Microbial transformation of squalene: Formation of a novel ketone from squalene by a Rhodococcus sp.

Setchell, Christine H.; Bonner, Jane F.; Wright, S. J. L.; Caunt, P.; Baker, Peter B.

doi:10.1007/bf00252699

Cited by 5 publications

(1 citation statement)

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“…Corynebacterium sp. Rhodococcus sp., which could use squalene as sole carbon source, yielded a single major transformation product identified as squalen-12-one (8), an , -unsaturated ketone [29] (Fig. Squalene (1) was also oxidized to squalenedioic acid (7) by Nocardia (BPM 1613) [27] and Corynebacterium sp.…”

Section: Acyclic Triterpenesmentioning

confidence: 99%

Microbial Transformation of Triterpenoids

Parra¹,

Rivas²,

Garcı́a-Granados³

et al. 2009

MROC

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Microbial transformation of triterpenoids has provided new derivatives that are potentially useful for pharmacological studies. In these biotransformation processes, several reactions that are difficult to achieve by chemical means have been accomplished, such as: introduction of hydroxyl groups into remote positions of the molecules; selective cleavage of the side chains of tetra-cyclic terpenoids to produce C19 steroids; regioselective glycosidic transfer reactions; selective ring cleavage through a Baeyer-Villiger-type oxidation to render seco-triterpenoids; and carbon skeleton rearrangements involving a methyl group migration. These biotransformations have also been used as in vitro models to mimic and predict the mammalian metabolism of biologically active triterpenoids.

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Section: Acyclic Triterpenesmentioning

confidence: 99%

Microbial Transformation of Triterpenoids

Parra¹,

Rivas²,

Garcı́a-Granados³

et al. 2009

MROC

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Squalene – biochemistry, molecular biology, process biotechnology, and applications

Spanova

Daum

2011

Euro J Lipid Sci & Tech

228

168

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Squalene is a natural triterpene and an important intermediate of sterol and hopanoid biosynthesis in various types of cell from bacteria to human. Synthesis and further conversion of squalene are key steps in the metabolism of sterols and related components. Here we summarize the recent knowledge of squalene biochemistry, its molecular properties, and its physiological effects. We compare squalene biosynthetic pathways in different cell types and describe biotechnological strategies to isolate this lipid. Finally, applications of squalene in nutrition, pharmacy, and medicine are discussed.

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