Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia

Ćirković, Ivana; Marković-Denić, Ljiljana; Bajcetic, Milica; Dragovac, Gorana; Đorđević, Zorana; Mioljević, Vesna; Urošević, Danijela; Nikolić, Vladimir; Despotović, Aleksa; Krtinić, Gordana; Rakic, Violeta; Šuljagić, Vesna

doi:10.3390/antibiotics11091161

Cited by 5 publications

(2 citation statements)

References 27 publications

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“…Ovakav profil uzročnika BI delimično doprinosi podatku iz poslednje nacionalne studije i godišnjih izveštaja o zaraznim bolestima koji najviše zabrinjava, a to je veoma visoka stopa antimikrobne rezistencije na dostupne antibiotike (28). Posle Rumunije, Srbija je zemlja sa najvišim tzv.…”

Section: Bolničke Infekcije U Srbijiunclassified

“…Kompozitni indeks opisuje stepen rezistencije najčešćih uzročnika BI na glavne terapijske opcije. Jedan od primera je rezistencija uzročnika BI u Evropi na karbapeneme, koja se kreće između 7,4% (Finska) i 68,9% (Rumunija) (3), dok je u Srbiji rezistencija na karbapeneme detektovana u čak 80,5% slučajeva u poslednjoj studiji prevalencije (28).…”

Section: Bolničke Infekcije U Srbijiunclassified

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Healthcare-associated infections in the intensive care unit

Despotović,

Stevanović,

Milić

2024

Medicinski podmladak

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Healthcare-associated infections pose a significant risk for patients and a tremendous burden on hospitals and healthcare systems. Because they can significantly affect treatment outcomes, rigorous surveillance and prevention strategies are key interventions against their occurrence. With the growing problem of antimicrobial resistance, further aggravated throughout the COVID-19 pandemic, it has become challenging to find viable therapeutic options. This is particularly the case in intensive care units, where pathogens exhibit the highest resistance rates. Surveillance of healthcare-associated infections comprises continuous monitoring of causative agents, infection types, and the degree of antimicrobial resistance. Such data can inform intervention choices aimed at prevention, but they are critical in selecting the right empirical and targeted treatment. Alongside clinical, epidemiological, and microbiological data, economic analyses are an equally important aspect of healthcare-associated infection surveillance. They provide key insights into the financial burden on hospitals that are responsible for effective preventative measures. Serbia is, according to national data, a country with one of the lowest rates of healthcare-associated infections in Europe, but has one of the highest antimicrobial resistance rates in Europe. These findings point to a need for systemic changes, including more rational antibiotic use and education of the general public, but also of healthcare professionals, with the idea of preventing further progression and impact on treatment outcomes.

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Section: Bolničke Infekcije U Srbijiunclassified

Healthcare-associated infections in the intensive care unit

Despotović,

Stevanović,

Milić

2024

Medicinski podmladak

Self Cite

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The emergence of multi-drug-resistant bacteria causing healthcare-associated infections in COVID-19 patients: a retrospective multi-centre study

Gajić¹,

Jovićević²,

Popadić³

et al. 2023

Journal of Hospital Infection

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Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens

2023

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The aim of our investigation is to correlate the wholesale data on antibiotic consumption expressed in daily doses per 1000 inhabitants per day (DID) with the resistance rate of invasive pathogen bacteria from 2017 to 2021. The data on antimicrobial resistance were collected from an analysis of the primary isolates of hospitalized patients. According to the CAESAR manual, the selected pathogens isolated from blood culture and cerebrospinal fluids were tested. The consumption of antibiotics for systematic use showed a statistically significant increasing trend (β = 0.982, p = 0.003) from 21.3 DID in 2017 to 34.5 DID in 2021. The ratio of the utilization of broad-spectrum to narrow-spectrum antibiotics increased by 16% (β = 0.530, p = 0.358). The most consumed antibiotic in 2021 was azithromycin (15% of total consumption), followed by levofloxacin (13%) and cefixime (12%). A statistically positive significant correlation was discovered between the percentage of resistant isolates of K. pneumoniae and consumption of meropenem (r = 0.950; p = 0.013), ertapenem (r = 0.929; p = 0.022), ceftriaxone (r = 0.924; p = 0.025) and levofloxacin (r = 0.983; p = 0.003). Additionally, the percentage of resistant isolates of E. coli and consumption of ertapenem showed significant correlation (r = 0.955; p = 0.011). Significant correlation with consumption of the antibiotics widely used at the community level, such as levofloxacin, and resistance isolated in hospitals indicates that hospital stewardship is unlikely to be effective without a reduction in antibiotic misuse at the community level.

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Microbiology of Healthcare-Associated Infections: Results of a Fourth National Point Prevalence Survey in Serbia

Cited by 5 publications

References 27 publications

Healthcare-associated infections in the intensive care unit

Healthcare-associated infections in the intensive care unit

The emergence of multi-drug-resistant bacteria causing healthcare-associated infections in COVID-19 patients: a retrospective multi-centre study

Impact of Antibiotic Consumption on Antimicrobial Resistance to Invasive Hospital Pathogens

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