Microbiocidal effects of various taurolidine containing catheter lock solutions

Olthof, E.D.; Nijland, Reindert; Gülich, Alexandra Franziska; Wanten, Geert

doi:10.1016/j.clnu.2014.04.023

Cited by 33 publications

(34 citation statements)

References 31 publications

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“…Very recent in vitro tests of taurolidine containing catheterlock solutions have shown a biofilm preventing activity up 0.25 % [33]. In our study, a biofilm formation was inhibited but not completely prevented by taurolidine gels and by MINO.…”

Section: Discussionmentioning

confidence: 55%

In vitro activity of taurolidine gel on bacteria associated with periodontitis

et al. 2015

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Section: Discussionmentioning

confidence: 55%

In vitro activity of taurolidine gel on bacteria associated with periodontitis

et al. 2015

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“…A number of different taurolidine products are available including 2% solution, 1.34% with citrate, and 1.34% with citrate and heparin. An investigation into their relative efficacy [101] showed equal effectiveness in killing Escherichia coli, Staphylococcus aureus and Candida glabrata, with no difference in their effects on the catheter biofilm [101]. In a study of pediatric patients with cancer, Handrup et al found use of taurolidine was associated with reduced risk of CRBSI compared with heparin, but electron microscopy of removed CVC found no difference in intraluminal biofilm formation or catheter colonization [102].…”

Section: (Loe 3)mentioning

confidence: 99%

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access

Braegger¹,

Bronský²,

Cai³

et al. 2018

Clinical Nutrition

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“…Taurolidine, a derivative of the amino acid taurine, is an antimicrobial agent showing a broad spectrum of antimicrobial activity against both bacteria and fungi [ 87 , 88 ]. A meta-analysis of 6 small studies in patients with different catheter types and taurolidine concentrations suggest that taurolidine as locking solution reduces the CRBSI incidence without obvious adverse effects and bacterial resistance [ 89 ].…”

Section: Lockingmentioning

confidence: 99%

Flushing and Locking of Venous Catheters: Available Evidence and Evidence Deficit

Goossens

2015

Nursing Research and Practice

138

185

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Flushing and locking of intravenous catheters are thought to be essential in the prevention of occlusion. The clinical sign of an occlusion is catheter malfunction and flushing is strongly recommended to ensure a well-functioning catheter. Therefore fluid dynamics, flushing techniques, and sufficient flushing volumes are important matters in adequate flushing in all catheter types. If a catheter is not in use, it is locked. For years, it has been thought that the catheter has to be filled with an anticoagulant to prevent catheter occlusion. Heparin has played a key role in locking venous catheters. However, the high number of risks associated with heparin forces us to look for alternatives. A long time ago, 0.9% sodium chloride was already introduced as locking solution in peripheral cannulas. More recently, a 0.9% sodium chloride lock has also been investigated in other types of catheters. Thrombolytic agents have also been studied as a locking solution because their antithrombotic effect was suggested as superior to heparin. Other catheter lock solutions focus on the anti-infective properties of the locks such as antibiotics and chelating agents. Still, the most effective locking solution will depend on the catheter type and the patient's condition.

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Microbiocidal effects of various taurolidine containing catheter lock solutions

Cited by 33 publications

References 31 publications

In vitro activity of taurolidine gel on bacteria associated with periodontitis

In vitro activity of taurolidine gel on bacteria associated with periodontitis

ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access

Flushing and Locking of Venous Catheters: Available Evidence and Evidence Deficit

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