Microbiota effects on cancer: from risks to therapies

Rea, Domenica; Coppola, Giovanni; Palma, Giuseppe; Barbieri, Antônio; Luciano, Antonio; Prete, Paola Del; Rossetti, Sabrina; Berretta, Massimiliano; Facchini, Giancarlo; Perdonà, Sisto; Turco, Maria Caterina; Arra, Claudio

doi:10.18632/oncotarget.24681

Cited by 172 publications

(153 citation statements)

References 82 publications

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“…These metabolites are produced through estrogen metabolism by several bacteria included in Clostridia and Ruminococcaceae families [25]. In addition, others estrogen-like metabolites can be also produced by oxidative and reductive reactions in the gut and by an induced synthesis of estrogen-inducible growth factors, which might have a carcinogenic potential.…”

Section: Is There a Link Between Gut Microbiota And Breast Cancer?mentioning

confidence: 99%

Breast Cancer and Its Relationship with the Microbiota

Fernández

Reina-Pérez

Astorga

et al. 2018

IJERPH

264

197

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The microorganisms that live symbiotically in human beings are increasingly recognized as important players in health and disease. The largest collection of these microorganisms is found in the gastrointestinal tract. Microbial composition reflects both genetic and lifestyle variables of the host. This microbiota is in a dynamic balance with the host, exerting local and distant effects. Microbial perturbation (dysbiosis) could contribute to the risk of developing health problems. Various bacterial genes capable of producing estrogen-metabolizing enzymes have been identified. Accordingly, gut microbiota is capable of modulating estrogen serum levels. Conversely, estrogen-like compounds may promote the proliferation of certain species of bacteria. Therefore, a crosstalk between microbiota and both endogenous hormones and estrogen-like compounds might synergize to provide protection from disease but also to increase the risk of developing hormone-related diseases. Recent research suggests that the microbiota of women with breast cancer differs from that of healthy women, indicating that certain bacteria may be associated with cancer development and with different responses to therapy. In this review, we discuss recent knowledge about the microbiome and breast cancer, identifying specific characteristics of the human microbiome that may serve to develop novel approaches for risk assessment, prevention and treatment for this disease.

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Section: Is There a Link Between Gut Microbiota And Breast Cancer?mentioning

confidence: 99%

Breast Cancer and Its Relationship with the Microbiota

Fernández

Reina-Pérez

Astorga

et al. 2018

IJERPH

264

197

View full text Add to dashboard Cite

show abstract

“…yoghurt, buttermilk, kefir) which have been shown to confer health benefits beyond their nutritional qualities (Table 1, 2, Figure 1). The efficacy of some probiotics against diarrhoea has been reported [33], as well as providing intestinal microbial balance [34], reduces the risk of colon and breast cancer [35], reduces blood pressure [17,[22][23][24]36], reduces lipid profiles [37], reduces allergies and food intolerances [38], inhibits the growth of pathogenic bacteria and is immunomodulatory [12,[39][40][41][42] (Figure 1). More recently, dysbiosis has been implicated to be involved in the pathogenesis of a number of disorders such as, Sjogren's syndrome [43], Parkinson's disease [44] and multiple sclerosis [45].…”

Section: Health Benefits Of Fermented Milk Productsmentioning

confidence: 99%

Anti-hypertensive peptides released from milk proteins by probiotics

2018

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The development of agricultural products as well as the industrialization of food production have led to dramatic lifestyle changes, particularly in dietary patterns, which in turn has increased the occurrence of chronic diseases and hypertension. In order to help overcome this, the food industry has developed functional milk products. Milk products, particularly fermented milk containing probiotics, are popular. Probiotics may promote gut health, reduce allergenicity, increase the bio-accessibility of fats/proteins in foods, and lower blood pressure because they contain poly-amines and bioactive peptides. Bioactive peptides have been shown to lower the risk of hypertension and cancer. Herein, we discuss the potential role of fermented milk as a functional drink acting against hypertension. However, longer-term research studies are necessary to evaluate the role of fermented milk drinks in supporting human health.

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“…2) [3,30]. In inflammation, DCs produce pro-inflammatory cytokines such as Il-6, Il-12, and Il-23 that lead to the reduction of Il-10 and increase inflammatory cytokines like TNF α, INF γ, and Il-17 [32].…”

Section: Role Of the Microbiota In Immunitymentioning

confidence: 99%

“…Lifestyle, diet, aging, and intake of antibiotics change the gut microbiota, which alters intestinal homeostasis and leads to many diseases, such as rheumatism, diabetes type II, obesity, and autoimmune diseases [32].…”

Section: Role Of the Microbiota In Immunitymentioning

confidence: 99%

Interaction of the microbiota with the human body in health and diseases

Altveş

Yıldız

Vural

2020

Bioscience of Microbiota, Food and Health

312

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The human body contains many microorganisms, including a large number of bacteria, viruses, fungi, and protozoa, which are referred to as the microbiota. Compared with the number of cells comprising the human body, that of the microbiota has been found to be much larger. The microbiome is defined as microorganisms and their genomes have been shown to contain about 100 times more genes than the human genome. The microbiota affects many vital functions in the human body. It contributes to regulation of the immune system, digestion of food, production of vitamins such as B12 and K, metabolization of xenobiotic materials, and many other tasks. Many factors affect the microbiota biodiversity, such as diet, medicines including antibiotics, relationships with the environment, pregnancy, and age. Studies have shown that the lack of microbiota diversity leads to many diseases like autoimmune diseases such as diabetes type I, rheumatism, muscular dystrophy, problems in blood coagulation due to lack of vitamin K, and disturbances in the transfer of nerve cells due to lack of vitamin B12, in addition to its involvement in a number of conditions such as cancer, memory disorders, depression, stress, autism, and Alzheimer's disease. The aim of this review is to summarize the latest studies discussing the relationship between the microbiota and the human body in health and diseases.

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Microbiota effects on cancer: from risks to therapies

Cited by 172 publications

References 82 publications

Breast Cancer and Its Relationship with the Microbiota

Breast Cancer and Its Relationship with the Microbiota

Anti-hypertensive peptides released from milk proteins by probiotics

Interaction of the microbiota with the human body in health and diseases

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