Microbiological Degradation of Tetracyclines

Meyers, Edward A.; Smith, Dorothy A.

doi:10.1128/jb.84.4.797-802.1962

Cited by 13 publications

(2 citation statements)

References 16 publications

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“…Under soil acidic condition, OTC was epimerized in swine manure and formed degradation products such as 4epi-OT and epi-N-desmethyl-OT [27,35]. Ingerslev et al [36] found that biodegradation of TCs was the main mechanism in sludge by Ascomycetes fungi [37] and Streptomyces species; however, sorption and transformation of TCs commonly occurred in soil [27,32]. Our study confirmed that the transformation and stability of TCs in sediment and soil are dependent on light, temperature, and physiochemical properties of the matrix [38].…”

Section: Antibiotic Concentrations the Concentrations Of Tcsmentioning

confidence: 99%

Monitoring Antibiotic Residues and Corresponding Antibiotic Resistance Genes in an Agroecosystem

Awad

Kim

et al. 2015

Journal of Chemistry

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Antibiotic resistance genes (ARGs) have been commonly reported due to the overuse worldwide of antibiotics. Antibiotic overuse disturbs the environment and threatens public human health. The objective of this study was to measure the residual concentrations of veterinary antibiotics in the tetracycline group (TCs), including tetracycline (TC) and chlortetracycline (CTC), as well as those in the sulfonamide group (SAs), including sulfamethazine (SMT), sulfamethoxazole (SMX), and sulfathiazole (STZ). We also isolated the corresponding ARGs in the agroecosystem. Four sediment samples and two rice paddy soil samples were collected from sites near a swine composting facility along the Naerincheon River in Hongcheon, Korea. High performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was employed with a solid-phase extraction method to measure the concentration of each antibiotic. ARGs were identified by the qualitative polymerase chain-reaction using synthetic primers. SAs and their corresponding ARGs were highly detected in sediment samples whereas TCs were not detected except for sediments sample #1. ARGs for TCs and SAs were detected in rice paddy soils, while ARGs for TCs were only found in sediment #2 and #4. Continuous monitoring of antibiotic residue and its comprehensive impact on the environment is needed to ensure environmental health.

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Section: Antibiotic Concentrations the Concentrations Of Tcsmentioning

confidence: 99%

Monitoring Antibiotic Residues and Corresponding Antibiotic Resistance Genes in an Agroecosystem

Awad

Kim

et al. 2015

Journal of Chemistry

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“…Very few studies have been devoted to this regard. Meyers and Smith (1962) investigated the application of Xylaria digitata, a fungi to degrade tetracycline antibiotics and found out that they were effective. Other investigations involving the use of microbial degradation are reported by Maki et al (2006).…”

Section: Degradation Of Otc In Microcosm and Control Experimentsmentioning

confidence: 99%

Characterization of microbial degradation of oxytetracycline in river water and sediment using reversed phase high performance liquid chromatography

Dzomba¹,

Kugara²,

Zaranyika³

2015

Afr. J. Biotechnol.

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The fate of oxytetracycline (OTC) in river water and sediment and control experiments was investigated. A high-performance liquid chromatography (HPLC) separation and identification method was used to separate, identify and quantify OTC and its major degradation products. Minimum degradation of OTC was observed in control experiments. Non microbial degradation observed up to day 26 contributed slightly above 20% of the degradation in exposed distilled water experiment. Increase in degradation of OTC after day 26 for both the covered and exposed distilled water experiments were attributed to microbial degradation due to contamination through the openings left in the set ups. Microbial degradation was observed in the river water and sediment experiment and two major degradation products were identified: 4-epi-oxytetracycline (4-epi-OTC) and β-apo-oxytetracycline (β-apo-OTC). βapo-OTC was found to be the most stable degradation product as compared to the other main degradation products 4-epi-oxytetracycline (4-epi-OTC) and α-apo-oxytetracycline, (α-apo-OTC). The present results have shown that microbial degradation plays a major role in the removal of OTC in natural environments.

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Über die enzymatische Detoxifikation und den Wirkungsmechanismus von Oxytetracyclin bei Pilzen

Lyr¹

1965

J of Basic Microbiology

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Die für eine Niederdruck‐Glimmentladung in reinem Wasserstoff charakteristischen stehenden Schichten wurden mit Mikrowollenmethoden bei λ = 20 cm Wellenlänge untersucht. Aus der Bedampfung, Verstimmung und Rauschtemperatur eines flachen Resonators, in dessen Achse sich die Entladung befand, wurden die Konzentration der Elektronen, ihre Stoßfrequenz und die Temperatur bestimmt. Die Auswertung erfordert die numerische Lösung einer Integralgleichung 1. Art, deren Kern die Feldverteilungsfunktion des Resonators ist. In Richtung zur Kathode ist die Elektronentemperatur gegenüber der Konzentration um etwa 0,25 Schichtperioden (φ < π/2) verschoben. Die Meßergebnisse gestatten unter Zugrundelegung eines einfachen Modells, die Rolle einzelner in der geschichteten Wasserstoffentladung wirksamer Elementarprozesse einzuschätzen.

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Microbiological Degradation of Tetracyclines

Cited by 13 publications

References 16 publications

Monitoring Antibiotic Residues and Corresponding Antibiotic Resistance Genes in an Agroecosystem

Monitoring Antibiotic Residues and Corresponding Antibiotic Resistance Genes in an Agroecosystem

Characterization of microbial degradation of oxytetracycline in river water and sediment using reversed phase high performance liquid chromatography

Über die enzymatische Detoxifikation und den Wirkungsmechanismus von Oxytetracyclin bei Pilzen

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