Microbial transformation of widely used pharmaceutical and personal care product compounds

Abstract

F1000 Faculty Reviews are written by members of the prestigious . They are F1000 Faculty commissioned and are peer reviewed before publication to ensure that the final, published version is comprehensive and accessible. The reviewers who approved the final version are listed with their names and affiliations. AbstractPharmaceutical and personal care products (PPCPs) are commonly used chemicals that are increasingly detected in urban-impacted environments, particularly those receiving treated wastewater. PPCPs may have toxicological effects on the macrofauna that are exposed through contaminated water; thus, there is interest in microbially mediated transformations that may degrade PPCPs. This review discusses specific examples of PPCP transformations that may occur in anoxic environments, including O-methylation and O-demethylation. PubMed Abstract | Publisher Full Text | Free Full Text | F1000 Recommendation 2. Kolpin DW, Furlong ET, Meyer MT, et al.: Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ Sci Technol. 2002; 36(6): 1202-11. PubMed Abstract | Publisher Full Text 3. Xia K, Bhandari A, Das K, et al.: Occurrence and fate of pharmaceuticals and personal care products (PPCPs) in biosolids. J Environ Qual. 2005; 34(1): 91-104. PubMed Abstract | Publisher Full Text 4. Jelic A, Rodriguez-Mozaz S, Barceló D, et al.: Impact of in-sewer transformation on 43 pharmaceuticals in a pressurized sewer under anaerobic conditions. Water Res. 2015; 68: 98-108. PubMed Abstract | Publisher Full Text 5. Fick J, Söderström H, Lindberg RH, et al.: Contamination of surface, ground, and drinking water from pharmaceutical production. Environ Toxicol Chem. 2009; 28(12): 2522-7. PubMed Abstract | Publisher Full Text 6. Biel-Maeso M, Corada-Fernández C, Lara-Martín PA: Removal of personal care products (PCPs) in wastewater and sludge treatment and their occurrence in receiving soils. Water Res. 2019; 150: 129-39. PubMed Abstract | Publisher Full Text | F1000 Recommendation 7. Kinney CA, Furlong ET, Zaugg SD, et al.: Survey of organic wastewater contaminants in biosolids destined for land application. Environ Sci Technol. 2006; 40(23): 7207-15. PubMed Abstract | Publisher Full Text 8. Sabourin L, Beck A, Duenk PW, et al.: Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field. Sci Total Environ. 2009; 407(16): 4596-604. PubMed Abstract | Publisher Full Text 9. Watanabe H, Tamura I, Abe R, et al.: Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish). Environ Toxicol Chem. 2016; 35(4): 996-1006. PubMed Abstract | Publisher Full Text 10. Bringolf RB, Heltsley RM, Newton TJ, et al.: Environmental occurrence and reproductive effects of the pharmaceutical fluoxetine in native freshwater mussels. Environ Toxicol Chem. 2010; 29(6): 1311-8. PubMed Abstract | Publisher Full Text 11. Dzieweczynski TL, Campbell BA,...

Status quo on identified transformation products of organic ultraviolet filters and their persistence

“…Conventional and advanced wastewater treatment often does not achieve full mineralization. Recently, the incomplete mineralization of organic contaminants within treatment and the environment progressively moved into environmental researcher's focus [34][35][36][37][38][39]. During transport and on introduction to the environment, various processes may alter the molecules of organic contaminants.…”