Microbiological profile of Chronic Suppurative Otitis Media

Natarajan, A.T.; Chand, Pavan; Vishrutha, K

doi:10.7439/ijbr.v5i3.560

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…Out of 200 patients studied, of the patients were of the age group <10 years (35%) followed by 11-20 years (30%). Most common organisms isolated were Pseudomonas aeruginosa (41.5%) followed by Staphylococcus and members of the enterobacteriaceae family [19]. All these studies showed P.aeruginosa as the commonest causative agent for CSOM which is similar to the current study.…”

Section: Pattern Of Organismssupporting

confidence: 90%

Aerobic bacteriology of chronic suppurative otitis media and its antibiotic susceptibility pattern in a tertiary care hospital, Bagalkot

Gopal

Solabannavar

Riyas

2019

Trop J Pathol Microbiol

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Background: Chronic Suppurative Otitis Media (CSOM) remains one of the most common childhood chronic infectious diseases worldwide, affecting diverse racial and cultural groups both in developing and industrialized countries. India is one of the countries with highest CSOM prevalence (>6%) where urgent attention is needed. Infection usually results from bacterial, fungal and in some cases secondary to other viral infections like upper respiratory tract infections and tuberculosis. It is a common cause of conductive deafness which may lead to delayed development of speech and language in children and fatal intracranial complications. Change in the bacteriological scenario with indiscriminate use of antimicrobial agents has been associated with the emergence of multiple drug resistant strains. Therefore, the present study was carried out to determine the aerobic bacteria involved and their antibiotic susceptibility pattern in patients with CSOM. Methods: Ninety-three clinically diagnosed cases of CSOM of all age groups and both the sexes attending ENT OPD and admitted in ENT wards were studied. Two swabs were taken from each patient, one for Gram's staining and the other one for culture onto blood agar and MacConkey agar. After isolation, Gram stain, and biochemical reactions were done according to the procedures. Antibiotic susceptibility testing was done by Kirby-Bauer disc diffusion method. Results: 90.3% of the total samples yielded bacterial growth, while 9.68% were sterile. A total number of 10 different bacterial species were isolated from 89 isolates. The most common organism isolated was P.aeruginosa (30.3%) followed by S. aureus (27%), P. mirablilis (11.2%), K. pneumoniae (9%), E. coli (5.6%), CONS (5.6%), C. freundi (5.6%), Acinetobacter spp (2.2%), S. pyogenes (2.2%) and P.vulgaris (1.1%). Among Gram negative isolates the most sensitive drugs were amikacin and ofloxacin with 93.1% sensitivity, followed by piperacillin + tazobactam (88.9%) and ciprofloxacin (81%). Amoxyclav was the most resistant antibiotic (10.3%). The most effective antibiotic against gram positive bacteria in the present study was found to be ofloxacin and vancomycin (both 100% sensitivity), followed by chloramphenicol (96%). Ampicillin was the most resistant antibiotic, only 19.4% organisms were sensitive to it. Conclusion:The most common organism isolated was P.aeruginosa followed by S. aureus. The most effective antibiotic against gram positive bacteria was found to be ofloxacin. Among gram negative isolates the most sensitive drugs were amikacin and ofloxacin.

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Section: Pattern Of Organismssupporting

confidence: 90%

Aerobic bacteriology of chronic suppurative otitis media and its antibiotic susceptibility pattern in a tertiary care hospital, Bagalkot

Gopal

Solabannavar

Riyas

2019

Trop J Pathol Microbiol

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“…In the present study 17 . The observations made from different studies indicate that there may be variation in causative organism and their antimicrobial sensitivity due to differences on ethnic and geographic fact and also the pattern of use of antibiotics.…”

Section: Resultsmentioning

confidence: 48%

Antimicrobial Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media

Ahmmed

Asaduzzaman

Ahmed

et al. 2020

Bangladesh J of Otorhinolaryngology

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Background: Chronic suppurative otitis media (CSOM) is one of the common diseases of the middle ear especially in developing countries. Early and effective treatment based on the knowledge of causative micro-organisms and their antimicrobial sensitivity pattern ensures prompt clinical recovery and possible complications may be avoided. Objectives: This study was done to determine the pattern of bacterial isolates and to detect their antibiogram. Methods: A total of 103 patients clinically diagnosed of CSOM were enrolled in the study and the samples were obtained from each patient using sterile cotton swabs and cultured for bacterial isolates. Antimicrobial susceptibility test of the isolates were performed using Kirby- Bauer disc diffusion method. Results: Among the cases females were more affected than males. Out of the 103 cases, bacteriological investigation revealed that Pseudomonas aeruginosa 42 (44.68%) and Staphylococcus aureus 31(32.97%) were the predominant bacteria. Ciprofloxacin and Ceftazidime revealed high level of sensitivity whereas high resistance rates were observed for Amoxycillin, Gentamicin and Cephalexin. Conclusion: The study concluded that an appropriate knowledge of the etiological agents and antibacterial susceptibility of microorganisms would contribute to a rational use of antibiotics, success of treatment and reduce the complications of CSOM. Bangladesh J Otorhinolaryngol; October 2016; 22(2): 90-95.

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“…This could be attributed to inadequate diet and nutrition in the age group, which weakens the immune system, damages mucosal tissues, and hinders growth and development in children. 10 Various factors may influence the association between serum levels of vitamins A and E and CSOM with cholesteatoma. Epithelial cell metaplasia is a common occurrence in organs primarily composed of ciliated columnar epithelial cells, such as the eustachian tube.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8] CSOM with cholesteatoma can lead to bone damage in the tympanic cavity, mastoid, and nearby areas, increasing the risk of intratemporal and intracranial complications. 9,10 An imbalance between increased reactive oxygen species (ROS) and antioxidant defence mechanisms triggers oxidative stress, causing cell and tissue damage. This disrupts wound healing process, promoting chronic inflammation that supports the formation of cholesteatoma in CSOM.…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamins A and E Level in Chronic Suppurative Otitis Media with and without Cholesteatoma

Boesoirie,

Hasansulama,

Lasminingrum

et al. 2023

JMDH

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High expression of lytic enzymes and cytokines is related to cell proliferation in Otitis Media Chronic Suppurative (CSOM) with cholesteatoma. In addition, the process of inflammation healing and maintenance of homeostatic conditions requires Reactive Oxygen Species (ROS), which can cause significant damage to cells. To address this issue, secondary antioxidants such as Vitamins A and E are used to inhibit and neutralize the occurrence of oxidation reactions. These vitamins complement each other, with vitamin A working effectively at low concentrations of oxygen, while vitamin E functions in the opposite manner.Purpose: This study aims to investigate the roles of vitamin A and E levels in CSOM patients with Cholesteatoma. Patients and Methods:The study was conducted between July and December 2020, and the method used was an analytical observational approach with a case-control design. The sample population comprised 60 CSOM patients divided into 2 groups. These included those with and without cholesteatoma. Results: The results showed that there was no significant difference between these two groups in terms of the impact of vitamin A and E levels (respectively, p = 0.626, p = 0.864). Conclusion:Considering these results, it was discovered that vitamins A and E levels do not influence the occurrence of CSOM with or without cholesteatoma.

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Microbiological profile of Chronic Suppurative Otitis Media

Cited by 7 publications

References 11 publications

Aerobic bacteriology of chronic suppurative otitis media and its antibiotic susceptibility pattern in a tertiary care hospital, Bagalkot

Aerobic bacteriology of chronic suppurative otitis media and its antibiotic susceptibility pattern in a tertiary care hospital, Bagalkot

Antimicrobial Susceptibility Pattern of Bacterial Isolates from Patients with Chronic Suppurative Otitis Media

The Role of Vitamins A and E Level in Chronic Suppurative Otitis Media with and without Cholesteatoma

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