Microbial transformation of mycophenolic acid

Biotransformations of Imbricatolic Acid by Aspergillus niger and Rhizopus nigricans Cultures

“…Fractions 1-9 contained no compounds of interest and were discarded. Fractions 10-18 yielded some 80 mg of imbricatolic acid (1), while fractions 26-28 afforded 500 mg of mycophenolic acid (4) [26] and the pooled fractions 29-46 contained 10.5 mg of 3-hydroxymycophenolic acid (5) [33,34]. The spectroscopic of the isolated compounds were in agreement with the structures and with published data.…”

“…[32]. On the other hand, 3-hydroxymycophenolic acid (5) was obtained as a microbial transformation product of mycophenolic acid [33,34]. The total synthesis of mycophenolic acid has been reported [26].…”

Host−Guest Chemistry and Physicochemical Properties of the Dendrimer−Mycophenolic Acid Complex

“…However, the peaks for protons d and d′ are overlapped for the G5 dendrimer in aqueous solutions, and the chemical shift of proton b′ is similar with that of proton c. Therefore, only four broad 1 H peaks are observed in the 1 H NMR spectrum of a G5 dendrimer in D 2 O (Figure ) . The 1 H NMR spectrum of MPA in D 2 O shows seven kinds of protons − (Figure S1 in the Supporting Information), the methyl protons (7′ and 10: δ H 1.74 ppm for 7′, singlet; and δ H 2.08 ppm for 10, singlet) at high field, vinyl protons (−CCH−, 2′, triplet, δ H = 5.25 ppm) and methylene protons (−CH 2 −O−C(O)−, 3, singlet, δ H = 5.14 ppm) at low field, the oxymethyl group (CH 3 −O−, 12, singlet, δ H = 3.75 ppm) at a much lower field than other methyl groups, and other methylene protons (1′ and 4′/5′: 1′, doublet, δ H = 3.36/3.34 ppm and 4′/5′, multiplet, δ H = 2.21 ppm) adjacent to the methylene protons (a−d) of dendrimers. The assignment and labeling of protons in the repetitive unit of the G5 dendrimer and MPA molecule are shown in Scheme .…”

“…However, the peaks for protons d and d′ are overlapped for the G5 dendrimer in aqueous solutions, and the chemical shift of proton b′ is similar with that of proton c. Therefore, only four broad 1 H peaks are observed in the 1 H NMR spectrum of a G5 dendrimer in D 2 O (Figure 1). 38 The 1 H NMR spectrum of MPA in D 2 O shows seven kinds of protons [45][46][47] (Figure S1 in the Supporting Information), the methyl protons (7′ and 10: δ dendrimer were induced by the addition of MPA (Figure 1a-h).…”

Bioactive Natural Products from the Marine-Derived Penicillium brevicompactum OUCMDZ-4920

“…为此, 我们对采自南海 68 m 深的海底沉积物 进行了菌株分离, 获得一株青霉菌 OUCMDZ-4920, 该 青霉菌的小试发酵产物对白色念珠菌表现出了较强的 抑菌活性(浓度为 1 mg/mL 时的抑菌圈直径达 2. 甲基-5-氧亚基-2-四氢呋喃基)乙基]-5-甲氧基-4-甲基异 苯并呋喃-1(3H)-酮、 霉酚酸(3)、 3-羟基霉酚酸(4) [4] 、 (S)-2-甲基-4-[5-羟基-7-甲氧基-4-甲基-1-氧亚基-6-(1,3-二氢 异苯并呋喃基)]丁酸(5) [5] 、norpestaphthalides A (6)和 B (7) [6] 、5,7-二甲氧基-4-甲基异苯并呋喃-1(3H)-酮(8) [5] [7] 、 brevianamides A (10) [8,9] 和 E (11) [10,11] . 化合物 3 可抑制 等结构片段, 紫外光谱在 λ max 220, 248, 300 nm 处的吸 收 带 表 明 结 构 中 含 有 苯 并 呋 喃 酮 色 团 , 与 霉 酚 酸 (mycophenolic acid, 3)的紫外吸收相似 [12] .…”