Microbiome in Human Gastrointestinal Cancers

Coker, Olabisi Oluwabukola; Yu, Jun

doi:10.1007/978-3-030-67951-4_2

Cited by 2 publications

(3 citation statements)

References 206 publications

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“…Gut bacteria, fungi, virus, and archaea reportedly play important roles in the gut. These functions, among others, include food digestion, production of essential vitamins, absorption of nutrients, immune modulation, and resistance of colonization by pathogenic microbes [88] . Microbiome (including specific microbes, signaling pathways, and microbiota-related metabolites) contributes to the risk of CRC [67] .…”

Section: Bacterial Infection and Altered Intestinal Microbiomementioning

confidence: 99%

“…Microbiome (including specific microbes, signaling pathways, and microbiota-related metabolites) contributes to the risk of CRC [67] . Changes in the intestinal microbiome can mediate or modify the effects of environmental factors on the risk of CRC (summarized in recent reviews [88,89] ). Briefly, compositional alterations of stool and mucosal microbiomes across stages of colorectal tumorigenesis are characterized by ectopic overgrowth of oral pathogens and depletion of multiple commensal species [66,67,90] .…”

Section: Bacterial Infection and Altered Intestinal Microbiomementioning

confidence: 99%

“…These functions, among others, include food digestion, production of essential vitamins, absorption of nutrients, immune modulation, and resistance of colonization by pathogenic microbes. [88] Microbiome (including specific microbes, signaling pathways, and microbiota-related metabolites) contributes to the risk of CRC. [67] Changes in the intestinal microbiome can mediate or modify the effects of environmental factors on the risk of CRC (summarized in recent reviews [88,89] ).…”

Section: Bacterial Infection and Altered Intestinal Microbiomementioning

confidence: 99%

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Impact of bacterial infection and intestinal microbiome on colorectal cancer development

Sun

2022

Chinese Medical Journal

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Accumulating evidence suggests that intestinal bacteria play an important role in the pathogenesis of colorectal cancer (CRC). Due to the complexity of the intestinal microbiome, identification of the specific causative microbial agents in CRC remains challenging, and the search for the causative microbial agents is intense. However, whether bacteria or their products can induce inflammation that results in tumorigenesis or directly causes CRC in humans is still not clear. This review will mainly focus on the progress of bacterial infection and CRC, and introduce the microbial contribution to the hallmarks of cancer. This article uses Salmonella and its chronic infection as an example to investigate a single pathogen and its role in the development of CRC, based on laboratory and epidemiological evidence. The bacterial infection leads to an altered intestinal microbiome. The review also discusses the dysfunction of the microbiome and the mechanism of host–microbial interactions, for example, bacterial virulence factors, key signaling pathways in the host, and microbial post-translational modifications in the tumorigenesis. Colonic carcinogenesis involves a progressive accumulation of mutations in a genetically susceptible host leading to cellular autonomy. Moving forward, more human data are needed to confirm the direct roles of bacterial infection in CRC development. Insights into the inhibiting infection will help to prevent cancer and develop strategies to restore the balance between host and microorganisms.

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Section: Bacterial Infection and Altered Intestinal Microbiomementioning

confidence: 99%

Section: Bacterial Infection and Altered Intestinal Microbiomementioning

confidence: 99%

Section: Bacterial Infection and Altered Intestinal Microbiomementioning

confidence: 99%

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Impact of bacterial infection and intestinal microbiome on colorectal cancer development

Sun

2022

Chinese Medical Journal

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Microbiome in Colonic Carcinogenesis

Sun

Xia

2023

Comprehensive Physiology

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Microbiomes include bacteria, viruses, fungi, and other microbes. The microbiome modulates numerous aspects of host physiology and is critical in the pathophysiology of diseases, including colon cancer. Although gut bacterial pathogenesis has become an emerging area in colon cancer, the multi-kingdom aspect of microbiome has yet to be explored. Similar to the bacterial component of the microbiome, the virome contains certain makeup that varies between individuals. In the current review, we introduce the concepts of microbiome and microbiota, research history, methods for modern microbiome studies, and recent progress of mechanisms responsible for microbiome and virome in colon cancer. Furthermore, we discuss our understanding of microbial metabolites in the disease development and therapy of colon cancer. Finally, the gut microbiota can affect the efficacy and toxicity of cancer therapy. We discuss the challenges and future perspectives in microbiome and colon cancer. Exploring and understanding the mechanisms of microbiome will provide insights into effective approaches in potential prevention of treatment of colon cancer.

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Microbiome in Human Gastrointestinal Cancers

Cited by 2 publications

References 206 publications

Impact of bacterial infection and intestinal microbiome on colorectal cancer development

Impact of bacterial infection and intestinal microbiome on colorectal cancer development

Microbiome in Colonic Carcinogenesis

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