Microbiological substantiation of application of phytopreparations in treatment of inflammatory periodontal diseases

Impairment of immunological reactivity in inflammatory periodontal diseases is well proven. To perform immunomodulatory treatment in domestic dental practice, various medications are used, including natural, chemically modified, recombinant, genetically engineered and synthetic substances, which differ in their effects upon innate and adaptive immune systems. Complex preparations of natural cytokines as well as genetically engineered preparations of IL-1, IL-2, growth factors, IFNα, IFNβ, IFNγ are applied in clinical settings. Clinical implementation of interferon and interferon inducers in combined therapy of generalized periodontitis is shown to increase resistance to viral components of the oral microbiota. Growth factors (platelet growth factor, fibroblast growth factor, endothelial growth factor, etc.) are successfully used for tissue regeneration in periodontics and maxillofacial surgery. Experimental studies have shown that local administration of toll-like receptor-9 and CD40 ligand may reduce periodontal ligature inflammation and bone loss in mice by inducing B-cell proliferation and increasing IL-10 mRNA expression. Promising results in development of new biologically active drugs are obtained with nanotechnology approaches, i.e., production of composite materials of metal nanoparticles with polymers, growth factors, and local application of these products. General limitations of all these growth factors include extremely short periods of biological activity, and adjusted duration of local effective concentrations. Therefore, it is important to develop a drug delivery system using appropriate scaffolding elements thus allowing local effects of the drug for a certain period of time. In experimental models, alginate hydrogels performed well upon local delivery of granulocyte-macrophage colony-stimulating factor and stromal lymphopoietin of the thymus. A new immunomodulatory strategy for alveolar bone regeneration targets macrophages. A biologically functionalized injectable microsphere of heparin-modified gelatin nanofibers that mimic the architecture of the natural bone extracellular matrix, and provide an osteoconductive microenvironment for bone cells includes IL-4, which has heparin-binding domains. These medications represent a component of a comprehensive treatment schedule, and should be evaluated for immune status before and after therapy. Thus, recent advances in studies of innate and acquired immune responses in inflammatory diseases and, in particular, in periodontal disorders, allows us to develop new approaches and methods of treatment in order to improve efficiency of complex therapy in the inflammatory periodontal diseases.

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Current opportunities and prospectives of immunotropic therapy in chronic generalized periodontitis

Antonov

Мудров²,

Nelyubin

et al. 2021

Med. immunol.

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Dynamics of local cytokine status in patients with parotid salivary gland sialadenosis depending on the treatment algorithm

et al. 2022

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Sialadenosis is a dystrophic disease of the salivary glands parenchyma, which leads to secretory disorders and hypertrophy of salivary glands. Sialadenitis develops in cases of secondary inflammation. Standard methods and medications for the treatment of sialadenosis lead to regression of clinical manifestations and remission. Usage of herbal extracts with prolonged action has a long-term local anti-inflammatory effect with minimal side effects, including those affecting oral mucosa. However, their use in the complex treatment of sialadenosis has been scarcely studied. Objective of our investigation was to estimate cytokine status dynamics in saliva from the parotid glands in the patients with sialadenosis and hypothyroidism during complex treatment which included the prolonged-action herbal remedy. 52 patients with sialadenosis of parotid salivary glands and hypothyroidism were divided into 2 groups: in the I group, 26 patients received basic therapy; in the II group, 26 patients received basic therapy + herbal drugs with prolonged effect as resorbable tablets. Control group consisted of 20 conditionally healthy people without disorders of parotid glands and thyroid gland. Comparative evaluation was performed 1 and 6 months after starting the treatment, with respect to clinical findings, sialometry and cytokine profile. The content of interleukins IL-1β, IL-6, IL-10 and tumor necrosis factor (TNF) was determined in saliva of parotid glands by ELISA technique. The 1st group of patients showed exacerbations within six months of basic treatment, and the sialometry data pointed to maintenance of decreased parotid function. In the 2nd group, when using basic treatment + herbal drugs, no clinical features of sialadenosis were evident within 6 months. The sialometry values were normalized, and the secretory function of the parotid glands was found to be increased. Therefore, it exerted an effect upon moisturization of oral mucosal and improvement quality of life in the patients. Regression of IL- 1β, IL-6 and TNF contents, and IL-10 increase in parotid gland secretions was significantly more pronounced at the terms of 1 and 6 months in cases treated with herbal drugs, compared to Group 1, where a conventional protocol was used. Addition of herbal drugs of prolonged action to the standard protocol of sialadenosis treatment is reasonable and effective.

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Investigation of Changes in Physicochemical Properties of Mixed Saliva in Young People Subjected to Liquid Oral Hygiene Products

Ермишина

Elovicova

Ssablina

et al. 2022

Actual Problems in Dentistry

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Subject. Physicochemical properties of mouthwashes developed and produced by Svoboda Company for everyday use and oral hygiene maintenance. Objectives. To study dynamics of qualitative and quantitative physicochemical and organoleptic properties of mixed saliva in young people subjected to using hygiene and prophylactic domestic mouthwashes. Methodology. The study was carried out by Department of Therapeutic Dentistry and Propaedeutics of Dental Disease, by Department of General Chemistry of Ural State Medical University and by Department of Control Systems Modeling of Ural Federal University. The study involved 40 patients from dental student volunteers (male – 15, female – 25), the average age of volunteers was 18.50 ± 1.6 years. The patients were divided into two groups each containing 20 persons. Mouthwash 1 was a common hygiene oral rinse. Mouthwash 2 was a treatment and prophylactic oral rinse, all participants used the mouthwashes during 3 weeks. Results. The use of the reported mouthwashes contributes to increase in cleansing properties of saliva in both groups of subjects. During mouth rinse treatment, the surface tension of saliva increases. The surface tension of mixed saliva is increased by 28.9% (p ≤ 0.05) with Mouthwash 1 and by 9.5 % (p ≤ 0.05) with Mouthwash 2. The surface tension of mixed saliva of subjects of the second group becomes slightly above normal (40-60 erg/cm2; p ≤ 0.05). Conclusion. The study of changes in physicochemical properties of mixed saliva in young people, volunteers of the two groups, subjected to liquid oral hygiene products, mouthwashes, during three weeks showed the following results: the treatment and prophylactic oral rinse (Mouthwash 2 with titanium glycerosolvate aquacomplex and sodium hyaluronate) promotes more adequate maintenance of the acid-base balance in the oral cavity, pH change of mixed saliva toward the alkaline and maintenance of the normal level (p ≤ 0.05) of buffer capacity which reduces the risk of dental caries.

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Microbiological substantiation of application of phytopreparations in treatment of inflammatory periodontal diseases

Cited by 4 publications

References 3 publications

Current opportunities and prospectives of immunotropic therapy in chronic generalized periodontitis

Current opportunities and prospectives of immunotropic therapy in chronic generalized periodontitis

Dynamics of local cytokine status in patients with parotid salivary gland sialadenosis depending on the treatment algorithm

Investigation of Changes in Physicochemical Properties of Mixed Saliva in Young People Subjected to Liquid Oral Hygiene Products

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