Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo beta-lactamases and AmpC

Jain, Akash; Jain, Shruti; Ranjan, Priya; Misra, Vaibhav

doi:10.5455/ijmsph.2018.1027919012018

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…Higher incidence of MRSA was detected in Pradeep MSS et al (44.8%) 29 , Patnaik N et al (52.3%) 32 and Jain K et al (48.78%). 33 On the contrary, Aggarwal et al 34 showed incidence of MRSA 10% only and Negi V et al 1 showed it 15.7%. Vancomycin and Linezolid was found to be most effective antimicrobials, irrespective of methicillin resistance.…”

Section: Discussionmentioning

confidence: 96%

Surgical site infection: Clinico- bacteriological Profile and antibiogram in a tertiary care hospital in Kolkata

Sikdar,

Choudhury,

Basu

et al. 2023

PJMS

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Surgical site infections (SSIs) are a major health care associated infections and possess a great challenge to clinicians. It increases duration of hospital stay, associated morbidity and mortality and treatment cost. For prompt and appropriate management, it is necessary to understand the appropriate microbial etiology and its antimicrobial susceptibility pattern. To determine the prevalence of SSI along with its clinico-bacteriological profile and antibiogram and to correlate with the risk factors.A cross-sectional study was conducted in the Department of Microbiology of Nil Ratan Sircar Medical College & Hospital, Kolkata for a period of one year (2020-2021). Post-operative surgical site infections within 30 days after surgery were included in the study. All samples were collected from clinically suspected SSI cases and processed in the lab as per standard laboratory protocol. Vitek®2 compact system (BIOMERIEUX) was used for further identification and antimicrobial susceptibility testing. All Gram negative pathogens resistant to 3rd generation cephalosporins were screened for ESBL and AmpC. Carbapenem resistant isolates were subjected to Carba NP test for carbapenemase production. Out of 6582 surgeries, clinically suspected SSIs were detected in 220 cases. Among these 220 patients, 186 patients were confirmed as SSI in the laboratory, SSI rate being 2.83%. In 62.27% cases, growth was mono-microbial. Growth of gram negative organisms were noted in 58.72% cases and gram positive growth was 38.53%. (57.14%) was the predominant isolates followed by (35.94%). Diabetes mellitus, obesity and using prophylactic antibiotic >2 hours prior to surgery were found to be significantly associated. For gram positive organism, Vancomycin and Linezolid were found to be most susceptible antimicrobials and for gram negative organisms, it was Polymyxin B and Meropenem. Most of the gram negative organisms were ESBL producer (67.97%). Rapidly emerging multi drug resistant organisms are complicating the management of surgical site infection day by day and possessing significant burden to health care system. For implementation of appropriate antimicrobial policy, it is important to identify bacteriological profile and antibiogram in every hospital.

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Section: Discussionmentioning

confidence: 96%

Surgical site infection: Clinico- bacteriological Profile and antibiogram in a tertiary care hospital in Kolkata

Sikdar,

Choudhury,

Basu

et al. 2023

PJMS

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“…This approach helps the surgeons to control surgical site infections by knowing the resistance to antimicrobials (4). Since, Staphylococcus is the most common bacterial organism causing wound infections in hospitals and its incidence ranges from 30-70% in India (5). The importance of the detection of MRSA for treatment and epidemiological purposes is required (6).…”

Section: Introductionmentioning

confidence: 99%

Microbiological and Antimicrobial Resistance profile of isolates from Surgical Site Infections: a study in a Tertiary Care Hospital

Bakshi,

Kaur,

Bansal

et al. 2021

GMCP

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Post-operative wound infections or surgical site infections (SSIs) cause critical healthrelated infections resulting in longer hospital stays, increased healthcare expenses, patient's discomfort and are likely to have an important role in the growth of antimicrobial resistance. Staphylococcus is the most common bacterial organism causing wound infections in hospitals. The present study was done to identify aerobic cultural isolates from post-operative infected wounds and to study the drug susceptibility profile of the bacterial isolates. Staphylococcus aureuswere the most commonly isolated bacteria followed byE. coli, K. pneumonia, Pseudomonas aeruginosa, Proteusmirabilis, and Acinetobacterbaumanii complex. The drug resistance susceptibility profile showed high rate of drug resistance to most commonly used drugs like gentamicin, ciprofloxacin and ceftriaxone.

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Microbiological profile of infection in intensive care unit and their antimicrobial susceptibility pattern with special reference to metallo beta-lactamases and AmpC

Cited by 2 publications

References 12 publications

Surgical site infection: Clinico- bacteriological Profile and antibiogram in a tertiary care hospital in Kolkata

Surgical site infection: Clinico- bacteriological Profile and antibiogram in a tertiary care hospital in Kolkata

Microbiological and Antimicrobial Resistance profile of isolates from Surgical Site Infections: a study in a Tertiary Care Hospital

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