Microbiology of Bone and Joint Infections

Ryu, Seong Yeol; Patel, Robin

doi:10.1002/9781118581742.ch2

Cited by 2 publications

(4 citation statements)

References 54 publications

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“…The imaging presentation of spinal TB is highly consistent with other infections and spinal metastatic adenocarcinoma (Xiang et al, 2021). For inflammatory parameters, the elevation in C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) has indications but with relatively low specificity (Ryu and Patel, 2015). As the key element for acid-fast bacilli smear (AFBS) (Golden and Vikram, 2005), MTB culture (Dunn and Ben Husien, 2018), molecular polymerase chain reaction GeneXpert MTB/RIF (Chin et al, 2019), and histological exam (Dunn and Ben Husien, 2018), the tissue from bone biopsy has a higher diagnostic yield than pus.…”

Section: Introductionmentioning

confidence: 88%

“…Tuberculosis (TB) is a kind of bacterial communicable disease caused by the Mycobacterium tuberculosis (MTB) complex (Furin et al, 2019). Spinal TB is a common spine infection disease, usually caused by lymphohematogenous spread from a pulmonary TB and occasionally by genitourinary system TB spread via venous or arterial routes in some cases (Ryu and Patel, 2015;Dunn and Ben Husien, 2018). Spinal TB is prevalent in children and young adults, usually during the initial latent phase of the infection (Ryu and Patel, 2015;Dunn and Ben Husien, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…To date, spinal TB has been diagnosed by several approaches, including imaging, inflammatory parameters, bone biopsies for microbiological studies or histopathological studies, gene amplification, and immunoassay (Ryu and Patel, 2015;Dunn and Ben Husien, 2018). The various diagnostic methods of spinal TB have their advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

“…As the key element for acid-fast bacilli smear (AFBS) (Golden and Vikram, 2005), MTB culture (Dunn and Ben Husien, 2018), molecular polymerase chain reaction GeneXpert MTB/RIF (Chin et al, 2019), and histological exam (Dunn and Ben Husien, 2018), the tissue from bone biopsy has a higher diagnostic yield than pus. Therefore, the biopsy specimen should be as large as possible and include intact pieces of bone, shavings, and necrotic material (Ryu and Patel, 2015). Even so, biopsybased tests are still less likely to yield positive results.…”

Section: Introductionmentioning

confidence: 99%

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Tuberculosis-Specific Antigen/Phytohemagglutinin Ratio Combined With GeneXpert MTB/RIF for Early Diagnosis of Spinal Tuberculosis: A Prospective Cohort Study

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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Spinal tuberculosis (TB), the most common form of musculoskeletal tuberculosis, is an infection-related disease globally, with paraplegia occurring in severe cases. Therefore, identification of spinal TB at an early stage is important for early intervention and eventual therapy. In this study, we conducted a prospective cohort study in routine clinical practice to investigate the diagnosis of different TB tests. A total of 519 patients were recruited based on the radiology of spinal TB. The diagnostic model was computed by regression analysis and was determined by receiver operating characteristic (ROC) curve analysis. Specificity, sensitivity, predictive value, likelihood ratio, and accuracy were also computed and compared. GeneXpert MTB/RIF showed a higher positive rate compared to that in the acid-fast bacilli smear and Mycobacterium culture. The results also showed that the Mycobacterium tuberculosis-specific antigen/phytohemagglutinin ratio in the T-SPOT assay had a good performance in the preoperative diagnosis and prediction of spinal TB. The diagnostic model based on the ratio of tuberculosis-specific antigen/phytohemagglutinin combined with GeneXpert MTB/RIF showed better efficiency for spinal TB diagnosis. In summary, the tuberculosis-specific antigen/phytohemagglutinin ratio combined with GeneXpert MTB/RIF could provide an early diagnosis of spinal TB.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tuberculosis-Specific Antigen/Phytohemagglutinin Ratio Combined With GeneXpert MTB/RIF for Early Diagnosis of Spinal Tuberculosis: A Prospective Cohort Study

Liu

et al. 2022

Front. Cell. Infect. Microbiol.

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Unlocking the Diagnostic Potential: A Systematic Review of Biomarkers in Spinal Tuberculosis

Siahaan,

Ivander,

Tandean

et al. 2024

JCM

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Background/Objectives: Spinal tuberculosis (STB) is frequently misdiagnosed due to the multitude of symptoms it presents with. This review aimed to investigate the biomarkers that have the potential to accurately diagnose spinal TB in its early stages. Methods: A systematic search was conducted across multiple databases, yielding a diverse range of biomarkers categorized into complete blood count parameters, host inflammatory responses, bacterial antigens, and RNA-based markers. This review included studies on spinal tuberculosis patients, including blood serum biomarkers, while exclusion criteria included pediatric cases, cerebrospinal fluid or imaging biomarkers, co-infection with other bacteria, viruses, comorbidities, tumors, immune diseases, HIV infection, metabolic disorders, animal studies, opinion papers, and biomarkers relevant to health problems outside the disease. QUADAS-2 was used as a quality assessment tool for this review. This review identifies several promising biomarkers with significant diagnostic potential. Results: The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), IFN-γ, CXCR3, CXCL9, CXCL10, PSMB9, STAT1, TAP1, and specific miRNA combinations demonstrated noteworthy diagnostic accuracy in distinguishing STB from other spinal pathologies. Additionally, these biomarkers offer insights into disease severity and progression. The review also highlighted the importance of combining multiple biomarkers to enhance diagnostic precision. This comprehensive systematic review underscores the potential of biomarkers to revolutionize the diagnosis of spinal tuberculosis. By integrating these markers into clinical practice, healthcare providers can achieve earlier and more accurate diagnosis, leading to improved patient care and outcomes. Conclusions: The combination of multiple biomarkers, including NLR, PSMB9, STAT1, and specific miRNAs, demonstrates promising diagnostic accuracy.

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Microbiology of Bone and Joint Infections

Cited by 2 publications

References 54 publications

Tuberculosis-Specific Antigen/Phytohemagglutinin Ratio Combined With GeneXpert MTB/RIF for Early Diagnosis of Spinal Tuberculosis: A Prospective Cohort Study

Tuberculosis-Specific Antigen/Phytohemagglutinin Ratio Combined With GeneXpert MTB/RIF for Early Diagnosis of Spinal Tuberculosis: A Prospective Cohort Study

Unlocking the Diagnostic Potential: A Systematic Review of Biomarkers in Spinal Tuberculosis

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