Microbiological and aMMP-8 findings depending on peri-implant disease in patients undergoing supportive implant therapy

Ziebolz, Dirk; Schmalz, Gerhard; Gollasch, Daniel; Eickholz, Peter; Rinke, Sven

doi:10.1016/j.diagmicrobio.2017.02.008

Cited by 25 publications

(29 citation statements)

References 46 publications

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“…However, Wang et al reported that MMP-8 alone was not able to differentiate peri-implantitis patients from healthy patients [ 67 ]. T. denticola and Prevotella intermedia were reported to show diagnostic ability in case of peri-implantitis [ 67 , 72 , 73 ]. Gingival inflammation showed correlation to aMMP-8 levels in PISF [ 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Ramseier et al reported a positive correlation between MMP-8, PI, and BOP in both GCF and PISF [ 65 ]. Ziebolz et al have demonstrated that PISF aMMP-8 levels can be kept successfully low during maintenance in patients undergoing successfully supportive implant therapy indicating that successful professional maintenance intervention is associated with low (<20 ng/ml) PISF aMMP-8 levels similar to the healthy peri-implant status [ 73 , 78 , 79 ]. Similar clinical parameters and MMP-8 levels were obtained with both zirconium and titanium abutments at the end of 1 year.…”

Section: Resultsmentioning

confidence: 99%

“…Thus, elevated levels of aMMP-8 in PISF associate significantly and repeatedly with peri-implant inflammation and bone loss/osteolysis [ 21 – 23 , 30 , 78 ]. Low (<20 ng/ml) in aMMP-8 levels in PISF reflects and indicates healthy and/or successfully treated status peri-implantium ( Figure 1 ) [ 73 , 78 , 79 ]. Pathologically elevated levels of aMMP-8 (>20 ng/ml) can be conveniently detected by a quantitative lateral flow aMMP-8 dip-stick test, i.e., ImplantSafe® ( Figure 1 ) [ 17 , 78 ].…”

Section: Resultsmentioning

confidence: 99%

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Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

Al-Majid

Alassiri

Rathnayake

et al. 2018

International Journal of Dentistry

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Levels of and especially the degree of activation of matrix metalloproteinase (MMP-8) in oral fluids (i.e., saliva, mouth rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) increase to pathologically elevated levels in the periodontal and peri-implant diseases. This study aimed at collecting and collating data from previously published studies and determining whether active MMP-8 (aMMP-8) could serve as a biomarker for the diagnosis and prevention of periodontal and peri-implant diseases. The literature search identified a total of 284 articles. Out of 284 articles, 61 articles were found to be relevant. Data obtained from the selected studies were combined, and it indicated that aMMP-8 in oral fluids exerts the strong potential to serve as a useful adjunctive diagnostic and preventive biotechnological tool in periodontal and peri-implant diseases. aMMP-8 can be used alone or in combination with other proinflammatory and/or microbiological biomarkers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

Al-Majid

Alassiri

Rathnayake

et al. 2018

International Journal of Dentistry

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“…SPT plays a critical role in maintaining the stability of periodontal status from the perspective of bacteria amount, clinical outcomes, and further disease progression (Lang & Tonetti, ; Ramfjord, ). Nevertheless, the concept of preventive maintenance should also be advocated in dental implants in terms of bacterial patterns (Agerbaek, Lang, & Persson, ; Ziebolz, Schmalz, Gollasch, Eickholz, & Rinke, ), cost‐effectiveness (Schwendicke, Tu, & Stolpe, ), biological complications (Berglundh et al, ; Salvi & Zitzmann, ), peri‐implant tissue and SR (Goh & Lim, ), and the long‐term stability of treated peri‐implantitis (Roccuzzo, Layton, Roccuzzo, & Heitz‐Mayfield, ).…”

Section: Introductionmentioning

confidence: 99%

The effect of supportive care in preventing peri‐implant diseases and implant loss: A systematic review and meta‐analysis

Lin

Chen

Pan

et al. 2019

Clinical Oral Implants Res

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Objective: To evaluate the influence of supportive treatment (SPT) during a maintenance period after implant placement on implant survival rate (SR) and incidence of peri-implant diseases. Material and methods: A systemic literature search for studies published up toJune 2018 was conducted by two independent reviewers using Pubmed/MEDLINE, EMBASE, and Cochrane Central databases. Clinical controlled trials (CCT) involved in SPT protocol with more than 1-year follow-up were included. Quantitative metaanalyses were carried out to analyze the risk ratio (RR) of SR, the incidence of peri-implantitis, and peri-implant mucositis between SPT and non-SPT groups. Any potential confounding factors were investigated using meta-regression.Results: Nine CCTs fulfilled the criteria. To evaluate the influence of SPT on SR, periimplantitis, and peri-implant mucositis, six of nine, three of nine, and three of nine articles were included in further meta-analysis, respectively. SPT group significantly showed higher SR (RR: 1.10; p < 0.001), lower prevalence of peri-implantitis (RR: 0.25; p < 0.001) and peri-implant mucositis (RR: 0.57; p < 0.001) than the non-SPT group. Meta-regression of the selected studies failed to find an association between SR, peri-implantitis, and peri-implant mucositis and confounding factors: application of chemical agents and the frequency of SPT.Conclusion: SPT can potentially improve peri-implant health in terms of SR, peri-implantitis, and peri-implant mucositis. Additionally, the correlation in recall interval and adjunctive use of chemical agents during SPT to peri-implant diseases and implant loss could not be found. K E Y W O R D Smaintenance, peri-implantitis, supportive treatment, survival rate, systematic review and meta-analysis | INTRODUC TI ONPeri-implant diseases such as peri-implantitis (PI) have recently gained much attention due to uprising prevalence. Recent consensus has concluded plaque as the main cause of peri-implant mucositis and PI (Berglundh et al., 2018). Similar to the process from gingivitis to periodontitis, peri-implant mucositis was regarded as the precursor for peri-implantitis (Jepsen et al., 2015). It should be noted that in spite of the reversibility of peri-implant mucositis, longer healing time compared to gingivitis was still required for complete disease S U PP O RTI N G I N FO R M ATI O NAdditional supporting information may be found online in the Supporting Information section at the end of the article.How to cite this article: Lin C-Y, Chen Z, Pan W-L, Wang H-L.The effect of supportive care in preventing peri-implant diseases and implant loss: A systematic review and metaanalysis. Clin Oral Impl Res. 2019;30:714-724. https ://doi.

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“…However, in an experiment in mice, the greater severity of the inflammatory and dystrophic process was demonstrated around implants rather than around the teeth which was characteristic for a correspondingly higher concentration of MMP-8 [13]. Interestingly, according to the results of a study of 89 patients with 171 intra-skeletal implants, the level of MMP-8 did not differ with mucositis and peri-implant, in contrast to gingivitis and periodontitis [14].…”

Section: Research Backgroundmentioning

confidence: 96%

Dynamics of markers of bone resorption in oral fluid in patients with generalized parodontitis during its treatment

Lukash¹,

Fastovets²,

Павлов³

2019

bmgt

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One of the promising courses in the clinical dentistry is the use of molecular biological markers in patients with periodontal disease. First of all, this is due to the rising trend in the prevalence and risk factors of the disease, which makes relevant finding effective methods for early detection and preventive treatment. 30 patients diagnosed with generalized periodontitis of the I and II degree of severity were selected for the research. In the experimental groups of patients, an immunoassay was used to determine the marker level of bone marrow metabolism (MMP-8) in the oral fluid, in the dynamics of treatment. During the study, the content of this enzyme was found to be indicative of the transformation of the inflammatory process in the gums into the destruction of the alveolar bone.

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Microbiological and aMMP-8 findings depending on peri-implant disease in patients undergoing supportive implant therapy

Cited by 25 publications

References 46 publications

Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

Matrix Metalloproteinase-8 as an Inflammatory and Prevention Biomarker in Periodontal and Peri-Implant Diseases

The effect of supportive care in preventing peri‐implant diseases and implant loss: A systematic review and meta‐analysis

Dynamics of markers of bone resorption in oral fluid in patients with generalized parodontitis during its treatment

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