Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes

Lacerda, Rodrigo Rodrigues e; Fang, Han; Robin, Nathaniel H.; Bhatwa, Arshpreet; Markó, Daniel; Schertzer, Jonathan D.

doi:10.1016/j.bj.2023.100610

Cited by 8 publications

(2 citation statements)

References 102 publications

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“…NLR family pyrin domain containing (NLRP) inflammasomes generate divergent metabolic responses, with obesity fostering conditions that favor the activation of pro-inflammatory reactions mediated by NLRP3. The team proposes the incorporation of short-acting postbiotics as means to engage protective adaptive immune responses, and facilitate sustained enhancements in blood glucose management [ 20 ].…”

Section: Also In This Issuementioning

confidence: 99%

He protec but he also attac – Inflammasomes swinging the sword

Kattner

2023

Biomedical Journal

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Section: Also In This Issuementioning

confidence: 99%

He protec but he also attac – Inflammasomes swinging the sword

Kattner

2023

Biomedical Journal

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“…Additionally, some variables have been associated with low‐grade systemic and adipose tissue inflammation. These variables include altered adipose tissue resident immune cell phenotype, 3 increased pro‐inflammatory cytokine production and endoplasmic reticulum stress, 4 hypoxia, an increase in reactive oxygen species (ROS), excessive apoptosis, 5 and increased lipopolysaccharide (LPS) levels 6 . In response to a high‐fat diet, intestinal Gram‐negative bacteria upregulate the production of LPS, which can potentially exacerbate inflammation, contributing to a more severe inflammatory response 7,8 .…”

Section: Introductionmentioning

confidence: 99%

The effect of quercetin on adipogenesis, lipolysis, and apoptosis in 3T3‐L1 adipocytes: The role of SIRT1 pathways

Maleki,

Abdizadeh Javazm,

Dastghaib

et al. 2024

Obesity Science & Practice

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BackgroundLipotoxicity, caused by adipocyte triglyceride over‐accumulation, contributes to obesity‐related comorbidities such as hypertension, type 2 diabetes, coronary heart disease, respiratory dysfunction, and osteoarthritis. This study focuses on determining how sirtuin‐1 (SIRT‐1) mediates quercetin's (QCT) effect on 3T3‐L1 adipocytes. Key aspects of this study include preventing adipogenesis, inducing lipolysis, and stimulating adipocyte apoptosis.Methods3T3‐L1 adipocytes underwent treatment with varying QCT doses, lipopolysaccharide (LPS), and the SIRT‐1 inhibitor EX‐527, followed by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide [MTT] assay for cell viability assessment. Furthermore, quantitative real‐time polymerase chain reaction measured mRNA expression levels of adipogenesis markers (fatty acid synthase [FASN] and peroxisome proliferator‐activated receptor gamma [PPARγ]), lipolysis markers (adipose triglyceride lipase [ATGL] and hormone‐sensitive lipase [HSL]), and apoptosis markers (B‐cell lymphoma2 [Bcl‐2], Bcl‐2 Associated ‐X‐protein [BAX] and Caspase‐3).ResultsThe data showed that LPS + QCT significantly reduced cell viability in a dose‐ and time‐dependent manner, unaffected by LPS + QCT + EX‐527. Treatment with LPS + QCT did not affect FASN and PPARγ expression but significantly increased ATGL and HSL mRNA expression compared with LPS alone. Interestingly, EX‐527 reversed the effects of LPS + QCT on lipogenesis and lipolysis markers completely. QCT enhanced apoptosis in a SIRT‐1 independent pattern.ConclusionThe data suggest that QCT suppresses adipogenesis while increasing lipolysis via SIRT‐1. However, QCT's effects on apoptosis appear to be independent of SIRT‐1. These findings provide further evidence for QCT's effects on adipocytes, particularly its interaction with SIRT‐1.

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Evolutionary edge: NOD-like receptors in immunity

Kattner

2024

Biomedical Journal

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Microbiota and Nod-like receptors balance inflammation and metabolism during obesity and diabetes

Cited by 8 publications

References 102 publications

He protec but he also attac – Inflammasomes swinging the sword

He protec but he also attac – Inflammasomes swinging the sword

The effect of quercetin on adipogenesis, lipolysis, and apoptosis in 3T3‐L1 adipocytes: The role of SIRT1 pathways

Evolutionary edge: NOD-like receptors in immunity

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