Microbiolgical research at the centre for tropical veterinary medicine (CTVM)

Scott, G. R.

doi:10.1007/bf02250726

Cited by 3 publications

(2 citation statements)

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“…Similar observations have been reported in E. equi infection in horses [ 18 ] and in E. canis infection in dogs [ 16 ]. However, the antibody titre is not a good criterion for assessing recovery from the persistent state of the E. phagocytophila infection, both due to individual variation in immune response and persistence of antibody titre in infected lambs [ 22 , 19 , 25 ]. Earlier studies also show that the IFA-test can not be used in assessing clearance of E. canis after antibiotic treatment, since dogs remain IFA positive for months after clearance of the organism [ 16 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Two Different Oxytetracycline Treatments in Experimental Ehrlichia phagocytophilaInfected Lambs

Stuen¹,

Bergström

2001

Acta Vet Scand

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The effect of 2 different oxytetracycline treatments in acute E. phagocytophila infected lambs was investigated. Twenty 5-month-old lambs of the Dala and Rygja breeds were used. Ten lambs were inoculated intravenously with a stabilate of an ovine E. phagocytophila strain. On the third day of fever, 4 lambs were given long-acting oxytetracycline (Terramycin prolongatum vet®, Pfizer) (20 mg/kg) intramuscularly and another 4 lambs were given short-acting oxytetracycline (Terramycin vet®, Pfizer) (10 mg/kg) intravenously for 5 consecutive days. The lambs were examined for the presence of Ehrlichia infection by blood smear evaluation, polymerase chain reaction (PCR) and antibody titre against E. equi. One month after the last antibiotic treatment, 250 ml citrate blood from each of these lambs were inoculated into each of 10 susceptible lambs, which were observed during the following 6 weeks. The results indicate that oxytetracycline given in the acute stage of the infection may effectively teminate the development of fever, rickettsemia and weight reduction in E. phagocytophila infected lambs. No difference was observed between the 2 treatment groups. However, at least 3 of 8 antibiotic treated lambs (37.5%) were still infected with granulocytic Ehrlichia 3 months after treatment.

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Section: Discussionmentioning

confidence: 99%

The Effect of Two Different Oxytetracycline Treatments in Experimental Ehrlichia phagocytophilaInfected Lambs

Stuen¹,

Bergström

2001

Acta Vet Scand

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“…The observation of pre‐parturition increases in antibody titres against orf virus suggested the possible activation of cryptic virus (Scott and Maeda 1978). Nevertheless, attempts to potentiate a subclinical infection in previously infected sheep have hitherto failed, although the virus has been recovered from overt orf lesions observed on rare occasions in a few productive ewes from which virus had been isolated when the ewes were lambs (Scott and Osman 1974). This paper describes evidence that ewes with no clinical signs of orf transmitted the disease to susceptible sheep.…”

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confidence: 99%

Natural transmission of orf virus from clinically normal ewes to orf‐naive sheep

et al. 1996

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The apparent natural transmission of orf virus from clinically normal ewes to susceptible sheep was observed during a border disease vaccine experiment. The 14 susceptible sheep were persistently infected with border disease virus and had been reared indoors in isolation from other sheep since birth. Their ages ranged from two to four years and they were housed in two groups; group 1 consisted of four sheep persistently infected with the Moredun strain of border disease virus and group 2 consisted of 10 sheep persistently infected with the Oban strain of the virus. On day 0, six sheep were removed from group 2 and rehoused. To the remaining four sheep in each group were added eight four- to six-year-old pregnant conventionally reared ewes at 48 days gestation. Fourteen days later the four sheep in group 1 were moved to another pen housing eight similar five-year-old pregnant ewes at 48 days' gestation, and the four sheep from group 2 were rehoused with their original stallmates. Twenty-one days later lip lesions typical of orf were first observed on the sheep from both groups and the disease spread to all the sheep persistently infected with border disease virus over the next four weeks. Virological and serological evidence demonstrated that the source of infection for the sheep was almost certainly the conventionally reared ewes, on which no lesions resembling orf were observed at any time during the study.

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Tropical Avian Diseases

Xie¹

2023

Fowler' S Zoo and Wild Animal Medicine Current Therapy, Volume 10

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Microbiolgical research at the centre for tropical veterinary medicine (CTVM)

Cited by 3 publications

References 16 publications

The Effect of Two Different Oxytetracycline Treatments in Experimental Ehrlichia phagocytophilaInfected Lambs

The Effect of Two Different Oxytetracycline Treatments in Experimental Ehrlichia phagocytophilaInfected Lambs

Natural transmission of orf virus from clinically normal ewes to orf‐naive sheep

Tropical Avian Diseases

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