Microbiome and Human Malignancies

Saha, Abhik; Robertson, Erle S.

doi:10.1007/978-3-030-04155-7_1

Cited by 2 publications

(1 citation statement)

References 114 publications

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“…Intestinal dysbiosis is a possible actor in chronic inflammation, even in distant tissue sites, such as the skin. Imbalance in gut microbiota induces epithelial changes resulting in increased intestinal inflammation and altered gut permeability, which in susceptible individuals may trigger the development of different chronic disease states such as IBD, obesity, diabetes, multiple sclerosis, atopic dermatitis and cancer, among others 45 – 50 . However, until now, only a few studies have addressed this question in psoriasis 6 , 17 , 26 , 27 , 29 , 34 – 36 , 33 .…”

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index

Dei-Cas

Giliberto

Luce

et al. 2020

Sci Rep

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psoriasis is an immune-mediated skin disorder. imbalance of gut microbial populations has been implicated in many diseases. We aimed to investigate whether there were differences in gut microbiota in psoriasis patients vs non-psoriasis controls and between psoriasis severity groups. 55 psoriasis patients and 27 controls were included. V3-V4 regions of the 16S rRNA gene of fecal samples were analyzed using Illumina MiSeq. Bioinformatic analysis was performed. We found changes in gut microbiome composition depending on their psoriasis status as determined by weighted unifrac (p < 0.05), in particular an increase in Firmicutes and depletion of Bacteroidetes in psoriasis patients. Additionally, the Faecalibacterium and Blautia genus were higher in psoriasis patients while Bacteroides and Paraprevotella in non-psoriasis controls (p < 0.05, LDA score > 2). Moderate-to-severe psoriasis patients had lower biodiversity than mild psoriatic patients (p = 0.049). No differences for beta-diversity were found. We developed a Psoriasis-Microbiota Index (PMI), which discriminated among psoriasis patients and controls with sensitivity: 0.78 and specificity: 0.79. Furthermore, we performed a meta-analysis with published data to validate this index. We demonstrated gut dysbiosis in psoriasis patients, suggesting a role in psoriasis pathophysiology. Furthermore, we developed a PMI with the potential to discriminate between psoriasis patients and controls across different populations, which could be used as a biomarker in the clinical practice. Psoriasis is a chronic, immune-mediated inflammatory skin disease. It ranges in severity from a few scattered red, scaly plaques to involvement of almost the entire body surface 1. Psoriasis is estimated to affect about 2-4% of the population in western countries, causes considerable psychosocial disability and has a major impact on patients' quality of life 2,3. Skin lesions are characterized by angiogenesis, an inflammatory reaction with recruitment of T cells into the skin, hyperproliferation of keratinocytes and altered epidermal differentiation 4. Genetic and environmental factors are implicated in psoriasis, although, the exact etiology of the disease is not fully understood 5,6 .

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Section: Discussionmentioning

confidence: 99%

Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index

Dei-Cas

Giliberto

Luce

et al. 2020

Sci Rep

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Mechanistic Development of Cancers Associated with Processed Meat Products: A Review

Bedale,

Milkowski,

Czuprynski

et al. 2023

Meat and Muscle Biology

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Epidemiological data link processed meat products to various cancers, especially colorectal cancer; however,such evidence cannot prove causation. Clear mechanistic evidence of how these foods promote carcinogenesis strengthens the case for causation. Because the complexity and heterogeneity of processed meats as a food category complicate both epidemiological and mechanistic assessments, the study of carcinogenic mechanisms associated with specific components of such foods is often undertaken. These include components that are intrinsic to meats, those that contaminate meat, and those ingredients that are added to or form in meats during processing. Consumption of processed meats also leads to endogenous production of agents, epigenetic changes, and alterations in the microbiota of the digestive tract; therefore,the potential contributions of these endogenous responses to carcinogenesis are also discussed. This review highlights data that illuminate potential mechanisms by which agents associated with processed meats (including processed poultry) could contribute to carcinogenesis. The potential for personal factors such as overall diet, cooking methods, genetic variation, and inflammation and infection status to influence these carcinogenic mechanisms is also summarized. Because the intended audience of this review includes those who may be less familiar with current general mechanisms of mutagenesis and carcinogenesis, detailed background on these topics is provided.

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Microbiome and Human Malignancies

Cited by 2 publications

References 114 publications

Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index

Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index

Mechanistic Development of Cancers Associated with Processed Meat Products: A Review

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