Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Bhattarai, Yogesh

doi:10.1111/nmo.13366

Cited by 50 publications

(34 citation statements)

References 43 publications

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“…These junctions are composed of transmembrane proteins such as claudins and occludins connected to the actin cytoskeleton via high molecular weight proteins called zona occludens (46). These structures are under the influence of the GM and its metabolites, which play a vital role in reciprocal gut-brain communication (47). All of the elements of the gut-brain axis described above may be individually affected by PD pathology to various degrees.…”

Section: Gut-brain Axis In Pdmentioning

confidence: 99%

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

et al. 2019

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It is well-recognized that the gut microbiota (GM) is crucial for gut function, metabolism, and energy cycles. The GM also has effects on neurological outcomes via many mechanisms, such as metabolite production and the gut-brain axis. Emerging evidence has gradually indicated that GM dysbiosis plays a role in several neurological diseases, such as Parkinson's disease (PD), Alzheimer's disease, depression, and multiple sclerosis. Several studies have observed that PD patients generally suffer from gastrointestinal disorders and GM dysbiosis prior to displaying motor symptoms, but the specific link between the GM and PD is not clearly understood. In this review, we aim to summarize what is known regarding the correlation between the GM and PD pathologies, including direct, and indirect evidence.

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Section: Gut-brain Axis In Pdmentioning

confidence: 99%

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

et al. 2019

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“…Supplementation of probiotics, prebiotics, synbiotics, and transplantation of fecal microbes may reduce the entry of harmful metabolites into the systemic circulation, contributing to the integrity of the gut and BBB. 165 Lactobacillus plantarum MTCC 9510 supplementation improved the intestinal and BBB integrity and reduced the abundance of Enterobacteriaceae. 166 Patients receiving probiotic treatment exhibited reduced serum C-reactive protein levels, improved insulin metabolism, and increased in Mini-Mental State Examination (MMSE) scores.…”

Section: Potential Therapeutic Tools For Promotion and Restoration Ofmentioning

confidence: 96%

<p>The Impact of Gut Microbiota Disorders on the Blood–Brain Barrier</p>

Wei¹,

Zhu²,

Feng³

et al. 2020

IDR

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The gut microbiota is symbiotic with the human host and has been extensively studied in recent years resulting in increasing awareness of the effects of the gut microbiota on human health. In this review, we summarize the current evidence for the effects of gut microbes on the integrity of the cerebral blood-brain barrier (BBB), focusing on the pathogenic impact of gut microbiota disorders. Based on our description and summarization of the effects of the gut microbiota and its metabolites on the nervous, endocrine, and immune systems and related signaling pathways and the resulting destruction of the BBB, we suggest that regulating and supplementing the intestinal microbiota as well as targeting immune cells and inflammatory mediators are required to protect the BBB.

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“…Epidemiological studies and animal experiments have established that gut microbiota impacts mammalian brain development and emotional behavior . Furthermore, bidirectional communication between the brain and the gut has long been recognized, and is known as the gut‐brain axis (GBA) . The vagus nerve may be an important pathway of communication between the microbiota in the gut and the brain .…”

Section: Introductionmentioning

confidence: 99%

The relationship between Helicobacter pylori infection and depressive symptoms in the general population in China: The TCLSIH cohort study

Zheng

Kumari

et al. 2019

Helicobacter

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Background: Depressive symptoms are a common, debilitating, and costly public health issue. Helicobacter pylori (H pylori) infection cause changes in the normal physiological state of the gastrointestinal (GI) flora. Although the physiological state of the GI tract is closely related to mental disorders, few population studies have examined the relationship between H pylori infection and depressive symptoms in the general population. The aim of this study was to examine whether H pylori infection is related to depressive symptoms among the general adult population. Materials and Methods: This cross-sectional study included 5558 inhabitants of Tianjin, China. H pylori infection was diagnosed with the carbon 13 breath test.Depressive symptoms were assessed using the Chinese version of 20-item Self-rating Depression Scale (SDS) with three cutoffs (45, 48, and 50) to indicate elevated depressive symptoms. Multiple logistic regression analysis were conducted to assess the association between H pylori infection and depressive symptoms. Results:The prevalence of depressive symptoms (SDS ≥ 45) was 12.7% in men and 17.4% in women. In multivariable models, the odds ratios and 95% confidence interval of having depressive symptoms by H pylori infection were 1.25 (1.01-1.56), 1.46(1.11-1.91), and 1.46 (1.05-2.06) for three cutoffs: 45, 48, and 50 in women. However, no significant difference was found between H pylori infection and depressive symptoms in men. Conclusions:This study firstly suggested that H pylori infection was related to depressive symptoms in women in the general adult population. Further prospective studies or randomized trials are required to clarify the causality. K E Y W O R D Scross-sectional study, depressive symptoms, Helicobacter pylori

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Microbiota‐gut‐brain axis: Interaction of gut microbes and their metabolites with host epithelial barriers

Cited by 50 publications

References 43 publications

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

The Role of the Gut Microbiota in the Pathogenesis of Parkinson's Disease

<p>The Impact of Gut Microbiota Disorders on the Blood–Brain Barrier</p>

The relationship between Helicobacter pylori infection and depressive symptoms in the general population in China: The TCLSIH cohort study

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