Microbiota and cancer: host cellular mechanisms activated by gut microbial metabolites

Tsvetikova, Sofia A.; Koshel, Elena I.

doi:10.1016/j.ijmm.2020.151425

Cited by 58 publications

(49 citation statements)

References 184 publications

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“…In addition, the bacteria-induced oncogenesis could also be direct through the effect of microbial metabolites or toxins. Previous studies have shown that several strains of gut microbiota are responsible for the tumorigenesis of different cancer types, such as gastric cancer, colorectal cancer (CRC) and hepatocellular carcinoma (15,16). Their carcinogenic processes are all linked to the production of microbial metabolites.…”

Section: The Impact Of Gut Microbiota On Oncogenesis and Tumor Progressionmentioning

confidence: 99%

“…On the other hand, B. fragilis toxin (Bft) can up-regulate spermine oxidase (SMO) in colon epithelial cells, causing reactive oxygen species (ROS) production and indirect DNA damage (18,19). Other microbial metabolites associated with carcinogenesis include Pasteurella multocida toxin, cytolethal distending Toxin (CDT) (15) and inositol phosphate phosphatase D (IpgD) (16). These could all contribute to the cell transformation, in which the normal cell responses are altered, and further elevate the risk for developing cancer.…”

Section: The Impact Of Gut Microbiota On Oncogenesis and Tumor Progressionmentioning

confidence: 99%

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Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy

Deng

Chen

2021

Front. Oncol.

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In the recent decade, gut microbiota has received growing interest due to its role in human health and disease. On the one hand, by utilizing the signaling pathways of the host and interacting with the immune system, the gut microbiota is able to maintain the homeostasis in human body. This important role is mainly modulated by the composition of microbiota, as a normal microbiota composition is responsible for maintaining the homeostasis of human body, while an altered microbiota profile could contribute to several pathogenic conditions and may further lead to oncogenesis and tumor progression. Moreover, recent insights have especially focused on the important role of gut microbiota in current anticancer therapies, including chemotherapy, radiotherapy, immunotherapy and surgery. Research findings have indicated a bidirectional interplay between gut microbiota and these therapeutic methods, in which the implementation of different therapeutic methods could lead to different alterations in gut microbiota, and the presence of gut microbiota could in turn contribute to different therapeutic responses. As a result, manipulating the gut microbiota to reduce the therapy-induced toxicity may provide an adjuvant therapy to achieve a better therapeutic outcome. Given the complex role of gut microbiota in cancer treatment, this review summarizes the interactions between gut microbiota and anticancer therapies, and demonstrates the current strategies for reshaping gut microbiota community, aiming to provide possibilities for finding an alternative approach to lower the damage and improve the efficacy of cancer therapy.

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Section: The Impact Of Gut Microbiota On Oncogenesis and Tumor Progressionmentioning

confidence: 99%

Section: The Impact Of Gut Microbiota On Oncogenesis and Tumor Progressionmentioning

confidence: 99%

Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy

Deng

Chen

2021

Front. Oncol.

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“…Understanding the role of the microbiome within a specific type of tumor requires study of the combined local and long‐distant effects. The systemic effects of metabolites and small molecules produced by the gut microbiota on cancer have been the topic of many excellent reviews [74–76]. Instead, we will explore the local effects of the organ‐specific microbiome on carcinogenesis, with a focus on the bacterial populations.…”

Section: Intratumoral Microbiota a New Component Of The Tumor Microenvironment (Tme)mentioning

confidence: 99%

The microbiome(s) and cancer: know thy neighbor(s)

González-Sánchez

DeNicola

2021

The Journal of Pathology

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The human microbiome is essential for the correct functioning of many host physiological processes, including metabolic regulation and immune responses. Increasing evidence indicates that the microbiome may also influence cancer development, progression, and the response to therapy. Although most studies have focused on the effect of the gut microbiome, many other organs such as the skin, vagina, and lungs harbor their own microbiomes that are different from the gut. Tumor development has been associated with dysbiosis not only in the gut but also in the tissue from which the tumor originated. Furthermore, the intratumoral microbiota has a distinct signature in each tumor type. Here, we review the mechanisms by which the organ‐specific microbiome can contribute to carcinogenesis: release of toxins that cause DNA damage and barrier failure; alteration of immune responses to create a local inflammatory or immunosuppressive environment; and regulation of nutrient levels in the tumor microenvironment through metabolite production and consumption. Solving the puzzle of how the microbiome influences the carcinogenesis process and treatment response requires an understanding of the two ways the microbiome can interact with cancer cells and the tumor microenvironment: through systemic effects exerted by the gut microbiota and local effects of the intratumoral microbiota. © 2021 The Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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“… 34 , 54 , 55 In addition, short-chain fatty acids (SCFAs), representing a major class of metabolites produced by the metabolism of non-digestible carbohydrates, 11 might confer strong anti-inflammatory profiles via specific G protein–coupled receptors to promote homeostasis of the intestinal epithelium, 56 which play a crucial role in anti-carcinogenesis via exerting extracellular and intracellular effects, and the potential relationships between SCFAs and lymphomagenesis described below. 57 …”

Section: Postulated Molecular Mechanisms For Gut Microbiota–mediated Lymphomamentioning

confidence: 99%

Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms

Shi

Zhang

2021

Clin Med Insights Oncol

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Lymphoid neoplasms encompass a heterogeneous group of malignancies with a predilection for immunocompromised individuals, and the disease burden of lymphoid neoplasms has been rising globally over the last decade. At the same time, mounting studies delineated a crucial role of the gut microbiome in the aetiopathogenesis of various diseases. Orchestrated interactions between myriad microorganisms and the gastrointestinal mucosa establish a defensive barrier for a range of physiological processes, especially immunity and metabolism. These findings provide new perspectives to harness our knowledge of the gut microbiota for preclinical and clinical studies of lymphoma. Here, we review recent findings that support a role for the gut microbiota in the development of lymphoid neoplasms and pinpoint relevant molecular mechanisms. Accordingly, we propose the microbiota-gut-lymphoma axis as a promising target for clinical translation, including auxiliary diagnosis, novel prevention and treatment strategies, and predicting clinical outcomes and treatment-related adverse effects of the disease in the future. This review will reveal a fascinating avenue of research in the microbiota-mediated lymphoma field.

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Microbiota and cancer: host cellular mechanisms activated by gut microbial metabolites

Cited by 58 publications

References 184 publications

Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy

Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy

The microbiome(s) and cancer: know thy neighbor(s)

Emerging Roles for the Gut Microbiome in Lymphoid Neoplasms

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