Microbiological Outcomes Associated With Low Leukocyte Counts in Cerebrospinal Fluid

Wald, Mathieu; Merisor, Simona; Zachary, Pierre; Augereau, Olivier; Gravier, Simon; Jaulhac, B.; Briel, D. De; Velay, Aurélie; Gregorowicz, Guillaume; Martinot, M.

doi:10.1093/ofid/ofaa597

Open Forum Infectious Diseases

2020

DOI: 10.1093/ofid/ofaa597

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Microbiological Outcomes Associated With Low Leukocyte Counts in Cerebrospinal Fluid

Mathieu Wald

Simona Merisor

Pierre Zachary

et al.

Abstract: The significance of low leukocyte counts in cerebrospinal fluid (CSF) remains unclear. We performed a 2-year retrospective study to examine microbiological outcomes associated with CSF leukocytes at 6–10/mm3. Of the 178 samples examined, we detected positive results for 11 samples, including 5 cases of tick-borne encephalitis virus infection.

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2024

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The kappa free light chains index is an accurate diagnostic biomarker for paediatric multiple sclerosis

Sarthou,

Chrétien,

Giorgi

et al. 2024

Mult Scler

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Background: Multiple sclerosis (MS) may occur before the age of 18. Differentiation between paediatric MS (PedMS) and other demyelinating syndromes (ODSs) is challenging. In adult with MS, the kappa free light chain (KFLC) index has proven to be a reliable marker of intrathecal Ig synthesis. Objective: To assess the diagnostic value of the KFLC index in a cohort of patients with paediatric-onset, inflammatory disorders of the CNS. Methods: We included 73 patients and divided them into four groups: PedMS ( n = 16), ODS ( n = 17), encephalitis and/or inflammatory epilepsy (EE, n = 15), and controls without inflammatory CNS diseases ( n = 25). The KFLC index was calculated and compared with the results of the oligoclonal bands determination. Results: The KFLC index was higher in the PedMS group (median (interquartile range (IQR)): 150.9 (41.02–310.6)) than in the ODS (3.37 (2.22–8.11)), the EE (5.53 (2.31–25.81)) and the control group (3.41 (2.27–5.08)), respectively. The best KFLC index cut-off for differentiating between patients with PedMS and controls was 6.83 (sensitivity: 100%; specificity: 92%). A KFLC index over 93.77 indicated that the patient is very likely to have PedMS (sensitivity: 68%; specificity: 100%). Conclusion: The KFLC index is a reliable tool for the diagnosis of MS in a paediatric population.

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The kappa free light chains index is an accurate diagnostic biomarker for paediatric multiple sclerosis

Sarthou,

Chrétien,

Giorgi

et al. 2024

Mult Scler

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show abstract

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Microbiological Outcomes Associated With Low Leukocyte Counts in Cerebrospinal Fluid

Cited by 1 publication

References 32 publications

The kappa free light chains index is an accurate diagnostic biomarker for paediatric multiple sclerosis

The kappa free light chains index is an accurate diagnostic biomarker for paediatric multiple sclerosis

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