Microbiome diversity in African American, European American, and Egyptian colorectal cancer patients

Elkholy, Amr; Avuthu, Nagavardhini; Abdalla, Mohammed; Behring, Michael; Bajpai, Prachi; Kim, Hyung‐Gyoon; Header, Doaa; Elwafa, Reham Abo; Saed, Hesham M.; Embaby, Amira M.; El-Nikhely, Nefertiti; Obuya, Sarah; Magdy, Mohamed; Badawy, Ahmed Ashour; Nawwar, Ahmed; Afaq, Farrukh; Rogers, Laura Q.; Bae, Sejong; Shikany, James M.; Bateman, Lori Brand; Fouad, Mona N.; Saleh, Mansoor N.; Samuel, Temesgen; Varambally, Sooryanarayana; Guda, Chittibabu; Arafat, Waleed; Manne, Upender

doi:10.1016/j.heliyon.2023.e18035

Cited by 3 publications

(1 citation statement)

References 48 publications

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“… 68 In this study, although we did not measure P. gingivalis -generated phosphoglycerol dihydroceramides or phosphoethanolamine dihydroceramides after infection of OSCC cells, P. gingivalis infection prevented ceramide-dependent mitophagy in both xenograft-derived human OSCC tumors and allograft-derived murine orthotopic OSCC tumors in response to LCL768 in vivo . Further, our 16S rRNA sequencing data showed an increased presence of Gordonia , 69 Stenotrophomonas , 70 , 71 , 72 , 73 and Herbaspirillum 74 , 75 in P. gingivalis- infected tumors that showed resistance to LCL768-induced mitophagy in in vivo orthotopic OSCC tumors. Whether increased levels of these bacteria in the tumor macroenvironment play any independent or synergistic roles in the modulation of lethal mitophagy in response to LCL768 in OSCC tumors is unknown.…”

Section: Discussionmentioning

confidence: 61%

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

Sheridan,

Chowdhury,

Wellslager

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 61%

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

Sheridan,

Chowdhury,

Wellslager

et al. 2024

iScience

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Beneficial microbiome and diet interplay in early-onset colorectal cancer

Zhou,

Kleis,

Depetris-Chauvin

et al. 2024

EMBO Mol Med

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Although the risk of developing CRC increases with age, approximately 10% of newly diagnosed cases occur in individuals under the age of 50. Significant changes in dietary habits in young adults since industrialization create a favorable microenvironment for colorectal carcinogenesis. We aim here to shed light on the complex interplay between diet and gut microbiome in the pathogenesis and prevention of early-onset CRC (EO-CRC). We provide an overview of dietary risk factors associated with EO-CRC and contrast them with the general trends for CRC. We delve into gut bacteria, fungi, and phages with potential benefits against CRC and discuss the underlying molecular mechanisms. Furthermore, based on recent findings from human studies, we offer insights into how dietary modifications could potentially enhance gut microbiome composition to mitigate CRC risk. All together, we outline the current research landscape in this area and propose directions for future investigations that could pave the way for novel preventive and therapeutic strategies.

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Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer

Song,

Shi,

Wang

2024

Mol Med

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Colorectal cancer is the most common type of cancer in the digestive system and poses a major threat to human health. The gut microbiota has been found to be a key factor influencing the development of colorectal cancer. Extracellular vesicles are important mediators of intercellular communication. Not only do they regulate life activities within the same individual, but they have also been found in recent years to be important mediators of communication between different species, such as the gut microbiota and the host. Their preventive, diagnostic, and therapeutic value in colorectal cancer is being explored. The aim of this review is to provide insights into the complex interactions between host and gut microbiota, particularly those mediated through extracellular vesicles, and how these interactions affect colorectal cancer development. In addition, the potential of extracellular vesicles from various body fluids as biomarkers was evaluated. Finally, we discuss the potential, challenges, and future research directions of extracellular vesicles in their application to colorectal cancer. Overall, extracellular vesicles have great potential for application in medical processes related to colorectal cancer, but their isolation and characterization techniques, intercellular communication mechanisms, and the effectiveness of their clinical application require further research and exploration.

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Microbiome diversity in African American, European American, and Egyptian colorectal cancer patients

Cited by 3 publications

References 48 publications

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

Beneficial microbiome and diet interplay in early-onset colorectal cancer

Deciphering the role of host-gut microbiota crosstalk via diverse sources of extracellular vesicles in colorectal cancer

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