Conversion of rutin to quercetin using microorganisms such as Paenibacillus glucanolyticus is one of the approaches to produce quercetin [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical and molecular characterization of metabolites from Flavobacterium sp.

et al. 2018

View full text Add to dashboard Cite

In this study, a Flavobacterium sp. is isolated from natural spring, and identified using molecular techniques. Extracellular and intracellular secondary metabolites are identified using solid phase microextraction gas chromatography-mass spectrometry and ultra performance liquid chromatography. Cytotoxic activity of the extracellular compounds produced by the Flavobacterium sp. and quercetin as the standard are measured using ECV304 human endothelial cells in vitro. Our results show that Flavobacterim sp. isolate has the highest percentage of similarity with Flavobacterium cheonhonense strain ARSA-15 (99%). Quercetin is detected as the major extracellular compound produced by the Flavobacterium sp. Methanol extract of Flavobacterium sp. resulted in a higher cell viability results when compared to DMSO extracts. Computational chemistry approach was used and it has been found that polar solvent (methanol) contributed to higher antioxidant activity. In conclusion, Flavobacterium sp. can be used to produce quercetin for industrial purposes.

show abstract

Section: Discussionmentioning

confidence: 99%

Chemical and molecular characterization of metabolites from Flavobacterium sp.

et al. 2018

View full text Add to dashboard Cite

show abstract

“…However, for their possible pharmaceutical use, the astilbin available from extraction is not sufficient. An efficient process to obtain astilbin from taxifolin relied on microbial fermentation in genetically-engineered Escherichia coli ( Scheme 44 ) [ 394 ].…”

Section: Polyphenolsmentioning

confidence: 99%

Tailored Functionalization of Natural Phenols to Improve Biological Activity

et al. 2021

View full text Add to dashboard Cite

Phenols are widespread in nature, being the major components of several plants and essential oils. Natural phenols’ anti-microbial, anti-bacterial, anti-oxidant, pharmacological and nutritional properties are, nowadays, well established. Hence, given their peculiar biological role, numerous studies are currently ongoing to overcome their limitations, as well as to enhance their activity. In this review, the functionalization of selected natural phenols is critically examined, mainly highlighting their improved bioactivity after the proper chemical transformations. In particular, functionalization of the most abundant naturally occurring monophenols, diphenols, lipidic phenols, phenolic acids, polyphenols and curcumin derivatives is explored.

show abstract

“…Glycosylation is catalyzed by UDP-glycosyltransferase (UGTs), which transfers a sugar moiety from a UDP sugar donor to the hydroxyl groups of ginsenosides. The glycosylation reaction has a significant impact on the solubility, stability, and biological activity of ginsenosides (Pandey et al, 2018;Thuan et al, 2018). A large number of UGTs are present in plants, such as A. thaliana, Glycine max, P. ginseng, and Medicago truncatula (Rahimi et al, 2019).…”

Section: Expression Of Heterologous Genes From Plants and Microbesmentioning

confidence: 99%

Recent Advances in the Metabolic Engineering of Yeasts for Ginsenoside Biosynthesis

Chu

Montecillo

Bae

2020

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Ginsenosides are a group of glycosylated triterpenes isolated from Panax species. Ginsenosides are promising candidates for the prevention and treatment of cancer as well as food additives. However, owing to a lack of efficient approaches for ginsenoside production from plants and chemical synthesis, ginsenosides may not yet have reached their full potential as medicinal resources. In recent years, an alternative approach for ginsenoside production has been developed using the model yeast Saccharomyces cerevisiae and non-conventional yeasts such as Yarrowia lipolytica and Pichia pastoris. In this review, various metabolic engineering strategies, including heterologous gene expression, balancing, and increasing metabolic flux, and enzyme engineering, have been described as recent advanced engineering techniques for improving ginsenoside production. Furthermore, the usefulness of a systems approach and fermentation strategy has been presented. Finally, the present challenges and future research direction for industrial cell factories have been discussed.

show abstract

Microbial production of astilbin, a bioactive rhamnosylated flavanonol, from taxifolin

Cited by 16 publications

References 59 publications

Chemical and molecular characterization of metabolites from Flavobacterium sp.

Chemical and molecular characterization of metabolites from Flavobacterium sp.

Tailored Functionalization of Natural Phenols to Improve Biological Activity

Recent Advances in the Metabolic Engineering of Yeasts for Ginsenoside Biosynthesis

Contact Info

Product

Resources

About