Microbial Stabilizers in Food Processing

Devi, Bindu; Devi, Sunita; Sood, Diksha; Arya, Priyanka

doi:10.1007/978-981-19-5711-6_6

Cited by 4 publications

(3 citation statements)

References 77 publications

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“…SIRT1 activity was quantified with an SIRT1 fluorometric assay kit (Abcam ab 156065, UK) as per the manufacturer's instructions and as described in our previous study. [26] Measurement of fluorescence intensity was carried out at 340/360 nm excitation and emission using a microplate reader (BMG LABTECH CLARIO star, Germany).…”

Section: Sirt1 Activitymentioning

confidence: 99%

“…[24] Recently, we have reviewed the role of taurine in regulating lipid metabolism via various molecular targets. [26] Despite a plethora of reports, the underlying molecular mechanism for the effects of taurine on hepatic lipid metabolism particularly with respect to SIRT1 mediated signaling pathway remains incompletely understood. A previous study has shown that taurine offers protection against cafeteria diet-induced steatohepatitis in rats via increase in hepatic levels of SIRT1 along with a decrease in levels of fibroblast growth factor-21 (FGF-21), a liver derived hormone.…”

Section: Introductionmentioning

confidence: 99%

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Taurine Activates SIRT1/AMPK/FOXO1 Signaling Pathways to Favorably Regulate Lipid Metabolism in C57BL6 Obese Mice

Karikkakkavil Prakashan,

Muthukumar,

Martin

2024

Molecular Nutrition Food Res

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ScopeThe identification of novel therapeutic agents capable of modulating lipid metabolism holds a promising potential in combating obesity and its associated complications. This study is conducted to evaluate the lipid lowering effect of dietary taurine administration on high‐fat fed C57BL6 mice and to study the mechanism by which taurine impacts lipid metabolism.Methods and resultsC57BL6 mice are grouped into four (n = 6): i) normal diet (ND), ii) a high‐fat diet (HFD), iii) HFD + orlistat (STD), iv) HFD + taurine (TAU) group for 12 weeks. The results show that taurine administration for 12 weeks reduces high fat‐induced weight gain, and liver weight when compared with HFD fed mice. It also improves serum biochemical parameters like total cholesterol and triglycerides. Sirtuin 1 (SIRT1) activity, Nicotinamide adenine dinucleotide (NAD+) levels, SIRT1 mRNA, and protein expression are increased in HFD + TAU diet group as compared to HFD group. Taurine treatment suppresses the expression of lipogenic genes (sterol regulatory element binding protein 1c [SREBP1c], fatty acid synthase [FAS], Peroxisome proliferator‐activated receptor gamma [PPARγ]) and increases the expression of β‐oxidation (peroxisome proliferator‐activated receptor alpha [PPARα], liver x receptor beta [LXRβ], peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha [PGC1α], AMP‐activated protein kinase [AMPK]) and lipolytic (forkhead box protein O1 [FOXO1]) genes. Further, taurine mitigates hepatic inflammation by suppressing nuclear factor kappa B (NF‐κB) gene expression and pro‐inflammatory cytokine markers (IL‐6, IL‐1β, and TNFα).ConclusionTaurine exerts lipid lowering effects through activating SIRT1/AMPK/FOXO1 signaling pathways and regulating their downstream targets.

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Section: Sirt1 Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Taurine Activates SIRT1/AMPK/FOXO1 Signaling Pathways to Favorably Regulate Lipid Metabolism in C57BL6 Obese Mice

Karikkakkavil Prakashan,

Muthukumar,

Martin

2024

Molecular Nutrition Food Res

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“…Xanthan gum is a water-soluble EPS, and it is the earliest bacterial EPS to be produced via aerobic fermentation of simple sugars by Xanthomonas campestris in stirred tank fermenters [ 2 ]. It is also the second microbial EPS to receive FDA approval for use as a thickener and stabilizer in food additives [ 4 ]. The structure of xanthan features a 1,4-linked β- d -glucose backbone, which has trisaccharide side chains at alternate glucose residues containing a glucuronic acid residue bridging two mannose units at the C (3) position.…”

Section: Introductionmentioning

confidence: 99%