Microbiologic spectrum and susceptibility of isolates in acute postcataract surgery endophthalmitis: are they same as they were more than a decade ago?

Jindal, Animesh; Pathengay, Avinash; Mithal, Kopal; Jalali, Subhadra; Mathai, Annie; Pappuru, Rajeev Reddy; Narayanan, Raja; Chhablani, Jay; Motukupally, Swapna Reddy; Sharma, Savitri; Das, Taraprasad

doi:10.1136/bjophthalmol-2013-304289

Cited by 20 publications

(13 citation statements)

References 6 publications

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“…The antimicrobial susceptibility of the organisms is comparable to that of the same organisms in different clinical settings like acute post-cataract endophthalmitis and post-traumatic endophthalmitis in the same geographic region. 7 , 8 Gram-positive organisms are most susceptible to vancomycin and Gram-negative organisms to fluoroquinolones and ceftazidime. Low susceptibility of Gram-negative organisms to amikacin was due to B. cepacia being the most common cause and they have been shown to be less susceptible to amikacin as compared to ceftazidime and ciprofloxacin.…”

Section: Discussionmentioning

confidence: 99%

Microbiologic spectrum and susceptibility of isolates in delayed post-cataract surgery endophthalmitis

Jindal¹,

Pathengay²,

Jalali³

et al. 2015

OPTH

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The objective of this study was to evaluate the microbiological spectrum and antimicrobial susceptibility of isolates in delayed post-cataract surgery endophthalmitis. A retrospective review of 33 consecutive patients with culture proven delayed post-cataract surgery endophthalmitis was done from January 2006 to March 2013. There were 22 bacterial and eleven fungal cases. Common isolates were Streptococci (seven cases), coagulase-negative staphylococci (five), Gram-negative bacilli (seven), Nocardia (two), Aspergillus (five), Candida (five). Gram-positive cocci were most susceptible to vancomycin and gatifloxacin (91.7%). Gram-negative isolates were most susceptible to ofloxacin (85.7%). Fungi being slow growing organisms are an important cause of delayed post-cataract surgery endophthalmitis.

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Section: Discussionmentioning

confidence: 99%

Microbiologic spectrum and susceptibility of isolates in delayed post-cataract surgery endophthalmitis

Jindal¹,

Pathengay²,

Jalali³

et al. 2015

OPTH

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“…The Chennai group and we also compared the infecting microorganisms in different time periods the Chennai group between 2001 and 2007 and we between 1999 and 2012. [ 4 13 14 ] These studies showed that Gram-negative infection is consistently between 30% and 40% and that P. aeruginosa continues to be the predominant Gram-negative infection [ Table 2 ].…”

Section: Infection Controlmentioning

confidence: 99%

Redefining evidence in the management of acute post-cataract surgery endophthalmitis in India - The 2014 Adenwalla Oration, All India Ophthalmological Society

Das

2017

Indian J Ophthalmol

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The current evidence of postoperative endophthalmitis management in three important components of care-infection control, inflammation control, and prevention was reviewed, and their current relevance and application in an Indian context were evaluated. The publications from India indicated that Gram-negative bacterial and filamentous fungal infections are relatively higher. There are increasing instances of resistance to ceftazidime by Gram-negative microorganisms. Intravitreal dexamethasone limits inflammation in bacterial endophthalmitis when given together with the intravitreal antibiotics. Intracameral antibiotic could reduce postcataract surgery infection at least in less rigorous surgical environment. Systematic collection of data and periodic evaluation of the current practice against the new evidence are necessary to prevent or treat postcataract surgery endophthalmitis.

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“…A single-center review reported an increase in Gram-negative endophthalmitis, but a decrease in fungal endophthalmitis, from 1999 through 2013 [9]. Klebsiella pneumoniae appears to be increasing in prevalence and incidence as a cause of endogenous endophthalmitis, especially in Asia [10].…”

Section: Changes In Microbiology and Antibiotic Susceptibilitiesmentioning

confidence: 99%

Update on the prevention and treatment of endophthalmitis

Schwartz

Flynn

2014

Expert Review of Ophthalmology

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SUMMARY Endophthalmitis remains a rare but serious cause of visual loss. Over time, changes have been noted in endophthalmitis in terms of predominant causes, infecting organisms, and antibiotic susceptibilities. There is controversy regarding the use of intracameral prophylactic antimicrobials during cataract surgery. Alternatively, there appears to be increasing evidence against using routine topical antibiotics for intravitreal injections. There are also increasing reports of multidrug-resistant organisms causing endophthalmitis, but the combination of vancomycin and ceftazidime appears effective for the vast majority of cases. Future trends may involve increasing utilization of polymerase chain reaction for diagnosis, and possibly office-based pars plana vitrectomy for treatment of endophthalmitis.

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Microbiologic spectrum and susceptibility of isolates in acute postcataract surgery endophthalmitis: are they same as they were more than a decade ago?

Cited by 20 publications

References 6 publications

Microbiologic spectrum and susceptibility of isolates in delayed post-cataract surgery endophthalmitis

Microbiologic spectrum and susceptibility of isolates in delayed post-cataract surgery endophthalmitis

Redefining evidence in the management of acute post-cataract surgery endophthalmitis in India - The 2014 Adenwalla Oration, All India Ophthalmological Society

Update on the prevention and treatment of endophthalmitis

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