2022
DOI: 10.1101/2022.02.14.480453
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Microbiota-derived aspartate drives pathogenic Enterobacteriaceae expansion in the inflamed gut

Abstract: SUMMARYInflammation boosts the availability of electron acceptors in the intestinal lumen creating a favorable niche for pathogenic Enterobacteriaceae. However, the mechanisms linking intestinal inflammation-mediated changes in luminal metabolites and pathogen expansion remain unclear. Here, we show that mucosal inflammation induced by Salmonella enterica serovar Typhimurium (S. Tm) infection and chemical colitis results in increased intestinal levels of the amino acid aspartate. The S. Tm and E. coli genomes … Show more

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Cited by 3 publications
(4 citation statements)
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“…Published by Frontiers Canadian Society for Pharmaceutical Sciences leading to increased luminal bioavailability of oxygen and nitrate. This alteration in turn amplifies respiration-dependent choline catabolism by E. Coli, thereby enhancing host circulating TMAO levels [74]. This study emphasizes the significance of colonocyte dysfunction induced by a HFD.…”
Section: Journal Of Pharmacy and Pharmaceutical Sciencesmentioning
confidence: 63%
“…Published by Frontiers Canadian Society for Pharmaceutical Sciences leading to increased luminal bioavailability of oxygen and nitrate. This alteration in turn amplifies respiration-dependent choline catabolism by E. Coli, thereby enhancing host circulating TMAO levels [74]. This study emphasizes the significance of colonocyte dysfunction induced by a HFD.…”
Section: Journal Of Pharmacy and Pharmaceutical Sciencesmentioning
confidence: 63%
“…As reported, tryptophan deficiency could contribute to the development of IBD or aggravate disease activity. , It is not a coincidence that the concentration of tryptophan, the upstream substrate of serotonin, was observed significantly decreased in UC mice. In addition, the presence of specific intestinal microbiota members in intestinal inflammation may increase the abundance of some AAs, such as pathogenic Enterobacteriaceae and aspartate . On the other hand, intestinal bacteria might be able to generate D-AAs from L-AAs and peptidoglycans containing D-AA using a racemase mixture of AAs .…”
Section: Resultsmentioning
confidence: 99%
“…In addition, the presence of specific intestinal microbiota members in intestinal inflammation may increase the abundance of some AAs, such as pathogenic Enterobacteriaceae and aspartate. 33 On the other hand, intestinal bacteria might be able to generate D-AAs from L-AAs and peptidoglycans containing D-AA using a racemase mixture of AAs. 34 Although the concentrations of D-glutamine, D-lysine, and D-methionine significantly increased in UC mice, the physiological relevance between D-AAs and UC is still unclear.…”
Section: ■ Results and Discussionmentioning
confidence: 99%
“…Propionate, an abundant SCFA commonly derived from Bacteroides spp., can mediate colonization resistance against Salmonella enterica serovar Typhimurium ( S. Tm ) ( Shelton et al., 2022 ). However, in the inflamed gut, both S. Tm and E. coli use nitrate and nitrate-dependent propionate metabolism for intestinal expansion ( Winter et al., 2013 ; Shelton et al., 2022 ) Furthermore, S. Tm and pathogenic E. coli utilize aspartate ammonia-lyase ( aspA ) - dependent fumarate respiration for growth in the murine gut during colitis ( Yoo et al., 2022 ). Numerous instances of microbial functional synergy have been described in the inflamed gut ( Hughes et al., 2017 ; Spiga et al., 2017 ; Gillis et al., 2018 ; Zhu et al., 2020 ), and it will be important to understand their contribution to disease in human IBD patients.…”
Section: Interbacterial Community Functionsmentioning
confidence: 99%