Microbiological profile of chronic osteomyelitis with special reference to anaerobic osteomyelitis in a tertiary care hospital of coastal Karnataka

Abstract

Chronic osteomyelitis is a relapsing, persistent, low-grade inflammation of bone caused by various infectious agents. The present study, conducted over a two-year period, on specimens received from cases of chronic osteomyelitis was, to determine the frequency of isolation of aerobic and anaerobic bacteria and to analyse their antimicrobial susceptibility pattern. Specimens were processed for Gram stain, aerobic and anaerobic culture, and were identified according to standard techniques. Significant growth was observed in 102/204 specimens, in which aerobic growth was observed in 62 (60.8%) and anaerobic in 40 (39.2%). Resistance to metronidazole and clindamycin was observed in 6.7% and 30% of the anaerobic isolates, respectively. None of these were resistant to meropenem. A significant proportion of anaerobic isolates were found to be resistant to commonly used empirical drugs, such as clindamycin, thus necessitating a need for routine anaerobic susceptibility testing.

Ultrasound evaluation of inflammation in patients with chronic recurrent multifocal osteomyelitis involving the mandible: report of three cases

“…The degree of inflammatory change in CRMO is different in each location, and new lesions can appear in previously resolved sites or in sites with various phases of healing [7] . Although bone biopsy is usually performed to diagnose CRMO, osteosarcoma and chronic bacterial osteomyelitis are important differential diagnoses due to the presence of osteoblasts or the possibility of negative culture from specimens [ 3 , 8 , [10] , [11] , [12] , [13] , [14] , [15] , [16] ]. Therefore, the appropriate timing and location for biopsy can be ascertained via a phase of active inflammation, not chronic.…”

Bacillus Subtilis Revives Conventional Antibiotics Against Staphylococcus Aureus Osteomyelitis

“…Surgical debridement of necrotic bone combined with long-term administration of antibiotics is a traditional therapy to treat chronic osteomyelitis [15]. Several antibiotics are used for management of S. aureus osteomyelitis, such as vancomycin, tobramycin, daptomycin and clindamycin, but the rapid acquisition of resistance to antibiotics by S. aureus is a signi cant problem [16][17][18][19]. Therefore, it is urgent to nd a more effective antibacterial strategy to prevent occurrence and recurrence of bone infections.…”