Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation

Refisch, Alexander; Şen, Zümrüt Duygu; Klassert, Tilman E.; Busch, Anne; Besteher, Bianca; Danyeli, Lena Vera; Helbing, Dario-Lucas; Schulze‐Späte, Ulrike; Stallmach, Andreas; Bauer, Michael; Panagiotou, Gianni; Jacobsen, Ilse D.; Slevogt, Hortense; Walter, Martin

doi:10.1016/j.neuropharm.2023.109568

Cited by 14 publications

(3 citation statements)

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“…In recent decades, accumulating research has shown that the interplay between the brain, gut, and microbiota is implicated in the development of depression [38,[63][64][65]. The vast majority of our understanding of how microbes affect mental function has come from preclinical studies in rodent models [66].…”

Section: Gut-brain Axismentioning

confidence: 99%

“…For example, the risk of suicide is 17 times higher in people with mood disorders than in the general population, and follow-up studies have documented that ten to fifteen percent of patients with major depressive disorder (MDD) die by suicide during the course of the disease [37]. Previous studies have suggested that alterations in the gut microbiome are associated with metabolic disturbances and inflammatory processes in individuals with mood disorders [38]. Since the gut microbiome has a strong influence on immuneinflammatory processes [39,40] and, in particular, on the stress response [41], both of which have also been shown to be altered in people with SB [17], changes in the gut microbiome could, thus, further increase the risk of suicidal behavior.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Zerekidze,

Li,

Refisch

et al. 2024

JCM

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Background: Suicide remains a persistent global health challenge, resisting widespread prevention efforts. According to previous findings, toxoplasmosis is particularly associated with altered decision making, which could lead to risk-taking behavior, thereby increasing the likelihood for suicidal behavior (SB). In addition, discussion about the role of microbiome in psychiatric disorders has emerged lately, which also makes it relevant to investigate its role in the context of SB. Therefore, two systematic reviews are integrated in this paper, and the existing knowledge is comprehensively summarized regarding the association between microbial pathogens and SB. Methods: We conducted a systematic search with keywords including SB and Toxoplasma gondii (Suicid* AND Toxoplasm*) and microbiome (Suicid* AND Microbiome AND Microbiota) throughout PubMed and Scopus to retrieve related studies up to 9 November 2023, identifying 24 eligible records. The subjects of the included studies had to have fulfilled the criteria of an SB disorder as defined by DSM-5, and death cases needed to have been defined as suicide. Results: Most studies reported significant association between toxoplasmosis and SB, suggesting a higher likelihood of SB in the infected population. Regarding the microbiome, only very few studies investigated an association between SB and alterations in the microbiome. Based on six included studies, there were some indications of a link between changes in the microbiome and SB. Conclusion: The cognitive aspects of decision making in T. gondii-infected individuals with SB should be further investigated to unravel the underlying mechanisms. Further sufficiently powered studies are needed to establish a link between SB and alterations in the microbiome.

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Section: Gut-brain Axismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Zerekidze,

Li,

Refisch

et al. 2024

JCM

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been suggested that depressive symptoms may induce a chronic stress response ( 25 ), likely due to the interplay of various factors, including traumatic events in life ( 26 ), a deficiency in social support ( 27 ), and adverse lifestyle habits ( 28 ). This, in turn, may trigger physiological changes, such as fluctuating hormone levels ( 29 ), metabolic dysregulation ( 30 ), and autonomic nervous system imbalance ( 31 ). These changes have the potential to increase the risk of cardiovascular disease ( 32 ), diabetes ( 33 ), and other chronic diseases ( 34 , 35 ), thereby reducing life expectancy and increasing the risk of death.…”

Section: Introductionmentioning

confidence: 99%

Depressive symptoms and all-cause mortality among middle-aged and older people in China and associations with chronic diseases

Zhu,

Wang,

et al. 2024

Front. Public Health

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IntroductionIt remains unclear whether depressive symptoms are associated with increased all-cause mortality and to what extent depressive symptoms are associated with chronic disease and all-cause mortality. The study aims to explore the relationship between depressive symptoms and all-cause mortality, and how depressive symptoms may, in turn, affect all-cause mortality among Chinese middle-aged and older people through chronic diseases.MethodsData were collected from the China Health and Retirement Longitudinal Study (CHARLS). This cohort study involved 13,855 individuals from Wave 1 (2011) to Wave 6 (2020) of the CHARLS, which is a nationally representative survey that collects information from Chinese residents ages 45 and older to explore intrinsic mechanisms between depressive symptoms and all-cause mortality. The Center for Epidemiological Studies Depression Scale (CES-D-10) was validated through the CHARLS. Covariates included socioeconomic variables, living habits, and self-reported history of chronic diseases. Kaplan–Meier curves depicted mortality rates by depressive symptom levels, with Cox proportional hazards regression models estimating the hazard ratios (HRs) of all-cause mortality.ResultsOut of the total 13,855 participants included, the median (Q1, Q3) age was 58.00 (51.00, 63.00) years. Adjusted for all covariates, middle-aged and older adults with depressive symptoms had a higher all-cause mortality rate (HR = 1.20 [95% CI, 1.09–1.33]). An increased rate was observed for 55–64 years old (HR = 1.23 [95% CI, 1.03–1.47]) and more than 65 years old (HR = 1.32 [95% CI, 1.18–1.49]), agricultural Hukou (HR = 1.44, [95% CI, 1.30–1.59]), and nonagricultural workload (HR = 1.81 [95% CI, 1.61–2.03]). Depressive symptoms increased the risks of all-cause mortality among patients with hypertension (HR = 1.19 [95% CI, 1.00–1.40]), diabetes (HR = 1.41[95% CI, 1.02–1.95]), and arthritis (HR = 1.29 [95% CI, 1.09–1.51]).ConclusionDepressive symptoms raise all-cause mortality risk, particularly in those aged 55 and above, rural household registration (agricultural Hukou), nonagricultural workers, and middle-aged and older people with hypertension, diabetes, and arthritis. Our findings through the longitudinal data collected in this study offer valuable insights for interventions targeting depression, such as early detection, integrated chronic disease care management, and healthy lifestyles; and community support for depressive symptoms may help to reduce mortality in middle-aged and older people.

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The microbiome’s influence on obesity: mechanisms and therapeutic potential

Tadese,

Mwangi,

Luo

et al. 2024

Sci. China Life Sci.

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Microbiome and immuno-metabolic dysregulation in patients with major depressive disorder with atypical clinical presentation

Cited by 14 publications

References 239 publications

Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Impact of Toxoplasma gondii and Human Microbiome on Suicidal Behavior: A Systematic Review

Depressive symptoms and all-cause mortality among middle-aged and older people in China and associations with chronic diseases

The microbiome’s influence on obesity: mechanisms and therapeutic potential

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