Microbiome and metabolome integrally reveal the anti-depression effects of Cistanche deserticola polysaccharides from the perspective of gut homeostasis

Liu, Xiaojie; Wu, Xiaoling; Wang, Senyan; Zhao, Ziyu; Chen, Jian; Li, Mengyu; Qin, Xuemei

doi:10.1016/j.ijbiomac.2023.125542

Cited by 13 publications

(3 citation statements)

References 62 publications

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“…These microorganisms possess a gene repertoire that is approximately 150 times larger than the human genome [136]. While there is growing evidence suggesting a link between alterations in the microbiome and depressive disorders [137][138][139][140][141][142][143], it is important to note that currently most findings are correlational, and causative relationships have not been firmly established yet [144]. The exact mechanisms through which the microbiome may influence mental health are unclear, and further research is needed to determine the precise role of the microbiome in depression and other behavioral disorders [145].…”

Section: Gut-brain Axismentioning

confidence: 99%

Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review

Liwinski,

Lang

2023

Nutrients

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Depressive disorders pose significant challenges to global public health, necessitating effective prevention and management strategies. Notably, the occurrence of suicide frequently coincides with depressive episodes. Suicide is as a paramount global health concern that demands efficacious preventive strategies. Current psychiatric approaches heavily rely on pharmacological interventions but have had limited success in addressing the global burden of mental health issues. Suboptimal nutrition, with its impact on the neuroendocrine system, has been implicated in the underlying pathology of depressive disorders. Folate, a group of water-soluble compounds, plays a crucial role in various central nervous system functions. Depressed individuals often exhibit low levels of serum and red blood cell folate. Multiple studies and systematic reviews have investigated the efficacy of folic acid and its derivative, L-methylfolate, which can cross the blood–brain barrier, as stand-alone or adjunct therapies for depression. Although findings have been mixed, the available evidence generally supports the use of these compounds in depressed individuals. Recent studies have established links between the one-carbon cycle, folate–homocysteine balance, immune system function, glutamate excitation via NMDA (N-methyl-D-aspartate) receptors, and gut microbiome eubiosis in mood regulation. These findings provide insights into the complex neurobiological mechanisms underlying the effects of folate and related compounds in depression. Through a comprehensive review of the existing literature, this study aims to advance our understanding of the therapeutic potential of folic acid and related compounds in depression treatment. It also seeks to explore their role in addressing suicidal tendencies and shed light on the neurobiological mechanisms involved, leveraging the latest discoveries in depression research.

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Section: Gut-brain Axismentioning

confidence: 99%

Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review

Liwinski,

Lang

2023

Nutrients

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“…Cistanche deserticola is a traditional and valuable Chinese herbal medicine with high edible value that grows mainly in the desert areas of Northwest China [1]. Cistanche deserticola contains phenylethanol glycosides, polysaccharides, and flavonoids [2][3][4], giving it antiinflammatory and antioxidant functions, improved immunity, and other pharmacological effects [5,6]. In recent years, as individuals' concerns for their health have increased, more products derived from Cistanche cistannii have been developed, such as Cistanche cistannii wine and Cistanche cistannii beverages, and the production of Cistanche cistannii products has increased annually [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Optimization of Chemical Extraction Conditions of Dietary Fiber from Cistanche deserticola Residues and Its Structural Characteristics and Physicochemical and Functional Properties

Sun,

Zhao,

Zhang

et al. 2023

Molecules

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Cistanche deserticola residues are by-products of the industrial production of Cistanche deserticola, which are currently often discarded, resulting in the waste of resources. In order to achieve the efficient utilization of Cistanche deserticola, dietary fiber from Cistanche deserticola residues was extracted chemically and the optimization of the extraction conditions was performed, using the response surface methodology to study the effects of the NaOH concentration, extraction temperature, extraction time, and solid–liquid ratio on the yield of water-soluble dietary fiber (SDF). The structural, physicochemical, and functional properties of the dietary fiber were also investigated. The results showed that the optimal conditions were as follows: NaOH concentration of 3.7%, extraction temperature of 71.7 °C, extraction time of 89.5 min, and solid–liquid ratio of 1:34. The average yield of SDF was 19.56%, which was close to the predicted value of 19.66%. The two dietary fiber types had typical polysaccharide absorption peaks and typical type I cellulose crystal structures, and the surface microstructures of the two dietary fiber types were different, with the surface of SDF being looser and more porous. Both dietary fiber types had good functional properties, with SDF having the strongest water-holding capacity and the strongest adsorption capacity for nitrite, cholesterol, sodium cholate, and glucose, while IDF had a better oil-holding capacity. These results suggest that Cistanche deserticola residues are a good source of dietary fiber and have promising applications in the functional food processing industry.

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“…TCM polysaccharide is an effective polysaccharide extracted from a single Chinese medicine by modern scientific and technological methods. It mainly consists of glucose (Glu), rhamnose (Rha), mannose (Man), galactose (Gal), xylose (Xyl), arabinose (Ara), ribose (Rib), fructose (Fru), sucrose (Suc), fucose (Fuc), and other monosaccharide components (14, 15), which has anti-aging, antitumor, immune regulation and other functions (16)(17)(18)(19). A large number of clinical trials and experimental studies have proved that some TCM polysaccharides (especially those extracted from the TCM with possible anti-tumor effect) have a certain function of regulating tumor immune response, with mild or no toxic and side effects at effective doses.…”

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confidence: 99%

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

Liu,

Wu,

Hao

2024

Front. Immunol.

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Hepatocellular carcinoma (HCC) is a prevalent malignancy, often associated with compromised immune function in affected patients. This can be attributed to the secretion of specific factors by liver cancer cells, which hinder the immune response and lead to a state of immune suppression. Polysaccharides derived from traditional Chinese medicine (TCM) are valuable constituents known for their immunomodulatory properties. This review aims to look into the immunomodulatory effects of TCM polysaccharides on HCC. The immunomodulatory effects of TCM polysaccharides are primarily manifested through the activation of effector T lymphocytes, dendritic cells, NK cells, and macrophages against hepatocellular carcinoma (HCC) both in vivo and in vitro settings. Furthermore, TCM polysaccharides have demonstrated remarkable adjuvant antitumor immunomodulatory effects on HCC in clinical settings. Therefore, the utilization of TCM polysaccharides holds promising potential for the development of novel therapeutic agents or adjuvants with advantageous immunomodulatory properties for HCC.

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Microbiome and metabolome integrally reveal the anti-depression effects of Cistanche deserticola polysaccharides from the perspective of gut homeostasis

Cited by 13 publications

References 62 publications

Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review

Folate and Its Significance in Depressive Disorders and Suicidality: A Comprehensive Narrative Review

Optimization of Chemical Extraction Conditions of Dietary Fiber from Cistanche deserticola Residues and Its Structural Characteristics and Physicochemical and Functional Properties

Antitumor immunostimulatory activity of the traditional Chinese medicine polysaccharide on hepatocellular carcinoma

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