Microbial signature of intestine in children with allergic rhinitis

Abstract

IntroductionPrevious studies have found that unique patterns of gut microbial colonization in infancy associated with the development of allergic diseases. However, there is no research on the gut microbiota characteristics of AR children in Chinese Mainland.ObjectiveTo investigate the changes of gut microbial of AR children in Chinese Mainland and evaluate the correlation between gut microbial and clinical indexes.MethodsIn this clinical study, fecal samples from 24 AR children and 25 healthy control children (HCs) were comparative via next generation sequencing of the V3-V4 regions of the 16S rRNA gene. Analyzed the relationship between clinical features and gut microbial using Spearman correlation.ResultsCompared to HCs, AR children showed significant decreases in Shannon index and significant increases in Simpson index at both the family and genera levels (all p < 0.05). In terms of bacterial composition, at the phylum level, AR children had higher abundance of Bacteroidetes than that in the HCs group (p < 0.05) and were significantly positively correlated with TNSS (p < 0.05). At the family level, AR children had higher abundance of Prevotellaceae and Enterobacteriaceae higher than that in the HCs group (all p < 0.05) and had a significantly positive correlation with TNSS, eosinophils (EOS) and total immunoglobulin E (tIgE) (all p < 0.05). At the genus level, reduced abundance of Agathobacter, Parasutterella, Roseburia and Subdoligranulum were also observed in the AR cohorts compared to HCs (all p < 0.05) and significantly negatively associated with TNSS, EOS, tIgE, QOL, and FeNO (all p < 0.05).ConclusionAR children in Chinese Mainland were characterized by reduced microbial diversity and distinguished microbial characteristics in comparison with HCs. The observations of this study offer proof that distinctive gut microbiota profiles were present in AR children and necessitate further investigation in the form of mechanistic studies.

Genetic associations between gut microbiota and allergic rhinitis: an LDSC and MR analysis

“…A reduction in Firmicutes coupled with an increase in Bacteroidetes results in diminished production of SCFAs. This may enhance intestinal permeability, thereby triggering an inflammatory response and potentially elevating the risk of allergic conditions (Yamaguchi et al, 2023;Zhang P. et al, 2023).…”

A review of common influencing factors and possible mechanisms associated with allergic diseases complicating tic disorders in children

“…A cohort study in Ecuador showed that increased fecal abundance of Streptococcus and Bacteroidetes and decreased abundance of Bifidobacterium and Ruminococcus in children as young as 3 months old was associated with allergy and wheezing at age 5 years ( 88 ). Research by Zhang et al showed that the diversity of gut microbial in children with AR was reduced and the abundance of Bacteroidetes was significantly increased, and changes in the gut microbial were correlated with clinical symptoms ( 89 ). The gut microbiota plays a crucial role in the immune system by influencing the development of either responsive or tolerant reactions to various antigens.…”