Microbiological Aspects on Peritonsillar Abscesses

Flodström, Anders; Hallander, Hans O.

doi:10.3109/inf.1976.8.issue-3.06

Cited by 67 publications

(28 citation statements)

References 6 publications

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“…In our study , 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 11 GAS was isolated in 19% of PTA patients, which is less than reported by some studies [4,10,15] and similar to the findings of other studies [3,8,9,[11][12][13][14].…”

Section: Discussioncontrasting

confidence: 65%

“…Some studies have found quantitative and qualitative differences in bacteriologic culture results after antibiotic treatment [3,6,8,13] while others have not [4][5]. Only Flodström et al [15], in 1976, have studied the microbiologic flora exclusively in PTA patients with no prior antibiotic treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have looked at the bacteriology of PTA aspirates [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. A mixture of aerobic and anaerobic bacteria is commonly isolated.…”

mentioning

confidence: 99%

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Significant pathogens in peritonsillar abscesses

Klug

Henriksen

Fuursted

et al. 2010

Eur J Clin Microbiol Infect Dis

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Purpose: Peritonsillar abscesses (PTA) are polymicrobial infections, with a diverse aerobic and anaerobic flora. The aim of the present study is to compare bacteriologic culture results from patients with PTA to those from patients undergoing elective tonsillectomy (clinically non-infected tonsils), to better elucidate the pathogenic significance of various isolates. Methods: A prospective study was conducted on 36 PTA patients undergoing acute tonsillectomy and on 80 electively tonsillectomized patients. Results: Fusobacterium necrophorum (FN) and Streptococcus Group A (GAS) were isolated significantly more frequently from the tonsillar cores of PTA patients, both from the abscessed (P=0.001 and P=0.046, respectively) and non-abscessed side (P<0.001 and P=0.046, respectively), than from the tonsillar cores of electively tonsillectomized patients. Conclusions:Our findings indicate that FN and GAS are the prominent pathogens in PTA. In patients with PTA the incidence of FN and GAS isolated from the abscessed tonsil was the same as from the non-abscessed contralateral side, and the growth was comparable by a semi-quantitative approach. Our findings suggest that FN is also of pathogenic importance in acute tonsillitis, and that FN growth is not a subsequent phenomenon once an abscess has formed. Our findings further suggest that other factors influence the development of PTA.

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

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Significant pathogens in peritonsillar abscesses

Klug

Henriksen

Fuursted

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…Culture procedures were performed as described elsewhere [5,8], All strains were freeze-dried for later susceptibility testing.…”

Section: Bacteriological Methodsmentioning

confidence: 99%

A Clinical and Bacteriological Evaluation of the Effect of Sulphamethoxazole-Trimethoprim in Acne vulgaris, Resistant to Prior Therapy with Tetracyclines

Nordin¹,

Hallander²,

Fredriksson³

et al. 1978

Dermatology

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42 patients with acne vulgaris, clinically resistant to prior therapy with tetracyclines, were evaluated after therapy with sulphamethoxazole-trimethoprim (400 + 80 mg) twice daily. Initially and after 6, 12 and 18 weeks of treatment in each patient the different acne lesions were counted and pus specimens from unhealed pustules were taken for bacteriological analysis. Complete remission or excellent results were obtained in 33 patients (79%) at the end of treatment despite a relative increase of Staphylococcus hominis and Propionibacterium granulosum. These species were more resistant in agar dilution test to the combination sulphamethoxazole-trimethoprim (20:1) than other isolated species.

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“…In earlier studies (5,7) betastreptococci were isolated from the abscesses in about 50% of cases with acute peritonsillitis, and one or more anaerobic microorganisms were isolated in the remaining cases. In vitro, some of these anaerobes are substantially more susceptible to ampicillin compared with penicillin V (6), which is often used to treat quinsy.…”

mentioning

confidence: 99%

Pharmacological and Clinical Study of Bacampicillin in Acute Peritonsillitis–a Comparison with Ampicillin

Hallander¹,

Flodström²,

Sjövall³

1977

Antimicrob Agents Chemother

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The pharmacological and clinical properties of bacampicillin in three dosage groups were studied in 66 hospitalized patients with unilateral acute peritonsillitis in a comparison with ampicillin. Bacampicillin is a new semisynthetic aminopenicillin which is rapidly converted to ampicillin but is better absorbed. Both drugs were given orally. The mean individual peak serum levels achieved with 200, 400, and 800 mg of bacampicillin in the first morning dose were 4.9, 6.8, and 11.9 mg/liter, respectively, with an almost linear dose response. The peak level of 800 mg of bacampicillin was significantly higher than the 6.8 mg/liter noted after a nearly equimolar dose of 500 mg of ampicillin. A linear relationship was also seen between dose and area under the serum concentration-time curve. Preliminary antibiotic concentration studies in five patients indicated therapeutic levels in peritonsillar pus. Beta-streptococci alone or in combination with anaerobes were isolated from about half ofthe abscesses, whereas anaerobes were isolated from the other half. Treatment was supplemented by surgical procedures in the majority of cases. The clinical effect was good in all treatment groups, with only one relapse. All beta-streptococci were eliminated during therapy. The total number ofgastrointestinal side effects was significantly lower in patients treated with bacampicillin, although the difference in frequency of diarrhea alone was not significant.

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Microbiological Aspects on Peritonsillar Abscesses

Cited by 67 publications

References 6 publications

Significant pathogens in peritonsillar abscesses

Significant pathogens in peritonsillar abscesses

A Clinical and Bacteriological Evaluation of the Effect of Sulphamethoxazole-Trimethoprim in Acne vulgaris, Resistant to Prior Therapy with Tetracyclines

Pharmacological and Clinical Study of Bacampicillin in Acute Peritonsillitis–a Comparison with Ampicillin

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