Microbiology of wound infection after oral cancer surgery

Belušić-Gobić, Margita; Zubovic, A; Predrijevac, Anamarija; Harmicar, David; Cerović, Robert; Gobic, Silvana Udovic; Zubović, Lorena

doi:10.1016/j.jcms.2020.05.011

“…We also preferred SMI because use of the SDCCD could make the intubation process more sterile. Oral wounds are exposed to microbial flora and bacteria in the oral cavity; therefore, the risk of infection is always inherent [12]. In this case, however, we penetrated the…”

Section: Discussionmentioning

confidence: 98%

A novel technique of submandibular intubation with a camera cable drape: a case report

Yun

¹

,

Rhee

²

,

Park

³

et al. 2020

J Dent Anesth Pain Med

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Submental or submandibular intubation has been reported to cause fewer complications than tracheostomy. However, the risk of infection is always inherent because oral wounds are exposed to microbial flora and bacteria in the oral cavity. A novel technique of submandibular intubation was devised to reduce infection and injury to the soft tissues. We would like to report a novel safe technique that can be performed in patients requiring submental or submandibular intubation. This is the first report of submandibular intubation using a sterile disposable camera cable drape. This novel technique of submandibular intubation is safer, more sterile, easier, and less invasive than conventional submandibular intubation.

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“…Therefore, further research is required to reveal its role in the development and progression of oral cancers. In addition, Acinetobacter baumannii is one of the most common clinical multidrug-resistant bacteria that is frequently isolated in wound infection following surgical intervention for OSCC [64]. However, our study was conducted before the surgical procedure; therefore, higher numbers of Acinetobacter baumannii may have existed before surgery, which might have contributed to its commonly reported isolation following oral cancer surgery.…”

Section: Discussionmentioning

confidence: 98%

Variations in oral microbiome and its predictive functions between tumorous and healthy individuals

Yang

¹

,

He

²

,

Zhou

³

et al. 2022

Journal of Medical Microbiology

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Introduction. The oral cavity is one of the largest reservoirs of microorganisms and many pathogenic bacteria have been shown to be associated with the aetiology of oral cancers. Gap Statement. Owing to the complexity of oral microbial communities and their unclear relationship with oral cancer, identification of specific bacteria which contribute to oral cancer is a key imperative. Aim. To compare and investigate the variations in the composition of the bacterial microbiome and its functions between patients with oral tumorous lesions and healthy subjects. Methodology. Twenty-seven samples from individuals with oral tumours (five oral benign tumours and 22 oral squamous cell carcinomas) and 15 samples from healthy subjects were collected. Genomic DNA was extracted and the V3–V5 region of the 16S rRNA gene was sequenced. Subsequently, bioinformatic assessment was conducted using QIIME2, PICRUSt and linear discriminant analysis effect size analyses (LEfSe). Results. The oral microbiota was composed mainly of the phyla Proteobacteria (31.76 %, 35.00 %), Bacteroidetes (30.13 %, 25.13 %) and Firmicutes (23.92 %, 17.07 %) in tumorous and healthy individuals, respectively. Neisseria , Prevotella , Fusobacterium , Streptococcus , Capnocytophaga , Veillonella , Haemophilus , Prevotella , Porphyromonas and Leptotrichia were the most abundant genera. Alpha diversity in the tumour group was significantly greater than that in the healthy group (P<0.05). Differential analysis of microbes between groups demonstrated a significantly higher number of Neisseria , Veillonella , Streptococcus , Leptotrichia , Lautropia , Sphingopyxis , Sphingobium , Tannerella , Actinomyces and Rothia in healthy controls compared with the tumour group. However, the genera Treponema , Micrococcus , Pseudomonas , Janthinobacterium , Parvimos, Loktanella , Staphylococcus , Acinetobacter , Catonella , Aggregatibacter and Propionibacterium were significantly higher in the tumour group. Pathways related to cancers, cell motility, environmental adaptation, metabolism and signal transduction were enhanced in the tumour group, while functions associated with immune system diseases, replication, repair and translation were significantly enhanced in the healthy group. Conclusion. Variations in the oral microbiota and its functions showed a correlation with oral tumours. The tumour group showed an increased abundance of some multi-drug-resistant and periodontitis-related pathogens. The significantly altered microbiotas may serve as potential biomarkers or inform combination therapy for oral tumours.

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“…Among various types of wounds, wet tissue damage, such as mucosal wounds resulting from surgical incisions, traumatic injuries, or persistent ulcers, is prone to cause infection and prolonged inflammation. The incidence of postoperative infection in patients with oral or oropharyngeal cancer has been reported to be approximately 59% (Belusic-Gobic et al, 2020). With the recognition of pathogens by resident immune cells and the aggregation of granulocytes and mononuclear phagocytes, the release of pro-inflammatory cytokines and removal of cellular debris and microorganisms could be initiated through mechanisms such as the production of reactive oxygen species (ROS) (Kolaczkowska and Kubes, 2013;Feehan and Gilroy, 2019).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings

Hou,

Lin,

Xia

et al. 2024

Front. Mater.

0

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Searching for an antibacterial and anti-inflammatory dressing that can stably adhere to wet tissues remains a momentous clinical challenge, especially in the context of treatment failure due to multi-drug-resistant bacteria. Using a hard template method in combination with an in situ chelating strategy, three-dimensional nitrogen-doped graded porous carbon anchored 1.5–2.5 nm CeO2 quantum dots (CeO2-QDs) were tailor-designed in this study. Using the size effect, CeO2-QDs have a higher percentage of Ce3+ and oxygen vacancies that could amplify their antibacterial effects. Polyethyleneimine/polyacrylic acid (PEA) powder could self-gel and be adhesive due to its strong physical interactions, which make it an ideal carrier for CeO2-QDs. PEA@50 (mg/mL) CeO2-QDs hydrogel and PEA@75 (mg/mL) CeO2-QDs hydrogel with moderate doses of CeO2-QDs show a superior antibacterial effect against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) strains. Furthermore, PEA@50CeO2-QDs hydrogels possess excellent anti-inflammatory capacity through their antioxidant activity, which could promote macrophage M2 phenotype polarization. More importantly, cytotoxicity assays on L929 fibroblasts show that PEA@CeO2-QDs hydrogels have no significant toxicity, and a significant proliferative effect could be observed. Overall, PEA@50CeO2-QDs hydrogels have the potential to become a multifunctional wet tissue dressing with anti-inflammatory and antiseptic properties to promote the healing of infected wounds.

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Microbiology of wound infection after oral cancer surgery

Cited by 11 publications

References 30 publications

A novel technique of submandibular intubation with a camera cable drape: a case report

A novel technique of submandibular intubation with a camera cable drape: a case report

Variations in oral microbiome and its predictive functions between tumorous and healthy individuals

Antibacterial and anti-inflammatory polyethyleneimine/polyacrylic acid hydrogel loaded with CeO2 quantum dots for wet tissue wound dressings

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