Microbiological Aspects of Unique, Rare, and Unusual Fatty Acids Derived from Natural Amides and Their Pharmacological Profile

Abstract

: In the proposed review, the pharmacological profile of unique, rare, and unusual fatty acids derived from natural amides is considered. These amides are produced by various microorganisms, lichens, and fungi. The biological activity of some natural fatty acid amides has been determined by their isolation from natural sources, but the biological activity of fatty acids has not been practically studied. According to QSAR data, the biological activity of fatty acids is shown, which demonstrated strong antifungal, antibacterial, antiviral, antineoplastic, anti-inflammatory activities. Moreover, some fatty acids have shown rare activities such as antidiabetic, anti-infective, anti-eczematic, antimutagenic, and anti-psoriatic activities. For some fatty acids that have pronounced biological properties, 3D graphs are shown that show a graphical representation of unique activities. These data are undoubtedly of both theoretical and practical interest for chemists, pharmacologists, as well as for the pharmaceutical industry, which is engaged in the synthesis of biologically active drugs.

Screening Marine Microbial Metabolites as Promising Inhibitors of Borrelia garinii: A Structural Docking Approach towards Developing Novel Lyme Disease Treatment

“…Korormicin is a metabolite of Pseudoalteromonas sp. [ 63 ] and has also been known to produce reactive oxygen species to kill bacterial species like Vibrio cholerae and Pseudomonas aeruginosa [ 64 ]. 6′-Hydroxypestalotiopsone C is derived from the mangrove-derived endophytic fungus Acremonium strictum [ 65 ], while Pestalotiopsone E is derived from Pestalotiopsis sp.…”

Influence of Nutrient Deprivation on the Antioxidant Capacity and Chemical Profile of Two Diatoms from Genus Chaetoceros

“…In this way, they could influence locomotion, angiogenesis, and sleep in mammals [43]. They have numerous bioactive properties, such as anticancer, antimicrobial, anthelmintic and antidiabetic activities [44][45][46][47]. Oleamide is the most studied PFAA and has promising potential against Alzheimer's disease [43][44][45]48].…”

Coral Lipids

“…The majority of coral polar lipids consist of phospholipids. Components such as DPG (13, see structure in Figure 11), CAEP (14), LPS (15), LPC (16), LPE (17), PI (18), PA (19), PS (20), PC (21), PE (22), plasmalogen PE (23) and cerebroside (CE) have been identified in the polar lipid composition of Vietnamese corals [87,88]. Typically, the phospholipid quantity is derived from the content of inorganic phosphorus.…”

“…The world of corals, along with its varied symbionts, is a rich repository of biologically active secondary metabolites. These compounds, encompassing fatty acids, steroids, triterpenoids, distinct lipids, alkaloids, and low-molecular-weight terpenoids, have captivated the scientific community [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. While it is recognized that corals host an array of symbionts, including microalgae, fungal endophytes, bacteria, and other microorganisms, there remains uncertainty regarding the precise origin of certain compounds-be it the corals or their microbial allies [25][26][27][28][29].…”