Microbiological profile of infective keratitis in a tertiary care hospital in north Karnataka

Biradar, Sunilkumar S; Nigudgi, Amaresh; Doddamani, Praveen Kumar; Kollur, Pampareddy B.

doi:10.18231/j.ijmr.2021.035

Cited by 1 publication

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“…1 As per reports of the World Health Organization (WHO), major causes of vision loss and blindness in the world today is cataract followed by corneal diseases. [2][3][4][5] According to The National Blindness and Visual Impairment Survey (2015-2019), corneal related diseases are still among the major causes of blindness in India. 6 The patient demographic, corneal health, geographic location, and climate have all been found to affect the aetiology and epidemiological patterns of corneal ulcers, which also tend to change over time.…”

Section: Introductionmentioning

confidence: 99%

Microbiological Profile of Infectious Keratitis at a Tertiary Care Hospital

Chauhan¹,

Kaur²,

Himanshu³

et al. 2023

J. Pure Appl. Microbiol.

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In developing countries, infectious keratitis being the probable cause of preventable blindness, also have a varied epidemiological profile. This study was conducted to know the microbiological profile, risk factors, epidemiology and antimicrobial susceptibility pattern of bacteria isolated from patients with a corneal ulcers. A total of 193 patients who were clinically diagnosed with cases of infective keratitis in the Department of Ophthalmology were included in the study. The sample collected by an ophthalmologist was received in the Microbiology department. All the demographic details and relevant clinical data were noted. The bacterial identification and antimicrobial susceptibility were done using automated methods while the fungal identification was done using the conventional method (Vitek2 Compact system, BioMerieux). Out of 193 patients, 69% were male and 31% % were females. The Majority of cases were from the age group 41- 50 years. Of 193 cases, 83 (43%) showed microbial etiology in culture. Of 83 culture positive cases, 55 (66.3%) were fungal and 28 (33.7%) were bacterial. The most common isolated fungus was Fusarium species detected in 24 (28.9%) cases followed by Aspergillus species in 14 (16.8%) cases. Gram positive bacteria were predominantly isolated from cases of infective keratitis. Staphylococcus aureus was the most common isolated bacteria in 12 (14.4%) out of 83 positive cases followed by Coagulase negative Staphylococcus. Pseudomonas aeruginosa was the most common Gram negative bacteria isolated from the cases. Among the topical antimicrobials, both Gram positive bacteria as well as Gram negative bacteria showed maximum sensitivity to levofloxacin. Proper knowledge of the clinical presentation and etiological agents aided with microbiological examination is necessary in order to effectively treat corneal ulcers and prevent further complications that can lead to blindness.

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