Microbiological Evaluation of Octenidine Dihydrochloride Mouth Rinse after 5 Days' Use in Orthodontic Patients

Abstract

Objective: To determine the absolute and relative antibacterial activity of octenidine dihydrochloride (OCT) against total and cariogenic bacteria in saliva samples of patients with fixed orthodontic appliances during 5 days of usage. Materials and Methods: The study group consisted of 5 male and 13 female subjects who were selected from patients in the Clinic of Orthodontics. Each patient was given physiologic saline (PS), chlorhexidine gluconate (CHX), polyvinylpyrrolidone-iodine complex (PVP-I), and OCT every morning for 5 days, each separated by a 2-week interval. Total and cariogenic bacteria in saliva samples of orthodontically treated patients with fixed appliances were collected during 5 days of usage. Unstimulated saliva was collected as a baseline sample. Saliva samples were collected at 15 minutes, and on the second, third, and fifth day after rinsing the mouth with any of the solutions for 30 seconds, and bacterial counts were detected. Results: OCT showed an ultimate reduction of total viable oral bacteria, Lactobacillus species, and Streptococcus mutans in vivo. OCT also had a significantly greater inhibitory effect than 0.2% CHX and 7.5% PVP-I, from the beginning of the study until the fifth day after the orthodontic appliances were bonded (P Ͻ .1). Conclusions: OCT compared favorably with respect to CHX and PVP-I complex in orthodontically treated patients with fixed appliances (P Յ .1). (Angle Orthod. 2009;79:766-772.)

Combined chlorhexidine-sodiumfluoride mouthrinse for orthodontic patients: Clinical and microbiological study

“…Streptococcus mutans and Lactobacilli are known as most closely bacteria associated with dental caries ( 9 - 11 ). Shortly after bonding orthodontic attachments, level of these bacteria in the oral cavity elevates due to plaque accumulation ( 12 , 13 ).…”

“…Shortly after bonding orthodontic attachments, level of these bacteria in the oral cavity elevates due to plaque accumulation ( 12 , 13 ). Reduction of these cariogenic bacteria is an important step to prevent caries ( 11 ). It has been shown that chlorhexidine (CHX) and fluoride mouthrinses have activity against oral pathogens.…”

Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

“…prior to operations, for plaque reduction, in ventilated patients and to eradicate a colonization with MRSA) [1] . OPE as well as octenidine alone were significantly superior to other current oral cavity antiseptics [38][39][40] . OPE showed expressed antimicrobial action in the regime of anti-inflammatory therapy of parodontal diseases [41] .…”

Mouthwashes in the 21st century: a narrative review about active molecules and effectiveness on the periodontal outcomes

“…However, data from in vitro and in vivo studies suggest that mouthrinses containing Octeneidine hydrochloride as an active ingredient had comparable [72] or greater effectiveness than CHX on cariogenic bacteria. [73][74][75] Further, a recent 4-day plaque-regrowth study found that Octeneidine had antibacterial and antiplaque efficacy comparable to CHX. In spite of the promising findings, this molecule has not been widely used which might be due to its bitter taste and also partly due to the lack of evidence from studies with longer follow-up periods.…”