Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients

Leyrolle, Quentin; Cserjési, Renáta; Demeure, Roger; Neyrinck, Audrey M.; Amadieu, Camille; Rodriguez, Julie; Kärkkäinen, Olli; Hanhineva, Kati; Paquot, Nicolas; Cnop, Miriam; Cani, Patrice D.; Thissen, Jean‐Paul; Bindels, Laure B.; Klein, Olivier; Luminet, Olivier; Delzenne, Nathalie M.

doi:10.3390/nu14010147

Cited by 7 publications

(5 citation statements)

References 60 publications

(75 reference statements)

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“…Furthermore, we have shown that the abundance of Sutterella , a genus from Proteobacteria , is extremely low in CD patients. Sutterella has been described to decrease in individuals with depression as well as in obese patients with mood disorders ( 38 , 39 ). To elucidate if the gut-brain axis is impaired in CD patients and could contribute to the well-known persistence of neuropsychiatric morbidity in them should represent an important goal of future research ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk

et al. 2023

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BackgroundPatients with Cushing’s disease (CD) in remission maintain an increased cardiovascular risk. Impaired characteristics of gut microbiome (dysbiosis) have been associated with several cardiometabolic risk factors.MethodsTwenty-eight female non-diabetic patients with CD in remission with a mean ± SD) age of 51 ± 9 years, mean ( ± SD) BMI, 26 ± 4, median (IQR) duration of remission, 11(4) years and 24 gender-, age, BMI–matched controls were included. The V4 region of the bacterial 16S rDNA was PCR amplified and sequenced to analyse microbial alpha diversity (Chao 1 index, observed number of species, Shannon index) and beta diversity analysis through the Principal Coordinates Analysis (PCoA) of weighted and unweighted UniFrac distances. Inter-group difference in microbiome composition was analysed using MaAsLin2.ResultsThe Chao 1 index was lower in CD as compared with controls (Kruskal-Wallis test, q = 0.002), indicating lower microbial richness in the former. Beta diversity analysis showed that faecal samples from CS patients clustered together and separated from the controls (Adonis test, p<0.05). Collinsella, a genus form of the Actinobacteria phylum was present in CD patients only, whereas Sutterella, a genus from Proteobacteria phylum, was scarcely detectable/undetectable in CD patients as well as Lachnospira, a genus of the Lachnospiraceae family of the Firmicutes phylum. In CS, the Chao 1 index was associated with fibrinogen levels and inversely correlated with both triglyceride concentrations and the HOMA-IR index (p<0.05).ConclusionsPatients with CS in remission have gut microbial dysbiosis which may be one of the mechanisms whereby cardiometabolic dysfunctions persist after “cure”.

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Section: Discussionmentioning

confidence: 99%

Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk

et al. 2023

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“…Affectivity was assessed using the PANAS questionnaire, which is sensitive to changes over time, and is intended to measure mood through positive and negative affectivity. The PANAS is validated in French and has been used in pregnant women [ 21 – 24 ].…”

Section: Methodsmentioning

confidence: 99%

Factors influencing participation and regular attendance in a program combining physical activity and nutritional advice for overweight and obese pregnant women

Lelorain,

Deruelle,

Béhal

et al. 2024

BMC Pregnancy Childbirth

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Background Educational programs incorporating physical activity (PA) sessions and nutritional workshops have demonstrated potential benefits for overweight and obese pregnant women. However, participation in such programs remains challenging. This prospective study aimed to investigate the factors influencing participation and regular attendance, while examining changes in health behaviors, along with obstetric and neonatal outcomes. Methods Pregnant women with at 12–22 weeks’ gestation a BMI ≥ 25 kg/m2 were invited to join an educational program combining three nutritional workshops conducted in groups and 12 weekly PA sessions. They self-selected their participation into the program. Regardless of program uptake and regularity of attendance, the women’s PA levels, eating behaviors, and affectivity were assessed using validated questionnaires at 20–24 weeks, 32–34 weeks, and postpartum. A multivariable logistic regression model was used to determine the factors influencing participation. Results Of the 187 women enrolled in the study, 61.5% agreed to participate in the program. Of these, only 45% attended six or more sessions (regardless of the nature of sessions, i.e. nutritional workshops and/or PA sessions), while only 8.7% attended six or more PA sessions. Participation was associated with higher rates of problematic eating behaviors and lower PA levels at baseline, while regular attendance was mainly associated with higher household incomes. No significant difference was observed between participants and non-participants in terms of changes in eating behaviors, PA levels, or affectivity. However, at the 32–34 week visit, regular participants displayed a higher change in positive affectivity, but unexpectedly also in cognitive restraint, than non-regular participants, a difference that did not persist at postpartum. Conclusion The educational program combining nutrition and PA was shown to be safe. Women facing challenges related to health behavior displayed a willingness to sign up for the program, but tailored interventions addressing their individual challenges are needed to improve attendance. Accordingly, four recommendations are proposed for the design of future interventions. Trial registration ClinicalTrials.gov; Identifier: NCT02701426; date of first registration: 08/03/2016.

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“… 812 Changes in the levels of several amino acid derived metabolites in a cohort of obese patients, such as the decrease of phenylacetylglutamine and the increase of L-histidine, linked to changes in the gut microbiota composition and function. 813 Particularly, P. pentosaceus and L. lactis can ameliorate NAFLD progression by regulating tryptophan metabolism of the gut-liver axis and also closed associated with metabolic dysregulations of bile acid and indole. 814 A study analyzed the correlation between serum metabolites and gut microbiota in elderly patients with chronic heart failure insights into metabolic phenotypes.…”

Section: Metabolic Homeostasis and Gut Microbiotamentioning

confidence: 99%

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu

Cai

et al. 2023

Sig Transduct Target Ther

240

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Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

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Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients

Cited by 7 publications

References 60 publications

Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk

Gut microbial dysbiosis in patients with Cushing’s disease in long-term remission. Relationship with cardiometabolic risk

Factors influencing participation and regular attendance in a program combining physical activity and nutritional advice for overweight and obese pregnant women

Small molecule metabolites: discovery of biomarkers and therapeutic targets

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