Microbiome impact on metabolism and function of sex, thyroid, growth and parathyroid hormones.

Kunc, Michał; Gabrych, Anna; Witkowski, Jacek M.

doi:10.18388/abp.2015_1093

Cited by 45 publications

(41 citation statements)

References 201 publications

(186 reference statements)

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“…Other drugs should be studied to investigate their effects on the intestinal microbiome. Thyroid hormones, another frequently prescribed class of drugs, may have an impact on the intestinal microbiome, and understanding potential bidirectional relationships between the host endocrine system and gut microbiome is fundamental . Contraceptive agents may also have impact on the intestinal microbiome and should be studied in humans and mouse models .…”

Section: Discussionmentioning

confidence: 99%

Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medications

Bastard

Al‐Ghalith

Grégoire

et al. 2017

Aliment Pharmacol Ther

205

131

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Section: Discussionmentioning

confidence: 99%

Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medications

Bastard

Al‐Ghalith

Grégoire

et al. 2017

Aliment Pharmacol Ther

205

131

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“…Perceived stress induces a chemical response via the hypothalamic–pituitary–adrenal axis in the form of glucocorticoid hormone release (usually cortisol or corticosterone), and it is thought that the bacterial response to such biochemicals results in changes to the gut microbiome [8–12]. The gut microbiota can also produce endocrine molecules including biologically active catecholamines (norepinephrine and dopamine) [13], and the gut microbiota can degrade hormones and change host gene expression, with consequences for reproductive success [14]. Thus, in addition to the well-characterised suite of reproductive and adrenal hormones involved in reproduction, host microbiomes have the potential to affect individual fitness.…”

Section: Introductionmentioning

confidence: 99%

Rare gut microbiota associated with breeding success, hormone metabolites and ovarian cycle phase in the critically endangered eastern black rhino

et al. 2019

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Background Host microbiomes play a role in hormone production and subsequent fertility in humans, but this is less well understood in non-model organisms. This is of particular relevance to species in zoo-based conservation breeding programmes, as relationships between host microbiome composition and reproductive output may allow for the development of microbial augmentation strategies to improve success. Here, we characterise faecal bacterial communities of breeding and non-breeding eastern black rhino ( Diceros bicornis michaeli ) using 16S rRNA gene amplicon sequencing and quantify progestagen and glucocorticoid metabolite concentrations through enzyme immunoassays to identify such relationships. Results We identified significant differences in black rhino gut microbiome composition according to ID, institution, breeding success and ovarian cycle phase. In particular, the gut microbiome during pregnancy and post-parturition was significantly altered. Around a third of bacterial genera showed more than ± 10% correlation with either progestagen and/or glucocorticoid concentration, and in general, microbial genera correlated with both hormones in the same direction. Through a combination of analyses, we identified four genera ( Aerococcaceae , Atopostipes , Carnobacteriaceae and Solobacterium ) that were significantly associated with breeding success, pregnancy and/or post-parturition, and higher faecal progestagen metabolite concentrations. These genera had a lower-than-average relative abundance in the gut microbiome. Conclusion Our results indicate that many members of the gut microbiome of black rhino are associated with hormone production and breeding success, and some members of the rare microbiota appear to be particularly important. Although the directionality of the relationship is unclear, the variation in gut microbiome communities represents a potential biomarker of reproductive health. We identified four genera that were associated with multiple indicators of reproductive output; these could be candidate probiotics to improve the breeding success of black rhino in zoo-based conservation breeding programmes. Further work is required to understand the efficacy and feasibility of this, either directly through microbial augmentation (e.g. probiotics) or indirectly via dietary manipulation or prebiotics. Electronic supplementary material The online version of this article (10.1186/s40168-019-0639-0) contains supplementary material, which is available to authorized users.

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“…Besides the fact that human microbes encounter environmental agents via inhaled, oral, or dermal routes before our own mammalian cells, the microbes also respond to external agents. This impacts the status of the microbiome, which in turn affects the host brain and neurological system (Dinan and Cryan 2016), gut (Imhann et al 2016), liver (Selwyn et al 2016), bone (Hernandez et al 2016), kidney (Pluznick 2016), endocrine organs and tissues (Kunc et al 2016), reproductive system (Nelson et al 2016), and immune system and host defense (Levy et al 2016;Brown and Clark 2017). Figure 1.…”

Section: The Human Superorganismmentioning

confidence: 99%

Safety and risk assessment for the human superorganism

Dietert

2017

Human and Ecological Risk Assessment: An International Journal

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This editorial on safety evaluation and risk assessment for the human superorganism introduces a series of papers arguing for a fundamental shift in how we approach human health risk assessment. In this series emphasis is placed on the risk of infectious disease. Our 21 st st century understanding of human biology is that, as holobionts, we possess a majority of microbial cells and genes. In fact, our microbes fundamentally affect our interactions with the external environment, metabolism, physiology, and risk of both pathology and disease. As holobionts, we require our microbial partners for us to be both complete and healthy. Using the 20 th century understanding of human biology, we failed to capture the effects of the microbiome in evaluating health risks. But 21 st century risk assessments such as those associated with exposure to specific microbial pathogens need to include the human microbiome. Microbiome status will be central in determining the health risks for both individuals and populations.

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Microbiome impact on metabolism and function of sex, thyroid, growth and parathyroid hormones.

Cited by 45 publications

References 201 publications

Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medications

Systematic review: human gut dysbiosis induced by non‐antibiotic prescription medications

Rare gut microbiota associated with breeding success, hormone metabolites and ovarian cycle phase in the critically endangered eastern black rhino

Safety and risk assessment for the human superorganism

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