“…The adaptation of cold-adapted microorganisms in cold regions is ascribed to the evolutionary development of diverse physiological mechanisms in sub-zero environments over an extended period, which is believed to hold signicant potential for extensive application prospects. At present, the application of microbial agents is widely, especially compound microbial agents, and the majority of them are thermophilic bacteria, in the aspects of regulate the retting process of ax, 8 aatoxin control and promotion of nodule nitrogen xation, 9 improved the quality of compost, accelerate composting process, 10,11 in situ bioremediation of oil-contaminated soil, etc. However, there still exists a signicant knowledge gap in the growth mechanisms, biodegradation mechanisms, applications, and safety assessments of cold-adapted microorganisms.…”